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  1. Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is hampered by the blood–brain barrier which limits the entry into the brain of most drugs from the blood. To bypass this barrier, con...

    Authors: Minghan Shi, Malathi Anantha, Mohamed Wehbe, Marcel B. Bally, David Fortin, Laurent-Olivier Roy, Gabriel Charest, Maxime Richer, Benoit Paquette and Léon Sanche

    Citation: Journal of Nanobiotechnology 2018 16:77

    Content type: Research

    Published on:

  2. Graphene’s unique physical structure, as well as its chemical and electrical properties, make it ideal for use in sensor technologies. In the past years, novel sensing platforms have been proposed with pristin...

    Authors: Janire Peña-Bahamonde, Hang N. Nguyen, Sofia K. Fanourakis and Debora F. Rodrigues

    Citation: Journal of Nanobiotechnology 2018 16:75

    Content type: Review

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  3. With the improvement of nanotechnology and nanomaterials, redox-responsive delivery systems have been studied extensively in some critical areas, especially in the field of biomedicine. The system constructed...

    Authors: Xiaoshuang Guo, Yuan Cheng, Xiaotian Zhao, Yanli Luo, Jianjun Chen and Wei-En Yuan

    Citation: Journal of Nanobiotechnology 2018 16:74

    Content type: Review

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  4. Galectin-3 (Gal-3) is a promising target in cancer therapy with a high therapeutic potential due to its abundant localization within the tumor tissue and its involvement in tumor development and proliferation....

    Authors: P. Bojarová, M. R. Tavares, D. Laaf, L. Bumba, L. Petrásková, R. Konefał, M. Bláhová, H. Pelantová, L. Elling, T. Etrych, P. Chytil and V. Křen

    Citation: Journal of Nanobiotechnology 2018 16:73

    Content type: Research

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  5. Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and...

    Authors: Hanzey Yasar, Alexander Biehl, Chiara De Rossi, Marcus Koch, Xabi Murgia, Brigitta Loretz and Claus-Michael Lehr

    Citation: Journal of Nanobiotechnology 2018 16:72

    Content type: Research

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  6. Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic ag...

    Authors: Jayanta Kumar Patra, Gitishree Das, Leonardo Fernandes Fraceto, Estefania Vangelie Ramos Campos, Maria del Pilar Rodriguez-Torres, Laura Susana Acosta-Torres, Luis Armando Diaz-Torres, Renato Grillo, Mallappa Kumara Swamy, Shivesh Sharma, Solomon Habtemariam and Han-Seung Shin

    Citation: Journal of Nanobiotechnology 2018 16:71

    Content type: Review

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  7. Upon ingestion, nanoparticles can interact with the intestinal epithelial barrier potentially resulting in systemic uptake of nanoparticles. Nanoparticle properties have been described to influence the protein...

    Authors: Ashraf Abdelkhaliq, Meike van der Zande, Ans Punt, Richard Helsdingen, Sjef Boeren, Jacques J. M. Vervoort, Ivonne M. C. M. Rietjens and Hans Bouwmeester

    Citation: Journal of Nanobiotechnology 2018 16:70

    Content type: Research

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  8. Porphyromonas gingivalis adherence to oral streptococci is a key point in the pathogenesis of periodontal diseases (Honda in Cell Host Microbe 10:423–425, 2011). Previous work in our groups has shown that a regio...

    Authors: Mohamed Y. Mahmoud, Donald R. Demuth and Jill M. Steinbach-Rankins

    Citation: Journal of Nanobiotechnology 2018 16:69

    Content type: Research

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  9. In recent years, nanoparticles (NPs) including nanostructured lipid carries (NLC) and solid lipid nanoparticles (SLN) captured an increasing amount of attention in the field of transdermal drug delivery system...

