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  1. Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays ...

    Authors: Hossein Kamali, Shiva Golmohammadzadeh, Hamed Zare, Rahim Nosrati, Mohammad Fereidouni and Hossein Safarpour
    Citation: Journal of Nanobiotechnology 2022 20:438
  2. Photodynamic therapy (PDT), and sonodynamic therapy (SDT) that developed from PDT, have been studied for decades to treat solid tumors. Compared with other deep tumors, the accessibility of urological tumors (...

    Authors: Xiao Hu, Yu-Sen Zhang, Yi-Chao Liu, Na Wang, Xian-Tao Zeng and Ling-Ling Zhang
    Citation: Journal of Nanobiotechnology 2022 20:437
  3. Nanomedicine has emerged as a promising strategy for cancer treatment. The most representative nanomedicine used in clinic is PEGylated liposomal doxorubicin DOXIL®, which is first FDA-approved nanomedicine. Howe...

    Authors: Man Kyu Shim, Suah Yang, Jooho Park, Jun Sik Yoon, Jinseong Kim, Yujeong Moon, Nayeon Shim, Mihee Jo, Yongwhan Choi and Kwangmeyung Kim
    Citation: Journal of Nanobiotechnology 2022 20:436
  4. Exosomes of human cardiosphere-derived cells (CDCs) are very promising for treating cardiovascular disorders. However, the current challenge is inconvenient delivery methods of exosomes for clinical applicatio...

    Authors: Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li and Yan Wang
    Citation: Journal of Nanobiotechnology 2022 20:435
  5. Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoin...

    Authors: Linjun Yang, Congcong Yu, Xuhui Fan, Tianni Zeng, Wentao Yang, Jiechao Xia, Jianle Wang, Litao Yao, Chuan Hu, Yang Jin, Yutao Zhu, Jiaxin Chen and Zhijun Hu
    Citation: Journal of Nanobiotechnology 2022 20:433
  6. Effective therapeutics to stop or reverse liver fibrosis have not emerged, because these potential agents cannot specifically target activated hepatic stellate cells (aHSCs) or are frequently toxic to parenchy...

    Authors: Yan Lin, Mengchao Yan, Zhongtian Bai, Ye Xie, Longfei Ren, Jiayun Wei, Dan Zhu, Haiping Wang, Yonggang Liu, Junqian Luo and Xun Li
    Citation: Journal of Nanobiotechnology 2022 20:432
  7. Precision medicine has put forward the proposition of "precision targeting" for modern drug delivery systems. Inspired by techniques from biology, pharmaceutical sciences, and nanoengineering, numerous targete...

    Authors: Haoyue Song, Xiaohang Chen, Yujia Hao, Jia Wang, Qingpeng Xie and Xing Wang
    Citation: Journal of Nanobiotechnology 2022 20:431
  8. The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision ther...

    Authors: Yanquan Fei, Yong Ma, Huaizu Zhang, Hao Li, Guangfu Feng and Jun Fang
    Citation: Journal of Nanobiotechnology 2022 20:430
  9. Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a c...

    Authors: Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang and Wentao Li
    Citation: Journal of Nanobiotechnology 2022 20:429
  10. Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was ...

    Authors: Kwang-Soo Kim, Bongseo Choi, Hyunjun Choi, Min Jun Ko, Dong-Hwan Kim and Dong-Hyun Kim
    Citation: Journal of Nanobiotechnology 2022 20:428
  11. Primary liver cancer has become the second most fatal cancer in the world, and its five-year survival rate is only 10%. Most patients are in the middle and advanced stages at the time of diagnosis, losing the ...

    Authors: Mengjiao Xu, Liu Yang, Yanjie Lin, Yao Lu, Xiaoyue Bi, Tingting Jiang, Wen Deng, Lu Zhang, Wei Yi, Yao Xie and Minghui Li
    Citation: Journal of Nanobiotechnology 2022 20:427
  12. Skin tissue is vital in protecting the body from injuries and bacterial infections. Wound infection caused by bacterial colonization is one of the main factors hindering wound healing. Wound infection caused b...

    Authors: Yapeng Lu, Meihui Zhao, Ye Peng, Sizhe He, Xiaopeng Zhu, Chao Hu, Guanghua Xia, Tao Zuo, Xueying Zhang, Yonghuan Yun, Weimin Zhang and Xuanri Shen
    Citation: Journal of Nanobiotechnology 2022 20:426
  13. Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy in the clinic. The discovery of over-expressed components on the tumor cell surface and their specific ligands prov...

    Authors: Bing Zhang, Ying Zhang, Wenli Dang, Bin Xing, Changxiang Yu, Pan Guo, Jiaxin Pi, Xiuping Deng, Dongli Qi and Zhidong Liu
    Citation: Journal of Nanobiotechnology 2022 20:425
  14. Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type o...

