Fig. 2
Detection of replicating infectious SARS-CoV-2 load in the respiratory tract of liposome-based SARS-CoV-2 RBD and N proteins or mRNA vaccinated and virus challenged ferrets. One-year-old male ferrets were vaccinated twice at 3 weeks interval intranasally with liposomes entrapped SARS-CoV-2 RBD (spike) and nucleocapsid (N) proteins or mRNA and monosodium urate crystal adjuvant and challenged with SARS-CoV-2 intranasally. The swab samples collected from: A, D Nostrils and B, E Oro-pharynx at day post challenge (DPC) 2, 4, 7, 9, 11, and 14; and samples of C, F nasal turbinates collected at DPC 7 were measured by cell culture method for the infectious viral load, expressed in log10 TCID50 per mL of swab fluid or per g tissue. Each bar is the mean of 3 to 6 animals ± SEM