Fig. 6

Strategies for reshaping the biological microenvironment. A Remove tumor-derived sEVs from circulation to increased intestinal A-Exo, and attenuated A-Exo-induced tumor metastasis. B Regulate collagen degradation and decomposition to reshape the ECM. C Block or consume energy metabolism raw materials (such as glucose, lactate, glutamine, etc.) or silence gene of energy metabolism to induce cancer cell death