Fig. 5From: Natural exosome-like nanoparticles derived from ancient medicinal insect Periplaneta americana L. as a novel diabetic wound healing acceleratorDiabetic mouse full-thickness skin wounds were treated with PA-ELNs. (A) Representative pictures of wounds in each group on days 0, 4, 8, 12 and 16. Wound closure rates of each group over 16 days (B, C). (D) Levels of IL-6 and TNF-α in wound biopsy at Day 16 by ELISA determination. *P<0.05 versus the DM(+) group. Representative images of wound biopsy at Day 16 by H&E staining (E) and Masson’s trichrome staining (F)Back to article page