Fig. 4

The amilorative effects of CDDP Curcumin nanoparticles in renal cells. By increasing the expression of OCT2, Curcumin NPs can mitigate the nephrotoxic effects of cisplatin. Furthermore, Curcumin reduces inflammation by decreasing concentration of NO and TNF-α. It also decreases oxidative stress By overexpressing HO-1, GST, NQO1, serving as a ROS scavengers, and GSH. It improves mitochondrial function by rising Na + /K + -ATPase activity. Cisplatin-diamminedichloroplatinum (CDDP); Organic cation transporters 2 (OCT2); Nitric oxide (NO); Tumor necrosis factor α (TNF-α); Hemeoxygenase-1 (HO-1); glutathione S-transferases (GST); NAD(P)Quinine oxidoreductase1 (NQO1); Glutathione (GSH)