Fig. 5

hADMSCs-Exo treatment improves liver function and regeneration, reduces liver inflammation and apoptosis. A The Hyp and MDA levels of normal mice (Sham), fbrotic mouse model and the mice injected with PBS, hADMSCs or hADMSCs-Exo were measured with corresponding test kit B Serum levels of AST, ALT, ALP in different groups. C The relative inflammatory gene expression for IL-1β, IL-6, IL-10 and TNF-α. D Immunohistochemical staining was performed to detect the protein expressions of Ki67, HNF-4α and caspase 3 in the injured liver of mice treated with hADMSCs and hADMSCs-Exo. Scale bar, 40 μm. AST, aspartate aminotransferase, ALT, alanine aminotransferase, ALP, alkaline phosphatease. LFG, liver fibrosis group, REG, regression group. Data are expressed as mean ± SEM (n = 4), ns, not significant, *p < 0.05, **p < 0.01 and ***p < 0.001