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  1. Macrophage polarization and reprogramming in the lung play a critical role in the initiation, development and progression of acute lung injury (ALI). Regulating the activation and differentiation of pulmonary ...

    Authors: Lu Wang, Huasheng Zhang, Liya Sun, Wei Gao, Ye Xiong, Aying Ma, Xiali Liu, Lei Shen, Qiang Li and Hong Yang

    Citation: Journal of Nanobiotechnology 2020 18:38

    Content type: Research

    Published on:

  2. Functionalized multi-walled carbon nanotubes (MWCNT) have become the focus of increased research interest, particularly in their application as tools in different areas, such as the biomedical field. Despite t...

    Authors: Sara Nahle, Hilary Cassidy, Mélanie M. Leroux, Reuben Mercier, Jaafar Ghanbaja, Zahra Doumandji, David Matallanas, Bertrand H. Rihn, Olivier Joubert and Luc Ferrari

    Citation: Journal of Nanobiotechnology 2020 18:36

    Content type: Research

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  3. Novel methods are necessary to reduce morbidity and mortality of patients suffering from infections with Pseudomonas aeruginosa. Being the most common infectious species of the Pseudomonas genus, P. aeruginosa is...

    Authors: Leisha M. Armijo, Stephen J. Wawrzyniec, Michael Kopciuch, Yekaterina I. Brandt, Antonio C. Rivera, Nathan J. Withers, Nathaniel C. Cook, Dale L. Huber, Todd C. Monson, Hugh D. C. Smyth and Marek Osiński

    Citation: Journal of Nanobiotechnology 2020 18:35

    Content type: Research

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  4. The polymer-based drug/gene delivery is promising for the treatment of inherent or acquire disease, because of the polymer’s structural flexibility, larger capacity for therapeutic agent, low host immunogenici...

    Authors: Mingxing Wang, Bo Wu, Jason D. Tucker, Sapana N. Shah, Peijuan Lu and Qilong Lu

    Citation: Journal of Nanobiotechnology 2020 18:34

    Content type: Research

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  5. Prevalence of osteoporosis is rapidly growing and so searching for novel therapeutics. Yet, there is no drug on the market available to modulate osteoclasts and osteoblasts activity simultaneously. Thus in pre...

    Authors: K. Marycz, P. Sobierajska, M. Roecken, K. Kornicka-Garbowska, M. Kępska, R. Idczak, J.-M. Nedelec and R. J. Wiglusz

    Citation: Journal of Nanobiotechnology 2020 18:33

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2020 18:79

  6. Gold nanoparticles (GNPs) are one of the most widely used nanomaterials in various fields. Especially, the unique chemical and physical properties make them as the promising candidates in drug target identific...

    Authors: Xiao Tu, Xiaoping Tan, Xiaozhou Qi, Aiguo Huang, Fei Ling and Gaoxue Wang

    Citation: Journal of Nanobiotechnology 2020 18:32

    Content type: Research

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  7. Myeloid derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) are two of the major players involved in the inhibition of anti-tumor immune response in cancer patients, leading to poor progno...

    Authors: Laura Pinton, Sara Magri, Elena Masetto, Marina Vettore, Ilaria Schibuola, Vincenzo Ingangi, Ilaria Marigo, Kevin Matha, Jean-Pierre Benoit, Alessandro Della Puppa, Vincenzo Bronte, Giovanna Lollo and Susanna Mandruzzato

    Citation: Journal of Nanobiotechnology 2020 18:31

    Content type: Research

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  8. The surface of a nanoparticle adsorbs molecules from its surroundings with a specific affinity determined by the chemical and physical properties of the nanomaterial. When a nanoparticle is exposed to a biolog...

    Authors: Jasmina Kurepa, Timothy E. Shull and Jan A. Smalle

    Citation: Journal of Nanobiotechnology 2020 18:28

    Content type: Research

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  9. Neural interfaces often elicit inflammatory responses and neuronal loss in the surrounding tissue which adversely affect the function and longevity of the implanted device. Minocycline, an anti-inflammatory ph...

