Fig. 5
Different Imaging patterns of [68Ga]Ga-MSA nanoparticle in MC38-Luc tumor-bearing mouse model after anti-PD1 treatment. MC38-Luc tumor-bearing mice were treated with 100 μg of anti-PD1 (black filled inverted triangle) on day 7, day 10, and day 13. Experiments were conducted 15 d after initiating the anti-PD1 treatment. a MC38-Luc tumor volumes in mice treated with anti-PD1 (non-responders, n = 5; responders, n = 4). b Flow cytometry for the frequency of CD206+ cells in non-responder and responder tumors (non-responders, n = 5; responders, n = 4). c Overview of experimental representative PET images of MC38-Luc tumor-bearing mice that responded or failed to respond to anti-PD1 treatment. d Measurement of LBP ratio at day 22 in the anti-PD1 treated tumor (non-responders, n = 5; responders, n = 4). Similar results were obtained from two independent experiments. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001