Table 2 Information of animal experiment
Study | Sample size (T-C) | Species | Gender | Age | Body weight | Model | Model size | Evaluation method | Follow up time |
|---|---|---|---|---|---|---|---|---|---|
Li et al. 2021 [35] | 3–3 | SD rats | Female | 8 weeks old | 220–250 g | Cranial bone defect | 6 mm | Micro-CT, histology, immunohistology | 6 and 15 weeks |
Xu et al. 2022 [36] | – | SD rats | Male | 10 weeks old | – | Cranial bone defect | 5 mm | Micro-CT, histology, immunohistology | 6 and 12 weeks |
Miao et al. 2022 [37] | 5–5 | SD rats | Female | 6 weeks old | – | Cranial bone defect | 5 mm | Micro-CT, histology, immunohistology | 4 and 8 weeks |
Li et al. 2022 [38] | – | SD rats | Female | 8 weeks old | 220–240 g | Cranial bone defect | 4 mm | Micro-CT, histology | 8 weeks |
Wang et al. 2018 [39] | 5–5 | Wistar rats | Female | – | 200 g | Femoral bone defects | 2.5 mm | Micro-CT, histology, immunohistology | 8 weeks |
Tong et al. 2019 [40] | 5–5 | SD rats | Female | 12 weeks old | 300–400 g | Tibia bone defect | 2.5 mm | Micro-CT, histology | 10 weeks |
Hu et al. 2022 [41] | 9–9 | SD rats | – | – | – | Femoral bone defects | 3 mm | Micro-CT, histology | 6 and 12 weeks |
Qing et al. 2022 [42] | – | SD rats | Male | 6–8 weeks old | – | Cranial bone defect | 5 mm | Micro-CT, histology, immunohistology | 4 and 10 weeks |
Wang et al. 2019a [43] | 4–4 | SD rats | – | 10 weeks old | 220–250 g | Cranial bone defect | 4.5 mm | Micro-CT, histology, immunohistology | 4 and 8 weeks |
Wang et al. 2020 [44] | 5–5 | SD rats | – | 10 weeks old | 300–350 g | Cranial bone defect | 5 mm | Micro-CT, histology | 8 and 12 weeks |
Wang et al. 2019b [45] | 3–3 | C57 mice | Female | 6 weeks old | 17–19 g | Cranial bone defect | 5 mm | Micro-CT, histology | 28 days |
Wu et al. 2021 [46] | 8–8 | SD rats | Male | 12 weeks old | – | Tibia bone defect | 2.5 mm | Micro-CT, histology | 5 and 10 weeks |
Yang et al. 2018 [47] | 8–8 | SD rats | Male | 12 weeks old | 300–350 g | Cranial bone defect | 5 mm | Micro-CT, histology | 4 and 6 weeks |
Liu et al. 2022 [48] | - | SD rats | – | – | – | Cranial bone defect | 5 mm | Micro-CT, histology, immunohistology | 4 weeks |
Miao et al. 2019 [49] | - | SD rats | – | – | – | Cranial bone defect | 5 mm | Micro-CT, histology | 3,6 and 9 weeks |
Chen et al. 2020 [50] | 4–4 | SD rats | Male | 12 weeks old | 320 g | Cranial bone defect | 5 mm | X-ray, Micro-CT, histology | 4 and 8 weeks |
Tan et al. 2022 [51] | - | SD rats | – | – | 250 g | Cranial bone defect | 3 mm | Micro-CT, histology, immunohistology | 8 weeks |
Wang et al. 2021 [52] | 4–4 | SD rats | Male | – | 190–240 g | Cranial bone defect | 6 mm | Micro-CT, histology, immunohistology | 2 and 6 weeks |