    Authors: Yongwei Gu, Meng Yang, Xiaomeng Tang, Ting Wang, Dishun Yang, Guangxi Zhai and Jiyong Liu

    Citation: Journal of Nanobiotechnology 2018 16:68

    Content type: Research

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  10. Intracellular protein and proteomic studies using mass spectrometry, imaging microscopy, flow cytometry, or western blotting techniques require genetic manipulation, cell permeabilization, and/or cell lysis. W...

    Authors: Elaheh Shekaramiz, Rupak Doshi and H. Kumar Wickramasinghe

    Citation: Journal of Nanobiotechnology 2018 16:67

    Content type: Short Communication

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  11. Although assemblies of hydrophobic-modified bacitracin A with PLGA (Nano-BAPLGA) have demonstrated promising antibacterial activities against both Gram-positive and Gram-negative bacteria, the desirable antibacte...

    Authors: Wei Hong, Lipeng Liu, Yining Zhao, Yinghui Liu, Dexian Zhang and Mingchun Liu

    Citation: Journal of Nanobiotechnology 2018 16:66

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2019 17:36

  12. Due to the high transfer ability of cancer cell, cancer has been regarded as a world-wide high mortality disease. Quantitative analysis of circulating tumor cells (CTCs) can provide some valuable clinical info...

    Authors: Xuan Wu, Tingyu Xiao, Zhang Luo, Rongxiang He, Yiping Cao, Zhenzhong Guo, Weiying Zhang and Yong Chen

    Citation: Journal of Nanobiotechnology 2018 16:65

    Content type: Research

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  13. Non-alcoholic fatty liver disease (NAFLD) is a chronic disease that causes excessive hepatic lipid accumulation. Reducing hepatic lipid deposition is a key issue in treatment and inhibition of NAFLD evolution....

    Authors: Jun Liang, Ying Liu, Jinguang Liu, Zhe Li, Qiangyuan Fan, Zifei Jiang, Fei Yan, Zhi Wang, Peiwen Huang and Nianping Feng

    Citation: Journal of Nanobiotechnology 2018 16:64

    Content type: Research

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  14. Epidermal growth factor (EGF) can promote cell proliferation as well as migration, which is feasible in tissue wound healing. Oil bodies have been exploited as an important platform to produce exogenous protei...

    Authors: Weidong Qiang, Tingting Zhou, Xinxin Lan, Xiaomei Zhang, Yongxin Guo, Muhammad Noman, Linna Du, Jie Zheng, Wenqing Li, Haoyang Li, Yubin Lu, Hongyu Wang, Lili Guan, Linbo Zhang, Xiaokun Li, Jing Yang…

    Citation: Journal of Nanobiotechnology 2018 16:62

    Content type: Research

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  15. Extracellular vesicles (EVs) and exosomes are nano-sized, membrane-bound vesicles shed by most eukaryotic cells studied to date. EVs play key signaling roles in cellular development, cancer metastasis, immune ...

    Authors: Travis J. Antes, Ryan C. Middleton, Kristin M. Luther, Takeshi Ijichi, Kiel A. Peck, Weixin Jane Liu, Jackie Valle, Antonio K. Echavez and Eduardo Marbán

    Citation: Journal of Nanobiotechnology 2018 16:61

    Content type: Research

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  16. Stable and non-toxic fluorescent markers are gaining attention in molecular diagnostics as powerful tools for enabling long and reliable biological studies. Such markers should not only have a long half-life u...

    Authors: Francisco Morales-Zavala, Nathalie Casanova-Morales, Raúl B. Gonzalez, América Chandía-Cristi, Lisbell D. Estrada, Ignacio Alvizú, Victor Waselowski, Fanny Guzman, Simón Guerrero, Marisol Oyarzún-Olave, Cristian Rebolledo, Enrique Rodriguez, Julien Armijo, Heman Bhuyan, Mario Favre, Alejandra R. Alvarez…

    Citation: Journal of Nanobiotechnology 2018 16:60

    Content type: Research

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  17. Various nanocarriers have been used to deliver subunit vaccines specifically to dendritic cells (DCs) for the improvement of immunogenicity. However, due to their insufficient DC priming ability, these vaccine...