    Authors: Alexander Dontsios Holmkvist, Johan Agorelius, Matilde Forni, Ulf J. Nilsson, Cecilia Eriksson Linsmeier and Jens Schouenborg

    Citation: Journal of Nanobiotechnology 2020 18:27

    Content type: Research

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  10. Gene therapy remains a significant challenge due to lots of barriers limiting the genetic manipulation technologies. As for non-viral delivery vectors, they often suffer insufficient performance due to inadequ...

    Authors: Xi-Xi Ma, Jing-Liang Xu, Yi-Yang Jia, Ya-Xuan Zhang, Wei Wang, Chen Li, Wei He, Si-Yuan Zhou and Bang-Le Zhang

    Citation: Journal of Nanobiotechnology 2020 18:26

    Content type: Research

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  11. Oleic acid (OA) is reported to show anti-inflammatory activity toward activated neutrophils. It is also an important material in nanoparticles for increased stability and cellular internalization. We aimed to ...

    Authors: Huang-Ping Yu, Fu-Chao Liu, Ani Umoro, Zih-Chan Lin, Ahmed O. Elzoghby, Tsong-Long Hwang and Jia-You Fang

    Citation: Journal of Nanobiotechnology 2020 18:25

    Content type: Research

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  12. Targeted delivery of virus-associated antigens to professional antigen-presenting cells (APCs) is considered as an efficient strategy to enhance the pyrophytic effect of vaccines against rhabdovirus disease.

    Authors: Chen Zhang, Gao-Xue Wang and Bin Zhu

    Citation: Journal of Nanobiotechnology 2020 18:24

    Content type: Research

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  13. Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here descr...

    Authors: Seyed Mohammadali Dadfar, Denise Camozzi, Milita Darguzyte, Karolin Roemhild, Paola Varvarà, Josbert Metselaar, Srinivas Banala, Marcel Straub, Nihan Güvener, Ulrich Engelmann, Ioana Slabu, Miriam Buhl, Jan van Leusen, Paul Kögerler, Benita Hermanns-Sachweh, Volkmar Schulz…

    Citation: Journal of Nanobiotechnology 2020 18:22

    Content type: Research

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  14. Carbon nanoparticles (CNPs) have been reported to boost plant growth, while the mechanism that CNPs enhanced potassium uptake for plant growth has not been reported so far.

    Authors: Lijuan Chen, Jinchu Yang, Xiang Li, Taibo Liang, Cong Nie, Fuwei Xie, Kejian Liu, Xiaojun Peng and Jianping Xie

    Citation: Journal of Nanobiotechnology 2020 18:21

    Content type: Research

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  15. Extracellular vesicles (EVs) have shown great potential for targeted therapy, as they have a natural ability to pass through biological barriers and, depending on their origin, can preferentially accumulate at...

    Authors: Pablo Lara, Sujey Palma-Florez, Edison Salas-Huenuleo, Iva Polakovicova, Simón Guerrero, Lorena Lobos-Gonzalez, America Campos, Luis Muñoz, Carla Jorquera-Cordero, Manuel Varas-Godoy, Jorge Cancino, Eloísa Arias, Jaime Villegas, Luis J. Cruz, Fernando Albericio, Eyleen Araya…

    Citation: Journal of Nanobiotechnology 2020 18:20

    Content type: Research

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  16. Biodistribution of photosensitizer (PS) in photodynamic therapy (PDT) can be assessed by fluorescence imaging that visualizes the accumulation of PS in malignant tissue prior to PDT. At the same time, excitati...

    Authors: O. M. Chepurna, A. Yakovliev, R. Ziniuk, O. A. Nikolaeva, S. M. Levchenko, H. Xu, M. Y. Losytskyy, J. L. Bricks, Yu. L. Slominskii, L. O. Vretik, J. Qu and T. Y. Ohulchanskyy

    Citation: Journal of Nanobiotechnology 2020 18:19

    Content type: Research

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  17. Although accumulating evidence suggests that the crosstalk between malignant cells and cancer-associated fibroblasts (CAFs) actively contributes to tumour growth and metastatic dissemination, therapeutic strat...

