Fig. 7

hADMSCs-Exo inhibits liver fibrosis by regulating choline metabolism. A Score plots from the PCA model derived from the UPLC-MS profile of liver obtained from mice in different groups. B Score plots from the OPLS-DA model from metabolic profiles of different groups. C Venn diagram of differential metabolites between LFG, REG, hADMSCs and hADMSCs-Exo-treated group. D The hierarchical clustering heatmap of the top 30 metabolites between different groups. E Summary of pathway analysis of differential metabolites between REG and hADMSCs-Exo-treated group. F Summary of pathway analysis of differential metabolites between LFG and hADMSCs-Exo-treated group. G The quantitative analysis of the key metabolites in choline metabolism based on metabolic profiles. H Quantitative analyses of the key metabolites in choline metabolism by ELISA. LFG, liver fibrosis group, REG, regression group. Data expressed as the mean ± SEM. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001