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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: Polymeric nanomedicines for the treatment of hepatic diseases

Fig. 9

(Reprinted with permission from Ref. [200], Copyright 2019, American Chemical Society)

Proposed elimination mechanism of biodegradable nanoparticle (NP) in the liver. Intravenously injected NPs enter the liver and into hepatic sinusoids. A Kupfer cells (KCs) take up the majority of circulating NPs on the basis of NP size. B NPs can escape from KCs. C, D NPs that are smaller than the diameter of liver sinusoidal fenestrations (up to 100–200 nm) can enter the space of Disse through LSECs or fenestrations. E NPs then collect in the space of Disse, where hepatocytes slowly internalize and process them for transport into the bile canaliculus. F Larger NPs may not be able to enter fenestrations or access by LSECs and thus continue to circulate throughout the body.

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