Fig. 7

The biocompatibility evaluation of FZ/MER-AgMOF@Bm in vivo. (A) Schematic diagram of in vivo toxicity experimental design (n = 5). (B) Mice weight changes after injecting with normal saline, AgMOF (10 mg/kg), AgMOF@Bm (10 mg/kg), FPS-ZM1 (2 mg/kg), meropenem (2 mg/kg), FZ/MER-AgMOF (FPS-ZM1 dose of 2 mg/kg) or FZ/MER-AgMOF@Bm (FPS-ZM1 dose of 2 mg/kg) during 1 week. (C) Representative images of H&E staining for vital organs from mice at 1 week after intravenous injection of different reagents. Scale bar: 100 μm. (D) Complete blood count (CBC) for mice at 1 week after intravenous injection of different reagents. Data are derived from three independent experiments and presented as mean ± SEM in the bar graphs. ns: not significant