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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Nanomedicine for renal cell carcinoma: imaging, treatment and beyond

Fig. 2

Targeted nanobubbles carrying CAIX polypeptides for targeted binding to a variety of malignant tumors were constructed, and targeted binding ability and ultrasound imaging effect in different types of tumors were evaluated. A The image of targeted nanobubbles under an optical microscope and transmission electron microscope. B Merged image confirms that biotin-streptavidin system successfully linked the polypeptides to the surfaces of targeted nanobubbles validated by dual-fluorescence. C Targeted nanobubbles could gather around CAIX-positive cells (786-O and Hela cells). Peak intensity and duration time of targeted nanobubbles and blank nanobubbles were different in CAIX-positive transplanted tumor tissues in vivo. Figure adapted from Lianhua Zhu et al. [68]

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