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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Extracellular vesicles from IFN-γ-primed mesenchymal stem cells repress atopic dermatitis in mice

Fig. 5

Reduction of pruritus by IFN-γ-iMSC-EVs in AD mice. AD mice were subcutaneously administered with PBS or IFN-γ-iMSC-EVs (50 or 500 μg) for the negative control and test groups, respectively. A Analysis of transepidermal water loss (TEWL) levels. n = 5. Data are presented as mean ± SE. *p < 0.05; **p < 0.01. B The effect of IFN-γ-iMSC-EVs on itching number in AD mice. n = 5. Data are presented as mean ± SE. *p < 0.05. C Immunoblotting of IL-31Rα and OSMRβ in the skin tissue of AD mice that received IFN-γ-iMSC-EVs. n = 5. Data are presented as mean ± SE. *p < 0.05; #P < 0.05; ##p < 0.01. D Immunoblot analysis of phosphorylated STAT1 and STAT5 expression in skin tissues of AD mice that received IFN-γ-iMSC-EVs. Densities of phosphorylated STAT1 and STAT5 were normalized to those of total STAT1 and STAT5, respectively. n = 5. Data are presented as mean ± SE. *p < 0.05; #P < 0.05; ##p < 0.01

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