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  1. Content type: Research

    Theranostic perfluorocarbon nanoprobes have recently attracted attention due to their fascinating versatility in integrating diagnostics and therapeutics into a single system. Furthermore, although 17β-estradi...

    Authors: Xueli Zhao, Wen Luo, Jing Hu, Lei Zuo, Jing Wang, Rui Hu, Bo Wang, Lei Xu, Jing Li, Meng Wu, Pan Li and Liwen Liu

    Citation: Journal of Nanobiotechnology 2018 16:36

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  2. Content type: Research

    Cilomilast is a phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory lung diseases. This agent has a narrow therapeutic index with significant adverse effects on the nervous system. This study was co...

    Authors: Fu-Chao Liu, Huang-Ping Yu, Cheng-Yu Lin, Ahmed O. Elzoghby, Tsong-Long Hwang and Jia-You Fang

    Citation: Journal of Nanobiotechnology 2018 16:35

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  3. Content type: Research

    Peptide-drug-conjugates (PDCs) are being developed as an effective strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges to their successful application is the relativ...

    Authors: Kalishwaralal Kalimuthu, Bat-Chen Lubin, Andrii Bazylevich, Gary Gellerman, Ofer Shpilberg, Galia Luboshits and Michael A. Firer

    Citation: Journal of Nanobiotechnology 2018 16:34

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  4. Content type: Research

    Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as...

    Authors: Inmaculada Dalmau-Mena, Pablo del Pino, Beatriz Pelaz, Miguel Ángel Cuesta-Geijo, Inmaculada Galindo, María Moros, Jesús M. de la Fuente and Covadonga Alonso

    Citation: Journal of Nanobiotechnology 2018 16:33

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  5. Content type: Research

    Memantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to ...

    Authors: Elena Sánchez-López, Miren Ettcheto, Maria Antonia Egea, Marta Espina, Amanda Cano, Ana Cristina Calpena, Antoni Camins, Nuria Carmona, Amélia M. Silva, Eliana B. Souto and Maria Luisa García

    Citation: Journal of Nanobiotechnology 2018 16:32

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  6. Content type: Research

    Synthesis of silver nano-compounds with enhanced antimicrobial effects is of great interest for the development of new antibacterial agents. Previous studies have reported the antibacterial properties of pegyl...

    Authors: Seong B. Park, Christy S. Steadman, Atul A. Chaudhari, Shreekumar R. Pillai, Shree R. Singh, Peter L. Ryan, Scott T. Willard and Jean M. Feugang

    Citation: Journal of Nanobiotechnology 2018 16:31

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  7. Content type: Research

    The rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and...

    Authors: Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, Shizhen Chen and Xin Zhou

    Citation: Journal of Nanobiotechnology 2018 16:30

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  8. Content type: Research

    Gene therapy has been developed and used in medical treatment for many years, especially for the enhancement of endothelialization and angiogenesis. But slow endosomal escape rate is still one of the major bar...

    Authors: Qian Li, Xuefang Hao, Syed Saqib Ali Zaidi, Jintang Guo, Xiangkui Ren, Changcan Shi, Wencheng Zhang and Yakai Feng

    Citation: Journal of Nanobiotechnology 2018 16:29

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  9. Content type: Research

    The systemic administration of cytotoxic chemotherapeutic agents for cancer treatment often has toxic side effects, limiting the usage dose. To increase chemotherapeutic efficacy while reducing toxic effects, ...

    Authors: Ashraf Alemi, Javad Zavar Reza, Fateme Haghiralsadat, Hossein Zarei Jaliani, Mojtaba Haghi Karamallah, Seyed Ahmad Hosseini and Somayeh Haghi Karamallah

    Citation: Journal of Nanobiotechnology 2018 16:28

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  10. Content type: Research

    Vascular homeostasis is ensured by a dynamic interplay involving the endothelium, the platelets and the coagulation system. Thus, the vascular safety of particulate materials must address this integrated syste...

    Authors: Catarina Santos, Suzy Turiel, Pedro Sousa Gomes, Elísio Costa, Alice Santos-Silva, Paulo Quadros, José Duarte, Sílvia Battistuzzo and Maria Helena Fernandes

    Citation: Journal of Nanobiotechnology 2018 16:27

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  11. Content type: Research

    Breast cancer is the second leading cause of cancer death among women and represents 14% of death in women around the world. The standard diagnosis method for breast tumor is mammography, which is often relate...

