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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Highly specific neutrophil-mediated delivery of albumin nanoparticles to ectopic lesion for endometriosis therapy

Fig. 4

Neutrophil-mediated Accumulation of Intraperitoneally Injected BSA-NPs in Ectopic Lesion. A, B. Imaging A and quantification B of FITC-BSA-NPs uptake by neutrophils in peritoneal fluid, ectopic endometrium, and ectopic lesions 16 h after intraperitoneal or intravenous injections. N = 3 per group. C Representative flow cytometry gating plots showing CD11b+ Ly6G+ neutrophils in the peritoneal lavage fluid, ectopic endometrium, and ectopic lesions of anti-Ly6G − or isotype control-treated mice. D Quantification of CD11b+ Ly6G + neutrophils in the peritoneal lavage fluid, ectopic endometrium, and ectopic lesions of anti-Ly6G − or isotype control-treated mice. N = 3 or 4 per group. E, F Ex vivo fluorescence images E and corresponding quantification of average fluorescence intensities of eutopic endometrium, ectopic lesions, and major organs F collected from anti-Ly6G − or isotype control-treated mice 16 h post intraperitoneal injection of FITC-BSA-NPs. N = 11 per group. G The ratio of ectopic/eutopic fluorescence in F. N = 11 per group. H Schematic diagram showing neutrophil-mediated accumulation of BSA-NPs in ectopic lesions. Data were shown as mean ± SEM and analyzed by two-tailed t-test. *P < 0.05, **P < 0.01

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