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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Apoptotic tumor cell-derived microparticles loading Napabucasin inhibit CSCs and synergistic immune therapy

Fig. 8

In vivo validation of the mechanism of NAP inhibiting colon cancer. A The KEGG enrichment analysis indicated that the immune-related pathway was regulated after TMPs treatment. B GSEA algorithm was used to analyze the changes in the cytosolic DNA-sensing pathway after TMPs treatment. C p-TBK1(Ser172) and p-IRF3(Ser386), markers of activation of innate immune pathway cytosolic DNA-sensing, were detected after TMPs treatment. D–F RT-qPCR detected downstream target genes of the DNA-sensing pathway. G–H Representative flow analysis of CD3+CD4+ T cells and CD3+CD8+ T cells in tumor tissues. I–J Representative fluorescent images of CD3+CD4+ T cells and CD3+CD8+ T cells in tumor tissues. (n = 6, scale bars:100 μm)

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