    Authors: Akhil Jain, Pierrick G. J. Fournier, Vladimir Mendoza-Lavaniegos, Prakhar Sengar, Fernando M. Guerra-Olvera, Enrique Iñiguez, Thomas G. Kretzschmar, Gustavo A. Hirata and Patricia Juárez

    Citation: Journal of Nanobiotechnology 2018 16:26

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  12. Content type: Research

    The size and receptor-binding abilities of plasma lipoproteins are closely related with their structure/functions. Presently, the sizes of native lipoproteins have been measured by various methods including at...

    Authors: Chaoye Gan, Kun Wang, Qisheng Tang and Yong Chen

    Citation: Journal of Nanobiotechnology 2018 16:25

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  13. Content type: Research

    Nanotechnology-based drug delivery systems have been widely used for oral and systemic dosage forms delivery depending on the mucoadhesive interaction, and keratin has been applied for biomedical applications ...

    Authors: Zhongjun Cheng, Xiaoliang Chen, Dongliang Zhai, Feiyan Gao, Tingwang Guo, Wenfeng Li, Shilei Hao, Jingou Ji and Bochu Wang

    Citation: Journal of Nanobiotechnology 2018 16:24

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  14. Content type: Research

    Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in viv...

    Authors: Menglong Liu, Danfeng He, Tao Yang, Wei Liu, Li Mao, Yang Zhu, Jun Wu, Gaoxing Luo and Jun Deng

    Citation: Journal of Nanobiotechnology 2018 16:23

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  15. Content type: Research

    Recent work has developed solid drug nanoparticles (SDNs) of efavirenz that have been demonstrated, preclinically, improved oral bioavailability and the potential to enable up to a 50% dose reduction, and is c...

    Authors: Neill J. Liptrott, Marco Giardiello, Tom O. McDonald, Steve P. Rannard and Andrew Owen

    Citation: Journal of Nanobiotechnology 2018 16:22

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  16. Content type: Research

    Near-infrared quantum dots (NIR QDs) are a new class of fluorescent labels with excellent bioimaging features, such as high fluorescence intensity, good fluorescence stability, sufficient electron density, and...

    Authors: Jlenia Brunetti, Giulia Riolo, Mariangela Gentile, Andrea Bernini, Eugenio Paccagnini, Chiara Falciani, Luisa Lozzi, Silvia Scali, Lorenzo Depau, Alessandro Pini, Pietro Lupetti and Luisa Bracci

    Citation: Journal of Nanobiotechnology 2018 16:21

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  17. Content type: Research

    Due to the increased emergence of antimicrobial resistance, alternatives to minimize the usage of antibiotics become attractive solutions. Biophysical manipulation of material surface topography to prevent bac...

    Authors: Songmei Wu, Flavia Zuber, Katharina Maniura-Weber, Juergen Brugger and Qun Ren

    Citation: Journal of Nanobiotechnology 2018 16:20

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  18. Content type: Research

    Photodynamic therapy is a promising cancer therapy modality but its application for deep-seated tumor is mainly hindered by the shallow penetration of visible light. X-ray-mediated photodynamic therapy (PDT) h...

    Authors: Prakhar Sengar, Patricia Juárez, Andrea Verdugo-Meza, Danna L. Arellano, Akhil Jain, Kanchan Chauhan, Gustavo A. Hirata and Pierrick G. J. Fournier

    Citation: Journal of Nanobiotechnology 2018 16:19

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  19. Content type: Research

    Recent advances in nanomedicine have shown the great interest of active targeting associated to nanoparticles. Single chain variable fragments (scFv) of disease-specific antibodies are very promising targeting...

    Authors: Christophe Alric, Katel Hervé-Aubert, Nicolas Aubrey, Souad Melouk, Laurie Lajoie, William Même, Sandra Même, Yann Courbebaisse, Anastasia A. Ignatova, Alexey V. Feofanov, Igor Chourpa and Emilie Allard-Vannier

    Citation: Journal of Nanobiotechnology 2018 16:18

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  20. Content type: Research

    Tamoxifen is the standard endocrine therapy for breast cancers, which require metabolic activation by cytochrome P450 enzymes (CYP). However, the lower and variable concentrations of CYP activity at the tumor ...

