Fig. 4
From: Morphologic design of nanostructures for enhanced antimicrobial activity
Synthetic schemes. a Synthesis of N3-PDGC-b-PLLA, by sequential ring-opening polymerizations of glucose-carbonate and l-lactide monomers from an azido-containing initiator, followed by post-polymerization modification via thiol-yne reaction with cysteine to prepare the zwitterionic N3-PDGC(cys)-b-PLLA, and chain-end modification of N3-PDGC(cys)-b-PLLA with dibenzocylcooctyne (DBCO)-functionalized fluorescent MBâ„¢ 488 to afford fluorescently-labeled PDGC(cys)-b-PLLA. b AgOAc loading into polymer nanostructures, through interactions with di-thioether and carboxylate groups, and release. Reprinted with permission from ref. [52]. Copyright (2022) American Chemical Society