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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Ultrasound targeted microbubble destruction-triggered nitric oxide release via nanoscale ultrasound contrast agent for sensitizing chemoimmunotherapy

Fig. 8

Hypoxia relief and immune response. A Immunofluorescence images of CRT of tumor sections in various treatments. CRT marked with DyLight 488-labeled IgG exhibited green fluorescence, and the nuclei labeled with DAPI staining solution exhibited blue fluorescence. Scale bar: 100 μm. B HIF-1α expression on tumors of different groups. HIF-1α showed red fluorescence, and the nuclei labeled with DAPI showed blue fluorescence. Scale bar: 100 μm. C, D FCM and percentages of CD8 + T cells (gated CD3 +) in tumors. E IFN-γ expression level assessed by ELISA. F TNF-α expression level detected by ELISA. Data are presented as mean ± SD (n = 3, *p < 0.05, **p < 0.01)

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