    Authors: Kanchan Chauhan, Juan M. Hernandez-Meza, Ana G. Rodríguez-Hernández, Karla Juarez-Moreno, Prakhar Sengar and Rafael Vazquez-Duhalt

    Citation: Journal of Nanobiotechnology 2018 16:17

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  21. Content type: Research

    Understanding the molecular mechanisms of nanomaterial interacting with cellular systems is important for appropriate risk assessment. The identification of early biomarkers for potential (sub-)chronic effects...

    Authors: Daniela Schwotzer, Monika Niehof, Dirk Schaudien, Heiko Kock, Tanja Hansen, Clemens Dasenbrock and Otto Creutzenberg

    Citation: Journal of Nanobiotechnology 2018 16:16

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  22. Content type: Research

    Elastin-like polypeptides (ELPs) are a fascinating biomaterial that has undergone copious development for a variety of therapeutic applications including as a nanoscale drug delivery vehicle. A comprehensive u...

    Authors: Markian S. Bahniuk, Abdullah K. Alshememry, Scott V. Elgersma and Larry D. Unsworth

    Citation: Journal of Nanobiotechnology 2018 16:15

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  23. Content type: Research

    Oxidative stress acts as a trigger in the course of neurodegenerative diseases and neural injuries. An antioxidant-based therapy can be effective to ameliorate the deleterious effects of oxidative stress. Resv...

    Authors: Yang Shen, Bin Cao, Noah R. Snyder, Kevin M. Woeppel, James R. Eles and Xinyan Tracy Cui

    Citation: Journal of Nanobiotechnology 2018 16:13

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  24. Content type: Research

    The process of optimization and fabrication of nanoparticle synthesis for preclinical studies can be challenging and time consuming. Traditional small scale laboratory synthesis techniques suffer from batch to...

    Authors: Andrew Gdowski, Kaitlyn Johnson, Sunil Shah, Ignacy Gryczynski, Jamboor Vishwanatha and Amalendu Ranjan

    Citation: Journal of Nanobiotechnology 2018 16:12

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  25. Content type: Research

    Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such...

    Authors: Hui Chen, Jane P. M. Ng, Yi Tan, Kristine McGrath, David P. Bishop, Brian Oliver, Yik Lung Chan, Michael B. Cortie, Bruce K. Milthorpe and Stella M. Valenzuela

    Citation: Journal of Nanobiotechnology 2018 16:11

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  26. Content type: Research

    Ag+ and Zn2+ have already been used in combinations to obtain both enhanced antibacterial effect and low cytotoxicity. Despite this, it is still unclear how the Zn2+ co-works with Ag+ in the synergistic antibacte...

    Authors: Wei Fan, Qing Sun, Yanyun Li, Franklin R. Tay and Bing Fan

    Citation: Journal of Nanobiotechnology 2018 16:10

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  27. Content type: Research

    In the photodynamic therapy (PDT), the photosensitizer absorbs light and transfers the energy of the excited state to the oxygen in the cell environment producing reactive oxygen species (ROS), that in its tur...

    Authors: Mayara Simonelly Costa dos Santos, Ana Luisa Gouvêa, Ludmilla David de Moura, Leonardo Giordano Paterno, Paulo Eduardo Narcizo de Souza, Ana Paula Bastos, Emanuel Adelino Medeiros Damasceno, Fabiane Hiratsuka Veiga-Souza, Ricardo Bentes de Azevedo and Sônia Nair Báo

    Citation: Journal of Nanobiotechnology 2018 16:9

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  28. Content type: Research

    Trueperella pyogenes is a commensal and opportunistic pathogen that normally causes mastitis, liver abscesses and pneumonia of economically important livestock. To develop efficacious and potent vaccine against T...

    Authors: Ting Huang, Xuhao Song, Jie Jing, Kelei Zhao, Yongmei Shen, Xiuyue Zhang and Bisong Yue

    Citation: Journal of Nanobiotechnology 2018 16:8

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  29. Content type: Research

    Pancreatic cancer remains the leading cause of cancer-related deaths, the existence of cancer stem cells and lack of highly efficient early detection may account for the poor survival rate. Gadolinium ion-dope...

