Fig. 4
Mechanism study of CNPs in suppresses kidney calcium oxalate crystal depositions. A 34 oxidative stress and 39 oxidative damage-related genes from the GSEA database. B, C The heatmap indicates that the expression of genes related to oxidative stress and oxidative damage; D, E Volcano plot analysis between different groups. The volcano plot was constructed using the fold change values and P-adjust. Red dots indicate upregulated genes; blue dots indicate downregulated genes. F Venn diagram analyzed of the CeO2-related differential gene expression between different groups. (Left Venn diagram: the left pale indicated number of up-regulated genes in the oxolate group versus the control group, and the right pale indicated number of down-regulated genes in the CNP intervention group versus the oxolate group; Right Venn diagram: the left pale indicated number of down-regulated genes in the oxolate group versus the control group, and the right pale indicated number of up-regulated genes in the CNP intervention group versus the oxolate group, and overlapped to obtain the intersection.)