Fig. 6

In vivo intratumoral penetration, PTT and PDT efficiency and CT imaging. a CLSM images of tumor slices collected from mice receiving AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox. The blue, green and red signals were from the fluorescence of DAPI-stained nuclei, anti-CD31-stained blood vessels and Cy5.5-labeled preparations, respectively. b Quantitative analysis of the distance between the nanosamples and blood vessels. c Infrared thermal images of BxPC3 tumor-bearing mice intravenously administered different formulations followed by NIR irradiation and (d) temperature change curves of NIR-irradiated tumors. e In vivo CT imaging of BxPC3 tumor-bearing mice at 0 h, 2 h, 6 h, 12 h and 24 h after intravenous injection of iohexol, AuNCs/Dox, M@AuNCs/Dox and Col-M@AuNCs/Dox (red arrows indicate the tumor site). f Quantitative CT values of the tumors in BxPC3 tumor-bearing mice at different time points