Fig. 3
From: Engineering magnetic nano-manipulators for boosting cancer immunotherapy
a TEM image of DCs co-incubated with Hsp70–SPIONs; scale bar = 200 nm. b Tumor volume in different experimental groups. c Kaplan–Meier survival curves for one control and eight experimental groups. d Immunofluorescence staining of glioma cryosections for Ly6c+ (red) NK cells, CD45RO+ (red) and CD8+ (green) T cells; scale bar = 25 μm [69]. Copyright 2015, Elsevier. e Nano–Fe3O4-carrying tumor-derived antigenic microparticles (T-MPs) surface-decorated with CpG-loaded liposomes to yield an anticancer vaccine (Fe3O4/T-MP–CpG/Lipo). f Fe3O4/T-MP–CpG/Lipo induced the up-regulation of CD86, CD80, and CD40 on macrophages (upper) and bone marrow-derived DCs (lower). Statistical significance was calculated by one-way ANOVA with Bonferroni’s post-test; *P < 0.05, **P < 0.01, ***P < 0.001. g Analysis of CD3+CD4+ CD3+CD8+ T cells in the lymph nodes (upper) and spleen (lower) [70]. Copyright 2019, American Chemical Society