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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: Tenofovir-tethered gold nanoparticles as a novel multifunctional long-acting anti-HIV therapy to overcome deficient drug delivery-: an in vivo proof of concept

Fig. 7

A Inhibitory effect of the free TNF, AuNPs, and AuNP-TNF on HIV-1 Reverse Transcriptase (RT-ase) activity. Data are expressed as mean±SD of IC50 (µg/mL). B Inhibitory effect of the free TNF, AuNPs, and AuNP-TNF on HIV-1 protease activity. Data are expressed as mean ± SD RFUs captured from GFP release in different groups, concentrations (µg/mL), and time points. Data is represented as three independent experiments. Statistical significance between the treated group of AuNP-TNF as compared to the free drug (TNF) in anti-HIV1 RT-as assay and with the anti-HIV1 protease enzyme control group (PC) in the is presented by an asterisk (***denotes p ≤ 0.0001)

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