    Authors: Tao Jia, Dan Li, Jiarui Du, Xikui Fang, Valeriy Gerasimov, Hans Ågren and Guanying Chen
    Citation: Journal of Nanobiotechnology 2022 20:424
  15. Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but...

    Authors: Zekun Shen, Weiyi Wang, Jinxing Chen, Bingyi Chen, Yanan Tang, Jiaxuan Hou, Jiayan Li, Shuang Liu, Yifan Mei, Liwei Zhang and Shaoying Lu
    Citation: Journal of Nanobiotechnology 2022 20:422
  16. Light-mediated nanotherapeutics have recently emerged as promising strategies to precisely control the activation of therapeutic reagents and imaging probe both in vitro and in vivo, largely ascribed to their ...

    Authors: Dan Zhao, Wang Zhang, Shuang Yu, Si-Lei Xia, Ya-Nan Liu and Guan-Jun Yang
    Citation: Journal of Nanobiotechnology 2022 20:421
  17. Intervertebral disc degeneration (IDD) is the pathological reason of back pain and the therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived small extracellular vesicles (EVs...

    Authors: Zhiwei Liao, Wencan Ke, Hui Liu, Bide Tong, Kun Wang, Xiaobo Feng, Wenbin Hua, Bingjin Wang, Yu Song, Rongjin Luo, Huaizhen Liang, Weifeng Zhang, Kangcheng Zhao, Shuai Li and Cao Yang
    Citation: Journal of Nanobiotechnology 2022 20:420
  18. Targeting cartilage is a promising strategy for the treatment of osteoarthritis, and various delivery vehicles were developed to assist the therapeutic agents into cartilage. However, the underlying biomechani...

    Authors: Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan and Hengfeng Yuan
    Citation: Journal of Nanobiotechnology 2022 20:419
  19. The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involv...

    Authors: Matteo Chighizola, Tania Dini, Stefania Marcotti, Mirko D’Urso, Claudio Piazzoni, Francesca Borghi, Anita Previdi, Laura Ceriani, Claudia Folliero, Brian Stramer, Cristina Lenardi, Paolo Milani, Alessandro Podestà and Carsten Schulte
    Citation: Journal of Nanobiotechnology 2022 20:418
  20. While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One o...

    Authors: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio…
    Citation: Journal of Nanobiotechnology 2022 20:417
  21. Drug resistance of pathogens and immunosuppression are the main causes of clinical stagnation of osteomyelitis. The ideal treatment strategy for osteomyelitis is to achieve both efficient antibacterial and bon...

    Authors: Xiaoting Xie, Jiemao Wei, Bin Zhang, Wei Xiong, Zhiyi He, Yayun Zhang, Chenghao Gao, Yuandi Zhao and Bo Liu
    Citation: Journal of Nanobiotechnology 2022 20:416
  22. Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that seriously threatens human health. Due to the unique organ structure of the gastrointestinal tract, endoscopic and MRI dia...

    Authors: Shenghe Deng, Junnan Gu, Zhenxing Jiang, Yinghao Cao, Fuwei Mao, Yifan Xue, Jun Wang, Kun Dai, Le Qin, Ke Liu, Ke Wu, Qianyuan He and Kailin Cai
    Citation: Journal of Nanobiotechnology 2022 20:415
  23. The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration...

    Authors: Jiaxuan Xia, Shuya Zhang, Ru Zhang, Anni Wang, Ying Zhu, Meichen Dong, Shaojie Ma, Chao Hong, Shengyao Liu, Dan Wang and Jianxin Wang
    Citation: Journal of Nanobiotechnology 2022 20:414
  24. Parkinson’s disease (PD) significantly affects patients’ quality of life and represents a high economic burden for health systems. Given the lack of safe and effective treatments for PD, drug repositioning see...

    Authors: Héctor Hernández-Parra, Hernán Cortés, José Arturo Avalos-Fuentes, María Del Prado-Audelo, Benjamín Florán, Gerardo Leyva-Gómez, Javad Sharifi-Rad and William C. Cho
    Citation: Journal of Nanobiotechnology 2022 20:413
  25. Besides the broad development of nanotechnological approaches for cancer diagnosis and therapy, currently, there is no significant progress in the treatment of different types of brain tumors. Therapeutic mole...

    Authors: Ksenia Mitusova, Oleksii O. Peltek, Timofey E. Karpov, Albert R. Muslimov, Mikhail V. Zyuzin and Alexander S. Timin
    Citation: Journal of Nanobiotechnology 2022 20:412
  26. The major challenge to controlling the COVID pandemic is the rapid mutation rate of the SARS-CoV-2 virus, leading to the escape of the protection of vaccines and most of the neutralizing antibodies to date. Th...

