Fig. 2
Biodistribution of MNPs with different coatings 7 days after the last dose administered to C57BL/6 mice. a, b Temperature dependence of the AC magnetic susceptibility: a in-phase and b out-of-phase components of murine tissues from mice treated with MNPs with the different coatings at 7 days post-administration. The height of the maximum of these signals is a surrogate indicator of the concentration of the particles in the tissues. The different organs are represented as continuous colored lines: spleen, purple; liver, black; lung, blue; and kidney, red. A single point was measured at room temperature for the brain, heart and thymus, as indicated in pink, green and orange, respectively. c The height of the out-of-phase magnetic susceptibility maximum at 300 K in spleen, liver, lung, kidney, brain, heart and thymus. Of the total number of mice used for each treatment group (n = 7), 4 mice per group were analyzed and the data obtained is shown as the mean ± SD (n = 4)