Fig. 5
From: Splenic-targeting biomimetic nanovaccine for elevating protective immunity against virus infection
CMR-PLGA/p54 NVs-elicited DCs maturation in vivo. A Schematic illustration showing the immunization protocol. B, C Statistic analysis of activated splenic DCs at different time points. D, E Flow cytometry analysis of activated splenic DCs collected on day 49. The DCs were collected from mice treated as described in (A). F–H The secretion level of TNF-α, IL-12 and IFN-γ from activated splenic DCs after various immunization. (I: PBS; II: free p54; III: p54 + FA; IV: PLGA/p54 NVs; V: MR-PLGA/p54 NVs; VI: CMR-PLGA/p54 NVs)