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  1. The prevalence of end-stage kidney disease (ESKD) is rapidly increasing with the need for regenerative therapies. Adult stem cell derived kidney tubuloids have the potential to functionally mimic the adult kid...

    Authors: Rafael Soares Lindoso, Fjodor A. Yousef Yengej, Franziska Voellmy, Maarten Altelaar, Estela Mancheño Juncosa, Theano Tsikari, Carola M. E. Ammerlaan, Bas W. M. Van Balkom, Maarten B. Rookmaaker, Marianne C. Verhaar and Rosalinde Masereeuw
    Citation: Journal of Nanobiotechnology 2022 20:326
  2. Building a novel and efficient photothermal antibacterial nanoplatform is a promising strategy for precise bacterial elimination. Herein, a nanocomposite NiO NPs@AuNPs@Van (NAV) for selective MRSA removal was ...

    Authors: Ting Du, Jiangli Cao, Zehui Xiao, Jiaqi Liu, Lifei Wei, Chunqiao Li, Jingbo Jiao, Zhiyong Song, Jifeng Liu, Xinjun Du and Shuo Wang
    Citation: Journal of Nanobiotechnology 2022 20:325
  3. Chronic inflammatory pain significantly reduces the quality of life and lacks effective interventions. In recent years, human umbilical cord mesenchymal stem cells (huc-MSCs)-derived exosomes have been used to...

    Authors: Tong Hua, Mei Yang, Honghao Song, Erliang Kong, Mengqiu Deng, Yongchang Li, Jian Li, Zhixiao Liu, Hailong Fu, Yue Wang and Hongbin Yuan
    Citation: Journal of Nanobiotechnology 2022 20:324
  4. In hypoxic dendritic cells (DCs), a low level of Zn2+ can induce the activation of immunogenic DCs (igDCs), thereby triggering an active T-cell response to propel the immune progression of rheumatoid arthritis (R...

    Authors: Han Qiao, Jingtian Mei, Kai Yuan, Kai Zhang, Feng Zhou, Tingting Tang and Jie Zhao
    Citation: Journal of Nanobiotechnology 2022 20:323
  5. Alzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early d...

    Authors: Yuting Ruan, Ying Xiong, Wenli Fang, Qun Yu, Yingren Mai, Zhiyu Cao, Kexi Wang, Ming Lei, Jiaxin Xu, Yan Liu, Xingcai Zhang, Wang Liao and Jun Liu
    Citation: Journal of Nanobiotechnology 2022 20:322
  6. Enterococcus faecalis (E. faecalis) biofilm-associated persistent endodontic infections (PEIs) are one of the most common tooth lesions, causing chronic periapical periodontitis, root resorption, and even tooth ...

    Authors: Shang Tang, Hui Zhang, Li Mei, Keke Dou, Yuying Jiang, Zhanyi Sun, Shuai Wang, Mohamed Sayed Hasanin, Jing Deng and Qihui Zhou
    Citation: Journal of Nanobiotechnology 2022 20:321
  7. Nanovaccines have shown the promising potential in controlling and eradicating the threat of infectious diseases worldwide. There has been a great need in developing a versatile strategy to conveniently constr...

    Authors: Sisi Chen, Liu Yang, Xia Ou, Jin-Yu Li, Cheng-Ting Zi, Hao Wang, Jiang-Miao Hu and Ye Liu
    Citation: Journal of Nanobiotechnology 2022 20:320
  8. Chemoresistance is often a cause of the failure of chemotherapy in cancer treatment. Sorcin (SRI) is a soluble resistance-related calcium-binding protein involved in chemoresistant processes and is overexpress...

    Authors: Chenglong Wang, Xiaolin Xu, Peipei Zhang, Shuhan Xiong, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Hongjing Dou and Guoxiong Xu
    Citation: Journal of Nanobiotechnology 2022 20:319
  9. Cerebral malaria (CM) is a life-threatening neurological complication caused by Plasmodium falciparum. About 627,000 patients died of malaria in 2020. Currently, artemisinin and its derivatives are the front-l...

    Authors: Ya Tian, Zhongyuan Zheng, Xi Wang, Shuzhi Liu, Liwei Gu, Jing Mu, Xiaojun Zheng, Yujie Li and Shuo Shen
    Citation: Journal of Nanobiotechnology 2022 20:318
  10. Exosomes are nano-sized vesicles secreted by various cells into the intra and extracellular space and hence is an integral part of biological fluids including milk. In the last few decades, many research group...

