Fig. 5
Strategies for reshaping the physicochemical microenvironment. A Ameliorate the hypoxia state of the TME in the methods of delivering O2 or catalyzing O2 production in situ of TME. B Relieve the low pH state of the TME by blocking the efflux of intracellular acid metabolites or promote intracellular acid metabolites generation to induce cancer cells acidosis. C Destruct redox homeostasis in the forms of increased ROS generation in the TME, existing GSH consumption and attenuated GSH generation