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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Intensity-adjustable pain management with prolonged duration based on phase-transitional nanoparticles-assisted ultrasound imaging-guided nerve blockade

Fig. 6

A Mechanical threshold before and after different treatments (The data were shown as mean ± SD, n = 5, #p < 0.05, ###p < 0.001 was compared with Turkey’s multiple analysis between PBS and levobupivacaine, ***p < 0.001 was compared between RLBP and levobupivacaine). B Mechanical threshold before and after different treatments. The black arrows in the figure mean ultrasound irradiation. (The data were shown as mean ± SD, n = 5, #p < 0.05, ###p < 0.001 was compared with Turkey’s multiple analysis between LBP + US and RLBP + US, *p < 0.05, **p < 0.01, ***p < 0.001 was compared with Turkey’s multiple analysis between RLBP and RLBP + US). C Mechanical threshold of mice treated by RLP, PBS, and PBS + US. The black arrows in the figure mean ultrasound irradiation. D Thermal latency before and after different treatments (The data were shown as mean ± SD, n = 5, #p < 0.05, ###p < 0.001 was compared with Turkey’s multiple analysis between PBS and levobupivacaine, ***p < 0.001 was compared with Turkey’s multiple analysis between the RLBP and the levobupivacaine group). E Thermal latency before and after different treatments. The black arrows in the figure mean ultrasound irradiation. (The data compared with Turkey’s multiple analysis were shown as mean ± SD, n = 5, ##p < 0.01, ###p < 0.001 between LBP + US and RLBP + US, *p < 0.05, ***p < 0.001 was compared with Turkey’s multiple analysis between RLBP and RLBP + US). F Thermal latency of mice treated by the RLP, PBS, and PBS + US. The black arrows in the figure mean ultrasound irradiation. G Immunofluorescence assay of ipsilateral L5 DRG at 54 h after treatment with the RLBP + US, LBP + US, and levobupivacaine + US. The scale bars are 50 μm

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