    Authors: Dávid Kovács, Nóra Igaz, Annamária Marton, Andrea Rónavári, Péter Bélteky, László Bodai, Gabriella Spengler, László Tiszlavicz, Zsolt Rázga, Péter Hegyi, Csaba Vizler, Imre M. Boros, Zoltán Kónya and Mónika Kiricsi

    Citation: Journal of Nanobiotechnology 2020 18:18

    Content type: Research

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  18. This study aimed to develop a new colon-targeted drug delivery system via the preparation of ternary nanocomposite carriers based on organic polymer, aminoclay and lipid vesicles. Budesonide (Bud), an anti-inf...

    Authors: Hyeon Young Kim, Jae Hee Cheon, Sang Hoon Lee, Jeong Youn Min, Seung-Yun Back, Jae Geun Song, Da Hye Kim, Soo-Jeong Lim and Hyo-Kyung Han

    Citation: Journal of Nanobiotechnology 2020 18:17

    Content type: Research

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  19. The clustered regularly interspaced short palindromic repeats (CRISPR) and Cas9 protein system is a revolutionary tool for gene therapy. Despite promising reports of the utility of CRISPR–Cas9 for in vivo gene...

    Authors: Ami Jo, Veronica M. Ringel-Scaia, Dylan K. McDaniel, Cassidy A. Thomas, Rui Zhang, Judy S. Riffle, Irving C. Allen and Richey M. Davis

    Citation: Journal of Nanobiotechnology 2020 18:16

    Content type: Research

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  20. The successful deliveries of siRNA depend on their stabilities under physiological conditions because greater in vivo stability enhances cellular uptake and enables endosomal escape. Viral-based systems appear...

    Authors: Aena Yi, Dahye Sim, Young-Jin Lee, Vijaya Sarangthem and Rang-Woon Park

    Citation: Journal of Nanobiotechnology 2020 18:15

    Content type: Research

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  21. In orthopedics, the treatment of implant-associated infections represents a high challenge. Especially, potent antibacterial effects at implant surfaces can only be achieved by the use of high doses of antibio...

    Authors: Hilke Catherina Janßen, Nina Angrisani, Stefan Kalies, Florian Hansmann, Manfred Kietzmann, Dawid Peter Warwas, Peter Behrens and Janin Reifenrath

    Citation: Journal of Nanobiotechnology 2020 18:14

    Content type: Research

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  22. During the past few decades, drug delivery system (DDS) has attracted many interests because it could enhance the therapeutic effects of drugs and reduce their side effects. The advent of nanotechnology has pr...

    Authors: Ming Gao, Yifeng Yang, Andreas Bergfel, Lanli Huang, Li Zheng and Tim Melander Bowden

    Citation: Journal of Nanobiotechnology 2020 18:13

    Content type: Research

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  23. CD47, the integrin-related protein, plays an important role in immune resistance and escape of tumor cells. Antibodies blocking the CD47/SIRPα signal pathway can effectively stimulate macrophage-mediated phago...

    Authors: Linlin Ma, Min Zhu, Junwei Gai, Guanghui Li, Qing Chang, Peng Qiao, Longlong Cao, Wanqing Chen, Siyuan Zhang and Yakun Wan

    Citation: Journal of Nanobiotechnology 2020 18:12

    Content type: Research

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  24. In several years ago, infection with human papillomaviruses (HPVs), have been prevalent in the worlds especially HPV type 18, can lead to cervical cancer. Therefore, rapid, accurate, and early diagnosis of HPV...

    Authors: Pegah Mahmoodi, Majid Rezayi, Elisa Rasouli, Amir Avan, Mehrdad Gholami, Majid Ghayour Mobarhan, Ehsan Karimi and Yatima Alias

    Citation: Journal of Nanobiotechnology 2020 18:11

    Content type: Research

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  25. 5-Fluorouracil (5-FU) has been commonly prescribed for patients with colorectal cancer (CRC), but resistance to 5-FU is one of the main reasons for failure in CRC. Recently, microRNAs (miRNAs) have been establ...