    Authors: Hidenori Matsuo, Masaharu Somiya, Masumi Iijima, Takeshi Arakawa and Shun’ichi Kuroda

    Citation: Journal of Nanobiotechnology 2018 16:59

    Content type: Research

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  18. The transcription factor NF-kB plays an important role in the pathogenesis of rheumatoid arthritis (RA). Effective treatment of RA is hindered due to the lack of specificity of small molecules in the inflamed ...

    Authors: Weifeng Duan and Huan Li

    Citation: Journal of Nanobiotechnology 2018 16:58

    Content type: Research

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  19. Matrix-metalloproteinases, which are overexpressed in many types of cancer, can be applied to improve the bioavailability of chemotherapeutic drugs and guide therapeutic targeting. Thus, we aimed to develop en...

    Authors: Fangyuan Guo, Jiangqing Wu, Wenchao Wu, Dongxue Huang, Qinying Yan, Qingliang Yang, Ying Gao and Gensheng Yang

    Citation: Journal of Nanobiotechnology 2018 16:57

    Content type: Research

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  20. Chemotherapeutic agents (anti-cancer drugs) are small cytostatic or cytotoxic molecules that often bind to double-stranded DNA (dsDNA) resulting in modifications of their structural and nanomechanical properti...

    Authors: Dennis Kreft, Ying Wang, Michael Rattay, Katja Toensing and Dario Anselmetti

    Citation: Journal of Nanobiotechnology 2018 16:56

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2019 17:28

  21. Autophagy regulation through exogenous materials has aroused intensive attention to develop treatment protocols according to diverse human diseases. However, to the best of our knowledge, few examples have bee...

    Authors: Long Yuan, Fan Zhang, Xiaowei Qi, Yongjun Yang, Chang Yan, Jun Jiang and Jun Deng

    Citation: Journal of Nanobiotechnology 2018 16:55

    Content type: Research

    Published on:

  22. Tumor metastasis is the primary cause of mortality in cancer patients. Migratory breast cancer cells in lymphatic and blood vessels seek new sites and form metastatic colonies in the lung and bone, and then th...

    Authors: Yanxia Qin, Kui Chen, Weihong Gu, Xinghua Dong, Ruihong Lei, Yanan Chang, Xue Bai, Shibo Xia, Li Zeng, Jiaxin Zhang, Sihan Ma, Juan Li, Shan Li and Gengmei Xing

    Citation: Journal of Nanobiotechnology 2018 16:54

    Content type: Research

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  23. Titanium dioxide (TiO2) particles are commonly used as a food additive (E171 in the EU) for its whitening and opacifying properties. However, the risk of gut barrier disruption is an increasing concern because of...

    Authors: Pauline Talbot, Joanna M. Radziwill-Bienkowska, Jasper B. J. Kamphuis, Karine Steenkeste, Sarah Bettini, Véronique Robert, Marie-Louise Noordine, Camille Mayeur, Eric Gaultier, Philippe Langella, Catherine Robbe-Masselot, Eric Houdeau, Muriel Thomas and Muriel Mercier-Bonin

    Citation: Journal of Nanobiotechnology 2018 16:53

    Content type: Research

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  24. Nanoparticles have become one of the most promising among the potential materials used for biomedical applications. However, few researchers have focused on their effects on analgesia. Despite the fact that va...

    Authors: Ping-Ching Wu, Dar-Bin Shieh, Hung-Tsung Hsiao, Jeffery Chi-Fei Wang, Ya-Chi Lin and Yen-Chin Liu

    Citation: Journal of Nanobiotechnology 2018 16:49

    Content type: Research

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  25. Nano-PCR is a recent tool that is used in viral diseases diagnosis. The technique depends on the fundamental effects of gold nanoparticles (AuNPs) and is considered a very effective and sensitive tool in the d...

