Fig. 3

Cellular nanomechanics induced by cytoskeletal structures of micropatterned cells. a Fluorescent images of nucleus (blue) and actin bundles (green). Scale bar: 50 μm. b Illustration of cytoskeleton to affect cellular mechanics. Biophysical signals are induced into cells by mechanosensors on cell membrane to affect cytoskeletal assembly. The reorganization of actin bundles will regulate cell mechanics by the contractility. c Curves of indentation force and indentation distance measured by AFM. d Young’s modulus of micropatterned MG63 cells. The data present the mean ± SD, n = 10, N.S. present no significance, *p < 0.05, **p < 0.01