    Authors: Vengala Rao Yenuganti, Sumbul Afroz, Rafiq Ahmad Khan, Chandrima Bharadwaj, Deepti Kailash Nabariya, Nagaraj Nayak, Madhuri Subbiah, Kumaraswami Chintala, Sharmistha Banerjee, Pallu Reddanna and Nooruddin Khan
    Citation: Journal of Nanobiotechnology 2022 20:317
  11. Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest malignant tumors with features of matrix barrier caused poor drug permeability, and susceptibility to drug resistance. Herein, a PDAC and its stro...

    Authors: Kaiwei Xu, Lufei Jin, Liu Xu, Yuchao Zhu, Lu Hong, Chunshu Pan, Yanying Li, Junlie Yao, Ruifen Zou, Weiwei Tang, Jianhua Wang, Aiguo Wu and Wenzhi Ren
    Citation: Journal of Nanobiotechnology 2022 20:315
  12. Acute respiratory distress syndrome (ARDS), caused by noncardiogenic pulmonary edema (PE), contributes significantly to Coronavirus 2019 (COVID-19)-associated morbidity and mortality. We explored the effect of...

    Authors: ZhiZhi Qian, QianYi Wang, ZhaoShun Qiu, DanYang Li, ChenCheng Zhang, XiYu Xiong, ZiHui Zheng, QinLi Ruan, YiChen Guo and Jun Guo
    Citation: Journal of Nanobiotechnology 2022 20:314
  13. Metastasis is one of the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Abnormally estrogen level and activated platelets are the key driving forces for TNBC metastasis. Herei...

    Authors: Sijie Wang, Na Yin, Yongjuan Li, Tingting Xiang, Wenxiao Jiang, Xiu Zhao, Wei Liu, Zhenzhong Zhang, Jinjin Shi, Kaixiang Zhang, Xingming Guo, Pilei Si and Junjie Liu
    Citation: Journal of Nanobiotechnology 2022 20:313
  14. Bacterial infection in wounds has become a major threat to human life and health. With the growth use of synthetic antibiotics and the elevated evolution of drug resistant bacteria in human body cells requires...

    Authors: Guihua Yang, Zhikun Zhang, Kefeng Liu, Xingxiang Ji, Pedram Fatehi and Jiachuan Chen
    Citation: Journal of Nanobiotechnology 2022 20:312
  15. The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult....

    Authors: Li-Xing Yang, Yu-Cheng Liu, Chang-Hui Cho, Yi-Rou Chen, Chan-Shan Yang, Yin-Lin Lu, Zhiming Zhang, Yi-Tseng Tsai, Yu-Cheng Chin, Jiashing Yu, Hsiu-Min Pan, Wei-Rou Jiang, Zi-Chun Chia, Wei-Shiang Huang, Yu-Lin Chiu, Chun-Kai Sun…
    Citation: Journal of Nanobiotechnology 2022 20:311
  16. Cancer is one of the significant threats to human life. Although various latest technologies are currently available to treat cancer, it still accounts for millions of death each year worldwide. Thus, creating...

    Authors: Madhusudhan Alle, Garima Sharma, Seung-Hwan Lee and Jin-Chul Kim
    Citation: Journal of Nanobiotechnology 2022 20:222
  17. Hydrogels based on organic/inorganic composites have been at the center of attention for the fabrication of engineered bone constructs. The establishment of a straightforward 3D microenvironment is critical to...

    Authors: Ayla Hassani, Çığır Biray Avci, Sajed Nazif Kerdar, Hassan Amini, Meisam Amini, Mahdi Ahmadi, Shinji Sakai, Bakiye Goker Bagca, Neslihan Pınar Ozates, Reza Rahbarghazi and Ali Baradar Khoshfetrat
    Citation: Journal of Nanobiotechnology 2022 20:310
  18. Diabetic foot ulcer (DFU), persistent hyperglycemia and inflammation, together with impaired nutrient and oxygen deficiency, can present abnormal angiogenesis following tissue injury such that these tissues fa...

    Authors: Xi Chen, Yizhong Peng, Hang Xue, Guohui Liu, Ning Wang and Zengwu Shao
    Citation: Journal of Nanobiotechnology 2022 20:309
  19. Diabetes mellitus (DM) is a disease caused by dysfunction or disruption of pancreatic islets. The advent and development of microfluidic organoids-on-a-chip platforms have facilitated reproduce of complex and ...