    Authors: Dongping Zhao, Liqin Liu, Xinlin Liu, Jinlei Zhang, Yuqing Yin, Linli Luan, Dingwen Jiang, Xiong Yang, Lei Li, Hualong Xiong, Dongming Xing, Qingbing Zheng, Ningshao Xia, Yuyong Tao, Shaowei Li and Haiming Huang
    Citation: Journal of Nanobiotechnology 2022 20:411
  27. Photodynamic therapy (PDT) has emerged as a promising tumor treatment method via light-triggered generation of reactive oxygen species (ROS) to kill tumor cells. However, the efficacy of PDT is usually restric...

    Authors: Xiaoxiong Xiao, Min Chen, Yuchen Zhang, Liang Li, Ying Peng, Junyu Li and Wenhu Zhou
    Citation: Journal of Nanobiotechnology 2022 20:410

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:508

  28. Radiation-induced skin injury (RISI) is an important challenge for clinical treatments. The main causes of RISI include hypoxia in the wound microenvironment, reactive oxygen species (ROS) activation, and down...

    Authors: Daijun Zhou, Min Du, Han Luo, Fengwei Ran, Xiang Zhao, Yan Dong, Tao Zhang, Jie Hao, Dong Li and Jianjun Li
    Citation: Journal of Nanobiotechnology 2022 20:409
  29. Nanofabrication technologies have been recently applied to the development of engineered nano–bio interfaces for manipulating complex cellular processes. In particular, vertically configurated nanostructures s...

    Authors: Yaping Chen, Hao Zhe Yoh, Ali-Reza Shokouhi, Takahide Murayama, Koukou Suu, Yasuhiro Morikawa, Nicolas H. Voelcker and Roey Elnathan
    Citation: Journal of Nanobiotechnology 2022 20:406
  30. Septic heart failure accounts for high mortality rates globally. With a strong reducing capacity, zero-valent iron nanoparticles (nanoFe) have been applied in many fields. However, the precise roles and mechan...

    Authors: Daquan Wang, Changyu Wang, Zhenxing Liang, Wangrui Lei, Chao Deng, Xiaoli Liu, Shuai Jiang, Yanli Zhu, Shaofei Zhang, Wenwen Yang, Ying Chen, Yao Qiu, Lingjie Meng and Yang Yang
    Citation: Journal of Nanobiotechnology 2022 20:405
  31. Ulcerative colitis (UC) is a major type of inflammatory bowel disease (IBD), which could induce bloody stool, diarrhea, colon atrophy and eventually lead to colorectal cancer. The conventional daily oral admin...

    Authors: Meng Gao, Chen Yang, Chenghu Wu, Yue Chen, Hongqin Zhuang, Jilong Wang and Zhiting Cao
    Citation: Journal of Nanobiotechnology 2022 20:404
  32. The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the t...

    Authors: Huali Ye, Xin Hu, Yang Wen, Chongqi Tu, Francis Hornicek, Zhenfeng Duan and Li Min
    Citation: Journal of Nanobiotechnology 2022 20:403
  33. 7-p-trifluoromethylphenyl-FL118 (FLQY2) is a camptothecin analog with excellent antitumor efficacy against various solid tumors. However, its poor solubility and low bioavailability limited the development of ...

    Authors: Yi Wang, Wenchao Wang, Endian Yu, Wenya Zhuang, Xuanrong Sun, Hong Wang and Qingyong Li
    Citation: Journal of Nanobiotechnology 2022 20:402
  34. Cancer cell membrane-camouflaged nanotechnology for metal complex can enhance its biocompatibility and extend the effective circulation time in body. The ruthenium polypyridyl complex (RuPOP) has extensive ant...

    Authors: Xiaoying Li, Yanzi Yu, Qi Chen, Jiabao Lin, Xueqiong Zhu, Xiaoting Liu, Lizhen He, Tianfeng Chen and Weiling He
    Citation: Journal of Nanobiotechnology 2022 20:401
  35. Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are...

    Authors: Abdurhaman Teyib Abafogi, Tepeng Wu, Daekyu Lee, Jinyeop Lee, Gyoujin Cho, Luke P. Lee and Sungsu Park
    Citation: Journal of Nanobiotechnology 2022 20:400
  36. Effective therapeutics and vaccines for coronavirus disease 2019 (COVID-19) are currently lacking because of the mutation and immune escape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Base...

    Authors: Xiaoli Wu, Junye Liu, Hongpeng Zhang, Hua Zhou, Wen Wang, Yuanyan Ma, Shimei Shen, Xuefei Cai, Ailong Huang and Deqiang Wang
    Citation: Journal of Nanobiotechnology 2022 20:399
  37. The ideal neural interface or scaffold for stem cell therapy shall have good biocompatibility promoting survival, maturation and integration of neural stem cells (NSCs) in targeted brain regions. The unique el...

