Fig. 4
hADMSCs-Exo could alleviate CCl4-induced mice liver fibrosis in vivo A Diagram of experimental scheme. B Elastograms obtained using shear wave elastrography (reliable images were obtained when uniform colour filled > 90% of the sampling area) and liver stiffness quantification. C Body weight changes during treatment. D Representative photographs of lives from mice in each group and histopathological images of liver sections were evaluated using H&E, Masson trichrome staining and Sirius red staining in animals with CCl4-induced cirrhosis. Liver histopathology grading was evaluated by necro-inflammatory scoring and Ishak (modified Knodell) scoring system after treatment. E Images of immunohistochemistry staining of extracellular matrix (ECM) proteins (collagen I and α-SMA). F The protein levels of ECM and EMT-related proteins in the liver tissues of the mice with different treatments. SWE, shear wave elastrography. LFG, liver fibrosis group, REG, regression group. Data are expressed as mean ± SEM (n = 6), ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001