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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury

Fig. 2

Knokout of Treg cell leads to widespread microglia pyroptosis and impairs functional recovery after SCI. A Representative immunofluorescence images for GSDMD(pyroptosis) and IBA1(microglia) expression in Foxp3DTR + PBS and Foxp3DTR + DT mice at Day 7 postinjury; B Quantification of fluorescence intensity at Day 7 postinjury(n = 3); C Representative immunoblots exhibiting levels of pyroptosis-related protein in injured spinal cord at days 7 postinjury in Foxp3DTR + PBS and Foxp3DTR + DT mice; D Quantification of relative levels of pyroptosis-related protein (n = 3); E BMS scores during 28 days of recovery after SCI demonstrate impaired functional recovery in Foxp3DTR + DT mice (n = 6); F Footprint analysis at Day 28 postinjury demonstrate impaired functional recovery in foxp3DTR + DT mice; G The footprints quantifcation of mice walking 28 days after SCI(n = 6); H Swimming test at Day 28 postinjury demonstrate impaired functional recovery in foxp3DTR + DT mice; I Louisville Swim Scale in Foxp3DTR + PBS and Foxp3DTR + DT mice at Day 28 postinjury(n = 6); J MEP analysis was used as electrophysiological assessment in Foxp3DTR + PBS and Foxp3DTR + DT mice at Day 28 postinjury; K Quantification of peak-to-peak MEP amplitudes and latencies in Foxp3DTR + PBS and Foxp3DTR + DT mice (n = 6)

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