    Authors: Gaofeng Liang, Yanliang Zhu, Doulathunnisa Jaffar Ali, Tian Tian, Huantian Xu, Ke Si, Bo Sun, Baoan Chen and Zhongdang Xiao

    Citation: Journal of Nanobiotechnology 2020 18:10

    Content type: Research

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  26. The vascular system, which transports oxygen and nutrients, plays an important role in wound healing, cardiovascular disease treatment and bone tissue engineering. Angiogenesis is a complex and delicate regula...

    Authors: Wenjing Liu, Guilan Zhang, Junrong Wu, Yanli Zhang, Jia Liu, Haiyun Luo and Longquan Shao

    Citation: Journal of Nanobiotechnology 2020 18:9

    Content type: Review

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  27. Chemotherapeutic drugs frequently encounter multidrug resistance. ATP from mitochondria helps overexpression of drug efflux pumps to induce multidrug resistance, so mitochondrial delivery as a means of “repurp...

    Authors: He Wang, Fangke Zhang, Huaying Wen, Wenwen Shi, Qiudi Huang, Yugang Huang, Jiacui Xie, Peiyin Li, Jianhai Chen, Linghao Qin and Yi Zhou

    Citation: Journal of Nanobiotechnology 2020 18:8

    Content type: Research

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  28. Antibodies are an important reagent to determine the specificity and accuracy of diagnostic immunoassays for various diseases. However, traditional antibodies have several shortcomings due to their limited abu...

    Authors: Qizhong Lu, Xiaoxuan Li, Jiakai Zhao, Jiahong Zhu, Yuhang Luo, Hong Duan, Pinpin Ji, Kun Wang, Baoyuan Liu, Xueting Wang, Wenqi Fan, Yani Sun, En-Min Zhou and Qin Zhao

    Citation: Journal of Nanobiotechnology 2020 18:7

    Content type: Research

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  29. Haptoglobin is an acute-phase protein used as predicting diagnostic biomarker both in humans (i.e., diabetes, ovarian cancer, some neurological and cardiovascular disorders) and in animals (e.g., bovine mastit...

    Authors: Narsingh R. Nirala, Yifat Harel, Jean-Paul Lellouche and Giorgi Shtenberg

    Citation: Journal of Nanobiotechnology 2020 18:6

    Content type: Research

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  30. Lipid nanocapsules (LNCs) are promising vehicles for drug delivery. However, since not much was known about cellular toxicity of these nanoparticles in themselves, we have here investigated the mechanisms invo...

    Authors: Marzena Szwed, Maria Lyngaas Torgersen, Remya Valsala Kumari, Sunil Kumar Yadava, Sascha Pust, Tore Geir Iversen, Tore Skotland, Jyotsnendu Giri and Kirsten Sandvig

    Citation: Journal of Nanobiotechnology 2020 18:5

    Content type: Research

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  31. Disulfiram (DSF) has been considered as “Repurposing drug” in cancer therapy in recent years based on its good antitumor efficacy. DSF is traditionally used as an oral drug in the treatment of alcoholism. To o...

    Authors: Haowen Li, Biao Liu, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo and Xiangtao Wang

    Citation: Journal of Nanobiotechnology 2020 18:4

    Content type: Research

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  32. Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic...

    Authors: Urszula Wnorowska, Krzysztof Fiedoruk, Ewelina Piktel, Suhanya V. Prasad, Magdalena Sulik, Marianna Janion, Tamara Daniluk, Paul B. Savage and Robert Bucki

    Citation: Journal of Nanobiotechnology 2020 18:3

    Content type: Review

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  33. After publication of this article, an error was found in the description of the holmium isotopes. 165Ho is a stable isotope a fraction of which is activated to 166Ho by neutron activation in a nuclear reactor [2]...