    Authors: Mervat E. Hamdy, Michele Del Carlo, Hussein A. Hussein, Taher A. Salah, Ayman H. El-Deeb, Mohamed M. Emara, Guilia Pezzoni and Dario Compagnone

    Citation: Journal of Nanobiotechnology 2018 16:48

    Content type: Research

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  26. Tumour-derived exosomes can be released to serum and provide information on the features of the malignancy, however, in order to perform systematic studies in biological samples, faster diagnostic techniques a...

    Authors: Sheila López-Cobo, Carmen Campos-Silva, Amanda Moyano, Myriam Oliveira-Rodríguez, Annette Paschen, María Yáñez-Mó, María Carmen Blanco-López and Mar Valés-Gómez

    Citation: Journal of Nanobiotechnology 2018 16:47

    Content type: Research

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  27. As a promising candidate for artificial enzymes, catalytically active nanomaterials show several advantages over natural enzymes, such as controlled synthesis at low cost, tunability of catalytic activities, a...

    Authors: Lin Long, Jianbo Liu, Kaishun Lu, Tao Zhang, Yunqing Xie, Yinglu Ji and Xiaochun Wu

    Citation: Journal of Nanobiotechnology 2018 16:46

    Content type: Research

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    The Correction to this article has been published in Journal of Nanobiotechnology 2019 17:4

  28. So far, how the animals evade the environmental nanomaterials is still largely unclear. In this study, we employed in vivo assay system of Caenorhabditis elegans to investigate the aversive behavior of nematodes ...

    Authors: Guosheng Xiao, He Chen, Natalia Krasteva, Qizhan Liu and Dayong Wang

    Citation: Journal of Nanobiotechnology 2018 16:45

    Content type: Research

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  29. Single-walled carbon nanotubes (SWCNTs) have many potential applications in various fields. Especially, the unique physicochemical properties make them as the prime candidates for applications in biomedical fi...

    Authors: Song Zhu, Fei Luo, Jian Li, Bin Zhu and Gao-Xue Wang

    Citation: Journal of Nanobiotechnology 2018 16:44

    Content type: Research

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  30. Suitable fluorophores are the core of fluorescence imaging. Among the most exciting, yet controversial, labels are quantum dots (QDs) with their unique optical and chemical properties, but also considerable to...

    Authors: Hana Buchtelova, Vladislav Strmiska, Zuzana Skubalova, Simona Dostalova, Petr Michalek, Sona Krizkova, David Hynek, Lukas Kalina, Lukas Richtera, Amitava Moulick, Vojtech Adam and Zbynek Heger

    Citation: Journal of Nanobiotechnology 2018 16:43

    Content type: Research

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  31. Ag2S has the characteristics of conventional quantum dot such as broad excitation spectrum, narrow emission spectrum, long fluorescence lifetime, strong anti-bleaching ability, and other optical properties. Moreo...

    Authors: Xiao-Shuai Zhang, Yang Xuan, Xiao-Quan Yang, Kai Cheng, Ruo-Yun Zhang, Cheng Li, Fang Tan, Yuan-Cheng Cao, Xian-Lin Song, Jie An, Xiao-Lin Hou and Yuan-Di Zhao

    Citation: Journal of Nanobiotechnology 2018 16:42

    Content type: Research

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  32. Radioactive isotope-labeled gold nanomaterials have potential biomedical applications. Here, we report the synthesis and characterization of PEGylated crushed gold shell-radioactive iodide-124-labeled gold cor...

    Authors: Sang Bong Lee, Dinesh Kumar, Yinghua Li, In-Kyu Lee, Sung Jin Cho, Sang Kyoon Kim, Sang-Woo Lee, Shin Young Jeong, Jaetae Lee and Yong Hyun Jeon

    Citation: Journal of Nanobiotechnology 2018 16:41

    Content type: Research

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  33. Nanobiotechnology has the potential to revolutionize diverse sectors including medicine, agriculture, food, textile and pharmaceuticals. Disease diagnostics, therapeutics and crop protection strategies are fas...