    Authors: Yige Li, Yangnan Hu, Hao Wei, Wei Cao, Yanru Qi, Shan Zhou, Panpan Zhang, Huawei Li, Geng-Lin Li and Renjie Chai
    Citation: Journal of Nanobiotechnology 2022 20:398
  38. Ischemic stroke is one of the most serious global public health problems. However, the performance of current therapeutic regimens is limited due to their poor target specificity, narrow therapeutic time windo...

    Authors: Ranran Duan, Ke Sun, Fang Fang, Ning Wang, Ruya He, Yang Gao, Lijun Jing, Yanfei Li, Zhe Gong, Yaobing Yao, Tingting Luan, Chaopeng Zhang, Jinwei Zhang, Yi Zhao, Haojie Xie, Yongyan Zhou…
    Citation: Journal of Nanobiotechnology 2022 20:397
  39. The abnormal expression of long non-coding RNAs (LncRNAs) in platelet-derived microparticles (PMPs) is closely related to immune disorders and may lead to antiphospholipid antibody syndrome and recurrent misca...

    Authors: Zhiwei Sun, Qian Zhou, Yufei Yang, Lei Li, Mengru Yu, Hui Li, Aihua Li, Xietong Wang and Yanyan Jiang
    Citation: Journal of Nanobiotechnology 2022 20:396
  40. The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel solutions potentially capable of revolutionizing health care by improving efficacy, bioavailability, drug targeting, and saf...

    Authors: Saquib Waheed, Zhibin Li, Fangyingnan Zhang, Anna Chiarini, Ubaldo Armato and Jun Wu
    Citation: Journal of Nanobiotechnology 2022 20:395
  41. Epithelial-mesenchymal transition (EMT), a differentiation process with aberrant changes of tumor cells, is identified as an initial and vital procedure for metastatic processes. Inflammation is a significant ...

    Authors: Tianze Jiang, Laozhi Xie, Songlei Zhou, Yipu Liu, Yukun Huang, Ni Mei, Fenfen Ma, Jingru Gong, Xiaoling Gao and Jun Chen
    Citation: Journal of Nanobiotechnology 2022 20:394
  42. High-quality point-of-care is critical for timely decision of disease diagnosis and healthcare management. In this regard, biosensors have revolutionized the field of rapid testing and screening, however, are ...

    Authors: Sabyasachi Dash, Tuhin Das, Paritosh Patel, Pritam Kumar Panda, Mrutyunjay Suar and Suresh K. Verma
    Citation: Journal of Nanobiotechnology 2022 20:393
  43. Injuries to the urethra can be caused by malformations, trauma, inflammation, or carcinoma, and reconstruction of the injured urethra is still a significant challenge in clinical urology. Implanting grafts for...

    Authors: Qinyuan Tan, Hanxiang Le, Chao Tang, Ming Zhang, Weijie Yang, Yazhao Hong and Xiaoqing Wang
    Citation: Journal of Nanobiotechnology 2022 20:392
  44. Cancer nanomedicines based on synthetic polypeptides have attracted much attention due to their superior biocompatibility and biodegradability, stimuli responsive capability through secondary conformation chan...

    Authors: Maliheh Hasannia, Khalil Abnous, Seyed Mohammad Taghdisi, Sirous Nekooei, Mohammad Ramezani and Mona Alibolandi
    Citation: Journal of Nanobiotechnology 2022 20:391
  45. Abundant glutathione (GSH) is a biological characteristic of lots of tumor cells. A growing number of studies are utilizing GSH depletion as an effective adjuvant therapy for tumor. However, due to the compens...

    Authors: Yang Gao, Yun Li, Hongmei Cao, Haixue Jia, Dianyu Wang, Chunhua Ren, Zhongyan Wang, Cuihong Yang and Jianfeng Liu
    Citation: Journal of Nanobiotechnology 2022 20:390
  46. Dysregulated mucosal immune responses and colonic fibrosis impose two formidable challenges for ulcerative colitis treatment. It indicates that monotherapy could not sufficiently deal with this complicated dis...

    Authors: Jiaxin Zhang, Ante Ou, Xueping Tang, Rong Wang, Yujuan Fan, Yuefei Fang, Yuge Zhao, Pengfei Zhao, Dongying Chen, Bing Wang and Yongzhuo Huang
    Citation: Journal of Nanobiotechnology 2022 20:389
  47. The anticancer treatment is largely affected by the microenvironment of the tumors, which not only resists the tumors to the thermo/chemo-therapy, but also promotes their growth and invasion. In this work, the...

    Authors: Ying Zhang, Jingyao Zhu, Zheng Zhang, Dannong He, Jun Zhu, Yunsheng Chen and Yixin Zhang
    Citation: Journal of Nanobiotechnology 2022 20:388

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