Fig. 8

Celecoxib-loaded PCL nano fibers were promoting CHSY3 expression. a CS concentration detected by DMMB analysis at week 6 and week 12. b–f PCR results of CHSY1 (b), CHSY2 (c), CHSY3 (d), CSGALNACT1 (e), and CSGALNACT 2 (f) in NP of rabbit IDD models treated with PCL, PCL/2% celecoxib, and PCL/6% celecoxib nano fibers for 6 weeks and 12 weeks. g, h IHC result of CHSY3 in NP of rabbit IDD models treated with PCL, PCL/2% celecoxib, and PCL/6% celecoxib nano fibers for 6 weeks and 12 weeks. *P < 0.05 compared with the puncture group, ^#P < 0.05 compared with the puncture + PCL group, and ^†P < 0.05 compared with the puncture + PCL/2% celecoxib group