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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Facile synthesis of multi-faceted, biomimetic and cross-protective nanoparticle-based vaccines for drug-resistant Shigella: a flexible platform technology

Fig. 6

Immunogenicity of nanovaccines. a Schedule of immunization. b Immunoblot against S. dysenteriae 1 (Sd1) and S. flexneri 2a (Sf2a) using 28th day sera of nanovaccine immunized mice. c Serum IgG and d IgA antibody titer assessed by ELISA (n = 3, mean ± S.D.) (two-way ANOVA, Tukey’s multiple comparisons test, ****p < 0.0001 indicate statistically significant difference with respect to control, x-axis represents days of blood collection). e Level of IL-6, IL-10 and IFN-γ cytokines in sera of immunized mice at 35th day of primary immunization quantified using cytokine ELISA (normalized with control) (one-way ANOVA, Tukey’s Multiple comparisons test; for IL-6 ***p < 0.001 and ****p < 0.0001 indicate statistically significant difference between the respective groups; for IL-10, **p < 0.01 and ***p = 0.0004 indicate statistically significant difference between the respective groups; for IFN-ɣ, *p < 0.05, **p < 0.01 and ***p = 0.0001 indicate statistically significant difference between the respective groups; ns indicates non-significance)

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