Fig. 4

A In vivo fluorescence imaging of different groups using C57BL/6 mice bearing TC-1 tumors at various times. B Schematic illustration of TC-1 tumor model and the administration schedule. C Change curves of body weights of different groups within investigated days. D Change curves of tumor volume versus time. E, F Dissociated tumor image after 22 days (the dotted circles indicated the cured tumors) and excised tumor weights. G H&E and TUNEL staining of tumor tissues in various groups after light irradiation. Scale bars: 50 µm. All tumors were irradiated once using a laser light at 660 nm with a light dose of 120 J cm⁻² (light power: 200 mW cm⁻²). Data are expressed as means ± s.d. (n = 5). *p < 0.05, **p < 0.01, ****p < 0.0001. (“ + ” and “−” denote with and without irradiation, respectively)