    Authors: Jiaxiang Yin, Hao Meng, Jingfang Lin, Wei Ji, Tao Xu and Huisheng Liu
    Citation: Journal of Nanobiotechnology 2022 20:308
  20. Therapy with genetically modified mesenchymal stem cells (MSCs) has clinical translation promise. Optimizing the targeting migratory ability of MSCs relies on accurate imaging of the distribution and extravasa...

    Authors: Yuejun Lin, Hui-chao Zhou, Ningbo Chen, Yaguang Ren, Rongkang Gao, Qiaojia Li, Yiwen Deng, Xuejiao Han, Xiaoran Zhang, Andy Peng Xiang, Bing Guo, Chengbo Liu and Jie Ren
    Citation: Journal of Nanobiotechnology 2022 20:307
  21. Protein-stabilized gold nanoclusters (Prot-Au NCs) have been widely used in biosensing and cell imaging owing to their excellent optical properties and low biotoxicity. However, several Prot-Au NCs reported in...

    Authors: Zhenrong Tang, Fengjiao Chen, Dan Wang, Dongmei Xiong, Shaoying Yan, Shengchun Liu and Hua Tang
    Citation: Journal of Nanobiotechnology 2022 20:306
  22. Muscle atrophy is a frequently observed complication, characterized by the loss of muscle mass and strength, which diminishes the quality of life and survival. No effective therapy except exercise is currently...

    Authors: Rui Chen, Weilin Yuan, Yongjun Zheng, Xiaolan Zhu, Bing Jin, Tingting Yang, Yuwei Yan, Wanru Xu, Hongjian Chen, Juan Gao, Guoping Li, Priyanka Gokulnath, Gururaja Vulugundam, Jin Li and Junjie Xiao
    Citation: Journal of Nanobiotechnology 2022 20:304
  23. Loss of extracellular matrix (ECM) of cartilage due to oxidative stress injury is one of the main characteristics of osteoarthritis (OA). As a bioactive molecule derived from the traditional Chinese Burdock, arct...

    Authors: Yang Liu, Mingzhuang Hou, Zejun Pan, Xin Tian, Zhijian Zhao, Tao Liu, Huilin Yang, Qin Shi, Xi Chen, Yijian Zhang, Fan He and Xuesong Zhu
    Citation: Journal of Nanobiotechnology 2022 20:303
  24. Heavy metals repress tobacco growth and quality, and engineered nanomaterials have been used for sustainable agriculture. However, the underlying mechanism of nanoparticle-mediated cadmium (Cd) toxicity in tob...

    Authors: Congming Zou, Tianquan Lu, Ruting Wang, Peng Xu, Yifen Jing, Ruling Wang, Jin Xu and Jinpeng Wan
    Citation: Journal of Nanobiotechnology 2022 20:302
  25. Photoluminescent nanomaterials have been widely employed in several biological applications both in vitro and in vivo. For the first time, we report a novel application of sour apple-derived photoluminescent c...

    Authors: Xiang Li, Yang Lu, Jiarui Li, Shengji Zhou, Yuxin Wang, Liangping Li and Fengchao Zhao
    Citation: Journal of Nanobiotechnology 2022 20:301
  26. Deep tumor cells (cells in the center of solid tumors) play a crucial role in drug tolerance, metastasis, recurrence and microenvironment immune suppression. However, their deep location endows them with an un...

    Authors: Fengling Wang, Dandan Xie, Wenjing Lai, Min Zhou, Jie Wang, Rufu Xu, Jingbing Huang, Rong Zhang and Guobing Li
    Citation: Journal of Nanobiotechnology 2022 20:300
  27. Traumatic brain injury (TBI) is a cause of disability and death worldwide, but there are currently no specific treatments for this condition. Release of excess reactive oxygen species (ROS) in the injured brai...

    Authors: Shengyang Fu, Shu Zhao, Huili Chen, Weitao Yang, Xiaohuan Xia, Xiaonan Xu, Zhanping Liang, Xuanran Feng, Zhuo Wang, Pu Ai, Lu Ding, Qingyuan Cai, Yi Wang, Yanyan Zhang, Jie Zhu, Bingbo Zhang…
    Citation: Journal of Nanobiotechnology 2022 20:299
  28. In this study, we used the nanoparticle delivery system to reduce the side effect of conventional cancer treatment- radiation therapy and chemotherapy. We used rice husk silicon source mesoporous silica nanopa...

