Fig. 6
From: Engineering magnetic nano-manipulators for boosting cancer immunotherapy
a Representative immunofluorescence staining for CD11b (red), CD206 (red), and CD80 (green) of MMTV-PyMT tumor sections obtained at 7 and 21 days; scale bars = 100 μm. b Co-cultures of cancer cells, macrophages, and ferumoxytol show signs of pro-inflammatory macrophage activation [95]. Copyright 2016, Springer Nature. c Mechanism of IONP-induced M1 activation. d Populations of M1 macrophages (labeled by F4/80+ and CD80+) in melanoma tumors treated with or without IONP@DSiO2 at day 12 after tumor implantation. All data are representative of at least three (n = 3) independent experiments for each experimental group and are displayed as mean ± SD; *P < 0.05 (Student’s t-test) [98]. Copyright 2019, American Chemical Society