    Authors: Oleksii O. Peltek, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin

    Citation: Journal of Nanobiotechnology 2020 18:2

    Content type: Correction

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    The original article was published in Journal of Nanobiotechnology 2019 17:90

  34. Photoimmunotherapy involves targeted delivery of photosensitizers via an antibody conjugate (i.e., photoimmunoconjugate, PIC) followed by light activation for selective tumor killing. The trade-off between PIC...

    Authors: Barry J. Liang, Michael Pigula, Yan Baglo, Daniel Najafali, Tayyaba Hasan and Huang-Chiao Huang

    Citation: Journal of Nanobiotechnology 2020 18:1

    Content type: Research

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  35. An important but rarely addressed question in nano-therapy is to know whether bio-degraded nanoparticles with reduced sizes and weakened heating power are able to maintain sufficient anti-tumor activity to ful...

    Authors: Edouard Alphandéry, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Florence Gazeau, François Guyot and Imène Chebbi

    Citation: Journal of Nanobiotechnology 2019 17:126

    Content type: Research

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  36. Multidrug resistance (MDR) is a pressing obstacle in clinical chemotherapy for breast cancer. Based on the fact that the drug efflux is an important factor in MDR, we designed a codelivery system to guide the ...

    Authors: Yang Dong, Hongze Liao, Jian Yu, Hao Fu, De Zhao, Ke Gong, Qi Wang and Yourong Duan

    Citation: Journal of Nanobiotechnology 2019 17:125

    Content type: Research

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  37. Understanding the in vivo size-dependent pharmacokinetics and toxicity of nanoparticles is crucial to determine their successful development. Systematic studies on the size-dependent biological effects of nano...

    Authors: Jinquan Li, Zhongxue Yuan, Huili Liu, Jianghua Feng and Zhong Chen

    Citation: Journal of Nanobiotechnology 2019 17:124

    Content type: Research

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  38. Nanomedicine is a promising new approach to cancer treatment that avoids the disadvantages of traditional chemotherapy and improves therapeutic indices. However, the lack of a real-time visualization imaging t...

    Authors: Yanlong Jia, Chaochao Wang, Jiehua Zheng, Guisen Lin, Dalong Ni, Zhiwei Shen, Baoxuan Huang, Yan Li, Jitian Guan, Weida Hong, Yuanfeng Chen and Renhua Wu

    Citation: Journal of Nanobiotechnology 2019 17:123

    Content type: Research

    Published on:

  39. Obesity through its association with type 2 diabetes (T2D), cancer and cardiovascular diseases (CVDs), poses a serious health threat, as these diseases contribute to high mortality rates. Pharmacotherapy alone...

    Authors: Nicole Remaliah Samantha Sibuyi, Koena Leah Moabelo, Mervin Meyer, Martin Opiyo Onani, Admire Dube and Abram Madimabe Madiehe

    Citation: Journal of Nanobiotechnology 2019 17:122

    Content type: Review

    Published on:

  40. DNA methylation detection is indispensable for the diagnosis and prognosis of various diseases including malignancies. Hence, it is crucial to develop a simple, sensitive, and specific detection strategy.

    Authors: Shu Zhang, Jian Huang, Jingrun Lu, Min Liu, Yan Li, Lichao Fang, Hui Huang, Jianjun Huang, Fei Mo and Junsong Zheng

    Citation: Journal of Nanobiotechnology 2019 17:121

    Content type: Research

    Published on:

  41. Tamoxifen (Tam) is the most frequent treatment for estrogen receptor (ER) positive breast cancer. We recently showed that fibronectin (FN) leads to Tam resistance and selection of breast cancer stem cells. Wit...

    Authors: María Inés Diaz Bessone, Lorena Simón-Gracia, Pablo Scodeller, María de los Angeles Ramirez, María Amparo Lago Huvelle, Galo J. A. A. Soler-Illia and Marina Simian

    Citation: Journal of Nanobiotechnology 2019 17:120

    Content type: Research

    Published on:

  42. The functional preservation of the central nervous system (CNS) is based on the neuronal plasticity and survival. In this context, the neuroinflammatory state plays a key role and involves the microglial cells...

