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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer

Fig. 3

Cell uptake and cytotoxicity. a CLSM images of BxPC3 cells after incubation with Cy5.5-labeled AuNCs, AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox for 4 and 12 h (scale bar: 20 μm). b ICP–MS analysis of the intracellular Au levels in BxPC3 cells after incubation with AuNCs, AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox for 4 and 12 h. c Viability of BxPC3 cells treated with Dox, AuNCs, AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox with or without NIR irradiation. d Live/dead staining images of BxPC3 cells after treatment with the different preparations. Live cells were stained with calcein-AM (green), and dead cells were stained with propidium iodide (red) (scale bar: 100 µm). e FCM analysis of the apoptosis levels of BxPC3 cells after incubation with different preparations with or without NIR irradiation

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