From: Polymeric nanomedicines for the treatment of hepatic diseases
Live cell type | Â | Functions | Related diseases |
---|---|---|---|
Parenchymal cells | Hepatocytes | Lipid, protein, and carbohydrate metabolism Detoxification Immune/inflammatory response Secretion of lipoproteins, coagulation factor, growth factors, and cytokines Ammonia and urea biosynthesis Synthesis of cholesterol, bile salts and phospholipids Start of bile formation and secretion | Viral hepatitis Alcohol-induced steatohepatitis (ASH) Non-alcohol steatohepatitis HCC Autoimmune diseases Wilson’s disease Hemochromatosis α1 antitrypsin deficiency |
Non-parenchymal cells | LESCs | Physical barrier and host defense Scavenger function Immune/inflammatory responses Secretion of cytokines Remove foreign materials and macromolecular waste | Hepatic veno-occlusive disease |
KCs | Host defense Immune/inflammatory response Detoxification Secretion of cytokines, chemokines, growth factors, and proteolytic enzymes Maintaining functional iron metabolism and bilirubin metabolism Control cholesterol metabolism | HBV or HCV Acute liver failure Chronic liver injury Metabolic and alcoholic liver disease NASH HCC Cholestatic liver diseases Liver fibrosis | |
HSCs | Vitamin A and lipid metabolism Detoxification Immune/inflammatory responses Secretion of lipoproteins, growth factors, and cytokines | Liver fibrosis and cirrhosis ASH, NASH, HCC |