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Fig. 9 | Journal of Nanobiotechnology

Fig. 9

From: Enhanced mucosal immune responses and reduced viral load in the respiratory tract of ferrets to intranasal lipid nanoparticle-based SARS-CoV-2 proteins and mRNA vaccines

Fig. 9

Detection of SARS-CoV-2 specific virus neutralization titers in the serum of vaccinated and virus challenged ferrets. One-year-old male ferrets were vaccinated twice at 3 weeks interval intranasally with liposomes entrapped either proteins or mRNA of SARS-CoV-2 S-RBD and N along with monosodium urate crystal adjuvant and challenged with SARS-CoV-2 intranasally. The serum samples collected at DPC 14 were analyzed for VN titers using a commercial kit and calculated the % viral inhibition values. A S-RBD + N proteins-based vaccinates; B S-RBD + N mRNA-based vaccinates. Each bar is the mean of 3 animals ± SEM. Statistical analysis was performed by using one way ANOVA with Tukey test

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