    Authors: Zui-Harng Lee, Meng-Feng Lee, Jung-Huang Chen, Min-Hsuan Tsou, Zhi-Yuan Wu, Cheng-Zhang Lee, Yu-Ya Huang, Showe-Mei Lin and Hsiu-Mei Lin
    Citation: Journal of Nanobiotechnology 2022 20:298
  29. Phototherapy-triggered immunogenic cell death (ICD) rarely elicits a robust antitumour immune response, partially due to low antigen exposure and inefficient antigen presentation. To address these issues, we d...

    Authors: Xiao Xu, Huafen Mao, Yunchao Wu, Suwan Liu, Jingjin Liu, Qianzhe Li, Mengyu Yang, Jinqian Zhu, Shengqiang Zou and Fengyi Du
    Citation: Journal of Nanobiotechnology 2022 20:297
  30. Skin thickness is closely related to the appearance of human skin, such as sagging and wrinkling, which primarily depends on the level of collagen I synthesized by dermal fibroblasts (DFs). Small extracellular...

    Authors: Qin Zou, Mei Zhang, Rong Yuan, Yifei Wang, Zhengyin Gong, Rui Shi, Yujing Li, Kaixin Fei, Chenggang Luo, Ying Xiong, Ting Zheng, Li Zhu, Guoqing Tang, Mingzhou Li, Xuewei Li and Yanzhi Jiang
    Citation: Journal of Nanobiotechnology 2022 20:296
  31. With rich carboxyl groups in the side chain, biodegradable polymalic acid (PMLA) is an ideal delivery platform for multifunctional purposes, including imaging diagnosis and targeting therapy. This polymeric ma...

    Authors: Xing Huang, Liusheng Xu, Hui Qian, Xinghuan Wang and Zhimin Tao
    Citation: Journal of Nanobiotechnology 2022 20:295
  32. Diabetic wound is the leading cause of non-traumatic amputations in which oxidative stress and chronic inflammation are main factors affecting wound healing. Although mesenchymal stem cells (MSCs) as living ma...

    Authors: Shaoying Gao, Tao Chen, Zhen Wang, Ping Ji, Lin Xu, Wenguo Cui and Ying Wang
    Citation: Journal of Nanobiotechnology 2022 20:294
  33. Radiation therapy is one of the most commonly used methods in clinical cancer treatment, and radiosensitizers could achieve enhanced therapeutic efficacy by incorporating heavy elements into structures. Howeve...

    Authors: Lei Chen, Jinghui Zhang, Lihua Xu, Luchao Zhu, Jinpeng Jing, Yushuo Feng, Zongzhang Wang, Peifei Liu, Wenjing Sun, Xiangmei Liu, Yimin Li and Hongmin Chen
    Citation: Journal of Nanobiotechnology 2022 20:293
  34. Increasing evidence suggests that platelets play a central role in cancer progression, with altered storage and selective release from platelets of specific tumor-promoting proteins as a major mechanism. Fluor...

    Authors: Jan Bergstrand, Xinyan Miao, Chinmaya Venugopal Srambickal, Gert Auer and Jerker Widengren
    Citation: Journal of Nanobiotechnology 2022 20:292
  35. The use of keratinocytes derived from induced pluripotent stem cells (iPSCs-KCs) may represent a novel cell therapy strategy for burn treatment. There is growing evidence that extracellular vesicles, including...

    Authors: Yunyao Bo, Lijun Yang, Baiting Liu, Guiping Tian, Chenxi Li, Lin Zhang and Yuan Yan
    Citation: Journal of Nanobiotechnology 2022 20:291
  36. Pain is a vital sense that indicates the risk of injury at a particular body part. Successful control of pain is the principal aspect in medical treatment. In recent years, the advances of nanotechnology in pa...

    Authors: Soraya Babaie, Arezou Taghvimi, Joo-Hyun Hong, Hamed Hamishehkar, Seongpil An and Ki Hyun Kim
    Citation: Journal of Nanobiotechnology 2022 20:290
  37. Inorganic nanoparticles (INPs) have been paid great attention in the field of oncology in recent past years since they have enormous potential in drug delivery, gene delivery, photodynamic therapy (PDT), photo...

    Authors: Wanli Song, Pengfei Jia, Ting Zhang, Keke Dou, Lubin Liu, Yaping Ren, Fujun Liu, Junmiao Xue, Mohamed Sayed Hasanin, Hongzhao Qi and Qihui Zhou
    Citation: Journal of Nanobiotechnology 2022 20:289
  38. Radiation-induced skin injury (RISI) is a common complication of radiotherapy. Interferon-alpha inducible protein 6 (IFI6) significantly reduces the radiation sensitivity of HaCaT cells. Sodium alginate (SA) h...

