Scheme 1
From: Acidic and hypoxic tumor microenvironment regulation by CaO2-loaded polydopamine nanoparticles
Schematic illustration of CaO2@mPDA-SH nanoparticles dually regulate acidic and hypoxic tumor microenvironments. A Preparation steps of CaO2@mPDA-SH nanoparticles. B CaO2@mPDA-SH nanoparticles accumulate in tumor sites via the EPR effect, CaO2 exposed in acidic microenvironment can consume acid with generating oxygen, thereby allowing for the achievement of tumor growth inhibition, immune activation and antitumor metastasis effect. C The relief of hypoxia can further reduce lactic acid production at the source by down-regulating the expression of HIF-1α, which further down-regulated the expression of glycolysis associated enzymes including GLUT1 and LDHA