    Authors: Yong Han, Yanli An, Gang Jia, Xihui Wang, Chen He, Yinan Ding and Qiusha Tang

    Citation: Journal of Nanobiotechnology 2018 16:7

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  30. Content type: Research

    Gold nanoparticles are useful candidate for drug delivery applications and are associated with enhancement in the bioavailability of coated drugs and/or therapeutic agent. Since, heterocyclic compounds are kno...

    Authors: Ayaz Anwar, Sadia Khalid, Samina Perveen, Shakil Ahmed, Ruqaiyyah Siddiqui, Naveed Ahmed Khan and Muhammad Raza Shah

    Citation: Journal of Nanobiotechnology 2018 16:6

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  31. Content type: Correction

    Following publication of our article [1], we became aware that Roberto Di Gesù had been omitted from the list of authors. The corrected author list and authors’ contribution statement appear below. We apologize f...

    Authors: Roberto Di Gesù, Maria Luisa Bondì, Antonina Azzolina, Emanuela Fabiola Craparo, Chiara Botto, Erika Amore, Gaetano Giammona and Melchiorre Cervello

    Citation: Journal of Nanobiotechnology 2018 16:3

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    The original article was published in Journal of Nanobiotechnology 2014 12:21

  32. Content type: Research

    Treatment of severe or chronic skin wounds is an important challenge facing medicine and a significant health care burden. Proper wound healing is often affected by bacterial infection; where biofilm formation...

    Authors: Mario Alberto Pérez-Díaz, Phaedra Silva-Bermudez, Binisa Jiménez-López, Valentín Martínez-López, Yaaziel Melgarejo-Ramírez, Ana Brena-Molina, Clemente Ibarra, Isabel Baeza, M. Esther Martínez-Pardo, M. Lourdes Reyes-Frías, Erik Márquez-Gutiérrez, Cristina Velasquillo, Gabriel Martínez-Castañon, Fidel Martinez-Gutierrez and Roberto Sánchez-Sánchez

    Citation: Journal of Nanobiotechnology 2018 16:2

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  33. Content type: Research

    The results showed that the deciding factor is the culture medium in which the bacteria and the graphene oxide (GO) are incubated at the initial manipulation step. These findings allow better use of GO and GO-...

    Authors: Ping-Ching Wu, Hua-Han Chen, Shih-Yao Chen, Wen-Lung Wang, Kun-Lin Yang, Chia-Hung Huang, Hui-Fang Kao, Jui-Cheng Chang, Chih-Li Lilian Hsu, Jiu-Yao Wang, Ting-Mao Chou and Wen-Shuo Kuo

    Citation: Journal of Nanobiotechnology 2018 16:1

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  34. Content type: Research

    Selenium (Se) is an indispensable trace element required for animals and humans, and extra Se-supplement is necessary, especially for those having Se deficiency. Recently, selenium nanoparticles (SeNPs), as a ...

    Authors: Kaikai Bai, Bihong Hong, Zhuan Hong, Jipeng Sun and Changsen Wang

    Citation: Journal of Nanobiotechnology 2017 15:92

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  35. Content type: Research

    Since the anticancer drugs have diverse inhibited mechanisms to the cancer cells, the use of two or more kinds of anticancer agents may achieve excellent therapeutic effects, especially to the drug-resistant t...

    Authors: Xiangrui Yang, Shichao Wu, Wanyi Xie, Anran Cheng, Lichao Yang, Zhenqing Hou and Xin Jin

    Citation: Journal of Nanobiotechnology 2017 15:91

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  36. Content type: Research

    The insufficient understanding of unintended biological impacts from nanomaterials (NMs) represents a serious impediment to their use for scientific, technological, and medical applications. While previous stu...

    Authors: Sheenah L. Bryant, Josh E. Eixenberger, Steven Rossland, Holly Apsley, Connor Hoffmann, Nisha Shrestha, Michael McHugh, Alex Punnoose and Daniel Fologea

    Citation: Journal of Nanobiotechnology 2017 15:90

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  37. Content type: Research

    Secondary caries are considered the main cause of dental restoration failure. In this context, anti-biofilm and bactericidal properties are desired in dental materials against pathogens such as Streptococcus muta...

