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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment

Fig. 4

Strategies for remodeling immune environment. A Remove immunosuppressive factors, such as PD-1 and CTLA-4, etc. B Inhibit function of immunosuppressive subpopulation, such as TAMs (M2 phenotype), MDSCs and Tregs. C Enhance antitumor immune in the form of inducing cancer cells immunogenic cell death (ICD), damage-associated molecular patterns (DAMPs) or antigen release; delivering adjuvants or cytokines, and co-stimulating activation of immune cell

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