    Authors: Jie Hao, Mengyi Sun, Dong Li, Tao Zhang, Jianjun Li and Daijun Zhou
    Citation: Journal of Nanobiotechnology 2022 20:288
  39. Nowadays, brain tumors are challenging problems, and the key of therapy is ensuring therapeutic drugs cross the blood–brain barrier (BBB) effectively. Although the efficiency of drug transport across the BBB c...

    Authors: Shuo Zhang, Shuai Zhang, Siyuan Luo, Peng Tang, Mingxi Wan, Daocheng Wu and Wei Gao
    Citation: Journal of Nanobiotechnology 2022 20:287
  40. Circulating miRNAs in the blood can regulate disease development and thus indicate disease states via their various expression levels. For these reasons, circulating miRNAs constitute useful biomarkers, and an...

    Authors: Yudie Sun, La Fang, Yang Yi, Aobo Feng, Kui Zhang and Jing-Juan Xu
    Citation: Journal of Nanobiotechnology 2022 20:285
  41. Glioblastoma (GBM) as the most common primary malignant brain tumor exhibits a high incidence and degree of malignancy as well as poor prognosis. Due to the existence of formidable blood–brain barrier (BBB) an...

    Authors: Danping Zhuang, Huifen Zhang, Genwen Hu and Bing Guo
    Citation: Journal of Nanobiotechnology 2022 20:284
  42. Sonodynamic therapy (SDT) induces immunogenic cell death (ICD) in tumors and promises to play an assistive role in immunotherapy in pancreatic cancer. However, the short half-life and limited diffusion distanc...

    Authors: Jifan Chen, Liting Feng, Peile Jin, Jiaxin Shen, Jiayue Lu, Yue Song, Guowei Wang, Qin Chen, Deyi Huang, Ying Zhang, Chao Zhang, Youfeng Xu and Pintong Huang
    Citation: Journal of Nanobiotechnology 2022 20:283
  43. Nanotopographical cues play a critical role as drivers of mesenchymal stem cell differentiation. Nanowire scaffolds, in this regard, provide unique and adaptable nanostructured surfaces with focal points for a...

    Authors: Jose E. Perez, Bashaer Bajaber, Nouf Alsharif, Aldo I. Martínez-Banderas, Niketan Patel, Ainur Sharip, Enzo Di Fabrizio, Jasmeen Merzaban and Jürgen Kosel
    Citation: Journal of Nanobiotechnology 2022 20:282
  44. Oral chemotherapy is preferred for patients with cancer owing to its multiple advantages, including convenience, better patient compliance, and improved safety. Nevertheless, various physical barriers exist in...

    Authors: Wei Liu, Ying Han, Xin Xin, Liqing Chen, Yanhong Liu, Chao Liu, Xintong Zhang, Mingji Jin, Jingzhe Jin, Zhonggao Gao and Wei Huang
    Citation: Journal of Nanobiotechnology 2022 20:281
  45. As an antioxidant, hydrogen (H2) can selectively react with the highly toxic hydroxyl radical (·OH) in tumor cells to break the balance of reactive oxygen species (ROS) and cause oxidative stress. However, due to...

    Authors: Hongyu Yan, Miao Fan, Huifang Liu, Tingshan Xiao, Dandan Han, Ruijun Che, Wei Zhang, Xiaohan Zhou, June Wang, Chi Zhang, Xinjian Yang, Jinchao Zhang and Zhenhua Li
    Citation: Journal of Nanobiotechnology 2022 20:280
  46. Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor ...

    Authors: Ying Zhang, Qiqi Liu, Xinmeng Zhang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Zhourui Xu, Meirong Li, Xin Chen, Jia Liu and Chengbin Yang
    Citation: Journal of Nanobiotechnology 2022 20:279
  47. Cancer immunotherapy is a novel therapeutic regimen because of the specificity and durability of immune modulations to treat cancers. Current cancer immunotherapy is limited by some barriers such as poor respo...

    Authors: Su-Ran Li, Fang-Yi Huo, Han-Qi Wang, Jing Wang, Chun Xu, Bing Liu and Lin-Lin Bu
    Citation: Journal of Nanobiotechnology 2022 20:277

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