    Authors: Agnese Bregnocchi, Elena Zanni, Daniela Uccelletti, Fabrizio Marra, Domenico Cavallini, Francesca De Angelis, Giovanni De Bellis, Maurizio Bossù, Gaetano Ierardo, Antonella Polimeni and Maria Sabrina Sarto

    Citation: Journal of Nanobiotechnology 2017 15:89

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  38. Content type: Research

    This work aimed to provide useful information on the use of nanoemulsions for the percutaneous administration of triptolide. Lipid nanosystems have great potential for transdermal drug delivery. Nanoemulsions ...

    Authors: Meng Yang, Yongwei Gu, Dishun Yang, Xiaomeng Tang and Jiyong Liu

    Citation: Journal of Nanobiotechnology 2017 15:88

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  39. Content type: Research

    Chemotherapeutic drugs used for cancer therapy frequently encounter multiple-drug resistance (MDR). Nanoscale carriers that can target tumors to accumulate and release drugs intracellularly have the greatest p...

    Authors: Yi Zhou, Huaying Wen, Liang Gu, Jijun Fu, Jiayi Guo, Lingran Du, Xiaoqin Zhou, Xiyong Yu, Yugang Huang and He Wang

    Citation: Journal of Nanobiotechnology 2017 15:87

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  40. Content type: Research

    Targeted superparamagnetic iron oxide (SPIO) nanoparticles have emerged as a promising biomarker detection tool for molecular magnetic resonance (MR) image diagnosis. To identify patients who could benefit fro...

    Authors: Huai-Lu Chen, Fei-Ting Hsu, Yu-Chieh Jill Kao, Hua-Shan Liu, Wan-Zhen Huang, Chia-Feng Lu, Ping-Huei Tsai, Ahmed Atef Ahmed Ali, Gilbert Aaron Lee, Ray-Jade Chen and Cheng-Yu Chen

    Citation: Journal of Nanobiotechnology 2017 15:86

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  41. Content type: Research

    Anti-angiogenic therapy has great potential for cancer therapy with several FDA approved formulations but there are considerable side effects upon the normal blood vessels that decrease the potential applicati...

    Authors: Pedro Pedrosa, Amelie Heuer-Jungemann, Antonios G. Kanaras, Alexandra R. Fernandes and Pedro V. Baptista

    Citation: Journal of Nanobiotechnology 2017 15:85

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  42. Content type: Research

    The cell source for transplantation therapy is always a prerequisite question to be solved in clinical applications. Neural cells are considered non-regenerable, which highly restrict their application in the ...

    Authors: Qingtong Yu, Jingjing Chen, Wenwen Deng, Xia Cao, Yan Wang, Jie Zhou, Wenqian Xu, Pan Du, Qiang Wang, Jiangnan Yu and Ximing Xu

    Citation: Journal of Nanobiotechnology 2017 15:82

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  43. Content type: Review

    Aptamers are short non-coding, single-stranded oligonucleotides (RNA or DNA) developed through Systematic Evolution of Ligands by Exponential enrichment (SELEX) in vitro. Similar to antibodies, aptamers can bi...

    Authors: Mei Liu, Xiaocheng Yu, Zhu Chen, Tong Yang, Dandan Yang, Qianqian Liu, Keke Du, Bo Li, Zhifei Wang, Song Li, Yan Deng and Nongyue He

    Citation: Journal of Nanobiotechnology 2017 15:81

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  44. Content type: Research

    Increasing evidences indicate that exposure to multi-walled carbon nanotubes (MWCNTs) could induce adverse vascular effects, but the role of length of MWCNTs in determining the toxic effects is less studied. T...

    Authors: Jimin Long, Yafang Xiao, Liangliang Liu and Yi Cao

    Citation: Journal of Nanobiotechnology 2017 15:80

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  45. Content type: Research

    When evaluating the toxicity of engineered nanomaterials (ENMS) it is important to use multiple bioassays based on different mechanisms of action. In this regard we evaluated the use of gene expression and com...

    Authors: Donald H. Atha, Amber Nagy, Andrea Steinbrück, Allison M. Dennis, Jennifer A. Hollingsworth, Varsha Dua, Rashi Iyer and Bryant C. Nelson

    Citation: Journal of Nanobiotechnology 2017 15:79

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