Fig. 7

A Representative immunofluorescence images and quantitative analysis of aorta root sections co-stained by phosphorylated SHP-1 antibody and Mac-3 antibody to assess the lesional SHP-1 activity (scale bar: 200 μm, ***P < 0.001); B Representative immunofluorescence images and quantitative analysis of aorta root sections co-stained with cleaved caspase-3 and Mac-3 to study the efferocytosis of apoptotic cells by macrophages. The in vivo phagocytic index was determined by manually counting the number of free apoptotic cells versus macrophages (scale bar: 100 μm, **P < 0.01, ***P < 0.001)