From: Biomimetic cell-derived nanocarriers in cancer research
Advantages of biomimetic cell-derived nanocarriers | Limitations of biomimetic cell-derived nanocarriers |
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Biological compatibility Stealth properties (reduce non-specific interactions) Tuneable physical, chemical and biological properties (different cell sources, inherent biological properties) Biointerfacing capabilities. Ability to retain cellular properties Improve accumulation and efficacy at the target site (like solid tumors) Immune escape (evading uptake or clearance by the reticuloendothelial system) Prolonged circulation time Protect the encapsulated cargo | Large scale-up (sterile conditions, reproducibility) Standardized protocols (for cell culture to specific cell type) and well-stablished characterization tools Safety concerns (immunogenicity and virulence) when they are derived from pathogens Long term storage Heterogeneity (methods to validate their structural integrity and functionality) Quality control (contamination: microorganisms, denatured proteins) |