    Authors: Quentin Lemaire, Antonella Raffo-Romero, Tanina Arab, Christelle Van Camp, Francesco Drago, Stefano Forte, Jean-Pascal Gimeno, Séverine Begard, Morvane Colin, Jacopo Vizioli, Pierre-Eric Sautière, Michel Salzet and Christophe Lefebvre

    Citation: Journal of Nanobiotechnology 2019 17:119

    Content type: Research

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  43. Developing new strategies to reduce the output power of microwave (MW) ablation while keeping anti-tumor effect are highly desirable for the simultaneous achievement of effective tumor killing and avoidance of...

    Authors: Jian-ping Dou, Qiong Wu, Chang-hui Fu, Dong-yun Zhang, Jie Yu, Xian-wei Meng and Ping Liang

    Citation: Journal of Nanobiotechnology 2019 17:118

    Content type: Research

    Published on:

  44. Cancer cells always develop ways to resist and evade chemotherapy. To overcome this obstacle, herein, we introduce a programmatic release drug delivery system that imparts avoiding drug efflux and nuclear tran...

    Authors: Yanyan Li, Yongxia Zhai, Wei Liu, Kaixiang Zhang, Junjie Liu, Jinjin Shi and Zhenzhong Zhang

    Citation: Journal of Nanobiotechnology 2019 17:117

    Content type: Research

    Published on:

  45. Tumor cells with heterogeneity and diversity can express different markers. At present, positive separation of circulating tumor cells (CTC) taking EpCAM as the marker was used in most cases which could be one...

    Authors: Jingde Chen, Lin Chen, Shibin Du, Jing Wu, Ming Quan, Hua Yin, Yin Wu, Xuanting Ye, Xiaofei Liang and Hong Jiang

    Citation: Journal of Nanobiotechnology 2019 17:116

    Content type: Review

    Published on:

  46. We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of Cl...

    Authors: Beatrice Formicola, Roberta Dal Magro, Carlos V. Montefusco-Pereira, Claus-Michael Lehr, Marcus Koch, Laura Russo, Gianvito Grasso, Marco A. Deriu, Andrea Danani, Sandrine Bourdoulous and Francesca Re

    Citation: Journal of Nanobiotechnology 2019 17:115

    Content type: Short Communication

    Published on:

  47. The biological activity of MXenes has been studied for several years because of their potential biomedical applications; however, investigations have so far been limited to 2D titanium carbides. Although monol...

    Authors: A. Szuplewska, A. Rozmysłowska-Wojciechowska, S. Poźniak, T. Wojciechowski, M. Birowska, M. Popielski, M. Chudy, W. Ziemkowska, L. Chlubny, D. Moszczyńska, A. Olszyna, J. A. Majewski and A. M. Jastrzębska

    Citation: Journal of Nanobiotechnology 2019 17:114

    Content type: Research

    Published on:

  48. Synergistic therapy of tumor is a promising way in curing cancer and in order to achieve effective tumor therapy with real-time drug release monitoring, dynamic cellular imaging and antitumor activity.

    Authors: Chen Du, Yan Liang, Qingming Ma, Qianwen Sun, Jinghui Qi, Jie Cao, Shangcong Han, Mingtao Liang, Bo Song and Yong Sun

    Citation: Journal of Nanobiotechnology 2019 17:113

    Content type: Research

    Published on:

  49. Cerium oxide nanoparticles are effective scavengers of reactive oxygen species and have been proposed as a treatment for oxidative stress-related diseases. Consequently, we aimed to investigate the effect of t...

    Authors: Bernat Córdoba-Jover, Altamira Arce-Cerezo, Jordi Ribera, Montse Pauta, Denise Oró, Gregori Casals, Guillermo Fernández-Varo, Eudald Casals, Victor Puntes, Wladimiro Jiménez and Manuel Morales-Ruiz

    Citation: Journal of Nanobiotechnology 2019 17:112

    Content type: Research

    Published on:

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