Skip to main content
Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Novel plant-derived exosome-like nanovesicles from Catharanthus roseus: preparation, characterization, and immunostimulatory effect via TNF-α/NF-κB/PU.1 axis

Fig. 6

CLDENs alleviated cyclophosphamide-induced immunosuppression. AD Effect of CLDENs on the number of white blood cells (A), lymphocytes (B), neutrophils (C), and monocytes (D) in the peripheral blood of immunosuppressed mice (n = 5). E, F Effect of CLDENs on the secretion levels of cytokines TNF-α (E) and IL-2 (F) in the serum of mice in a cyclophosphamide immunosuppression model (n = 3). G, H Effect of CLDENs on splenic lymphocyte subpopulations of immunosuppressed mice, number (G) and proportion (H). I Impact of CLDENs on the immunosuppressed mice's ability to remove carbon particles (n = 3) J Effects of CLDENs on cell cycle distribution of bone marrow cells in immunosuppressed mice (n = 3). K Effect of CLDENs on the relative body weight gain of cyclophosphamide-induced immunosuppressed mice (n = 10). L Effects of CLDENs on the liver and kidney tissues of cyclophosphamide-induced immunosuppression mice were analyzed by hematoxylin–eosin staining. Data were mean ± SD; *P < 0.05, **P < 0.01 and ***P < 0.001 vs. Blank; #P < 0.05, ##P < 0.01 and ###P < 0.001 vs. Model

Back to article page