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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy

Fig. 4

Pharmacokinetics and targeting capability of (Lipo + M)@E NPs. (A) Representative photographs of blood samples collected from C57BL/6 mice after administration of different nano-materials at various time points. (B) Pharmacokinetic curves of different nano-materials. n = 3. Fluorescence photos (C) and semi-quantitative (D) show the fluorescent signals of Ce6 in aortas from ApoE−/− mice. ApoE−/− mice fed with HFD for 2 months were intravenously injected with different NPs. After administration of 12 h, the aortas of ApoE−/−mice were isolated for detection. Data are means ± SD, n = 3, **P < 0.01 vs. the Lipo@Ce6 NPs. (E) Immunofluorescence imaging showing accumulation and infiltration of different nano materials (immunofluorescence stained for anti-PEG) in the aortic roots of ApoE−/− mice after 8 weeks of serial treatment. Blue indicated nuclei and purple indicated nano materials (stained for anti-PEG) in plaque. Scale bars = 200 μm. (F) Analysis of (Lipo + M)@E NPs fluorescence intensity (stained for anti-PEG) along the white arrowed lines. n = 3

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