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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Gold nanoparticle delivery to solid tumors: a multiparametric study on particle size and the tumor microenvironment

Fig. 4

Evaluation of tumor-specific parameters across the different groups. Violin plots of the respective indicated parameter for every group of animals (n > 16 per NP size). a The tumor volume, expressed in mm3 and measured by caliper measurements immediately prior to tumor resection. b The area of necrotic tissue in the tumor as determined by H&E staining relative to the area of the entire tissue slice. c The area positive for ECM in the tumor as determined by Picrosirius Red staining relative to the area of the entire tissue slice. d–h Relative level of d) TAMs, e) CAFs, f) TECs, g) TILs and h) cancer cells (CC) expressed relative to the total number of cells as determined by ImageStreamX Mark II analysis. i, j Relative level of i tumor perfusion and j tumor vessel permeability determined by AF555-BSA mediated optical imaging and expressed relative to the perfusion and permeability of the skull in the same mice. k–m The relative level (%) of k) tumor area occupied by CD31+ endothelial cells, l) CD31+ blood vessels covered by laminin, m) CD31+ blood vessels covered by NG2

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