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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: In-Vivo fluorescent nanosensor implants based on hydrogel-encapsulation: investigating the inflammation and the foreign-body response

Fig. 5

Tissue response scores for the (a) implant site, (b) tissue surrounding the implant, (c) fibrosis, (d) edema, (e) neovascularization, and (f) total adverse tissue reaction. The inflammation at and surrounding the implant site, edema, and neovascularization were rated on a scale of 0 to 4: 0 is absent, 1 is minimal, 2 is mild, 3 is moderate, and 4 is severe. Fibrosis was rated on a scale of 1 to 3, with 1 being only a mild fibrous encirclement, 2 being moderate or poorly organized fibrous encirclement, and 3 being a well-organized and epithelioid histiocytic cap. The total adverse tissue reaction was obtained by summing all the components except fibrosis. (data presented as mean, n = 3 for formulation 3, and n = 2 for the other formulations)

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