    Authors: Vrantika Chaudhary, Sumit Jangra and Neelam R. Yadav

    Citation: Journal of Nanobiotechnology 2018 16:40

    Content type: Review

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  34. Virus-like-particles (VLPs) are attractive nanoparticulate scaffolds for broad applications in material/biological sciences and medicine. Prior their functionalization, specific adaptations have to be carried ...

    Authors: Jens Schumacher, Tijana Bacic, René Staritzbichler, Matin Daneschdar, Thorsten Klamp, Philipp Arnold, Sabrina Jägle, Özlem Türeci, Jürgen Markl and Ugur Sahin

    Citation: Journal of Nanobiotechnology 2018 16:39

    Content type: Research

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  35. Multidrug resistance-associated protein 1 (MRP1) overexpression plays a major role in chemoresistance in glioblastoma multiforme (GBM) contributing to its notorious deadly nature. Although MRP1-siRNA transfect...

    Authors: Wing Yin Tong, Mohammed Alnakhli, Richa Bhardwaj, Sinoula Apostolou, Sougata Sinha, Cara Fraser, Tim Kuchel, Bryone Kuss and Nicolas H. Voelcker

    Citation: Journal of Nanobiotechnology 2018 16:38

    Content type: Research

    Published on:

  36. Short nucleic acid oligomers have found a wide range of applications in experimental physics, biology and medicine, and show potential for the treatment of acquired and genetic diseases. These applications rel...

    Authors: Donny de Bruin, Nelli Bossert, Annemieke Aartsma-Rus and Dirk Bouwmeester

    Citation: Journal of Nanobiotechnology 2018 16:37

    Content type: Research

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  37. Theranostic perfluorocarbon nanoprobes have recently attracted attention due to their fascinating versatility in integrating diagnostics and therapeutics into a single system. Furthermore, although 17β-estradi...

    Authors: Xueli Zhao, Wen Luo, Jing Hu, Lei Zuo, Jing Wang, Rui Hu, Bo Wang, Lei Xu, Jing Li, Meng Wu, Pan Li and Liwen Liu

    Citation: Journal of Nanobiotechnology 2018 16:36

    Content type: Research

    Published on:

  38. Cilomilast is a phosphodiesterase 4 (PDE4) inhibitor for treating inflammatory lung diseases. This agent has a narrow therapeutic index with significant adverse effects on the nervous system. This study was co...

    Authors: Fu-Chao Liu, Huang-Ping Yu, Cheng-Yu Lin, Ahmed O. Elzoghby, Tsong-Long Hwang and Jia-You Fang

    Citation: Journal of Nanobiotechnology 2018 16:35

    Content type: Research

    Published on:

  39. Peptide-drug-conjugates (PDCs) are being developed as an effective strategy to specifically deliver cytotoxic drugs to cancer cells. However one of the challenges to their successful application is the relativ...

    Authors: Kalishwaralal Kalimuthu, Bat-Chen Lubin, Andrii Bazylevich, Gary Gellerman, Ofer Shpilberg, Galia Luboshits and Michael A. Firer

    Citation: Journal of Nanobiotechnology 2018 16:34

    Content type: Research

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  40. Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as...

    Authors: Inmaculada Dalmau-Mena, Pablo del Pino, Beatriz Pelaz, Miguel Ángel Cuesta-Geijo, Inmaculada Galindo, María Moros, Jesús M. de la Fuente and Covadonga Alonso

    Citation: Journal of Nanobiotechnology 2018 16:33

    Content type: Research

    Published on:

  41. Memantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to ...

    Authors: Elena Sánchez-López, Miren Ettcheto, Maria Antonia Egea, Marta Espina, Amanda Cano, Ana Cristina Calpena, Antoni Camins, Nuria Carmona, Amélia M. Silva, Eliana B. Souto and Maria Luisa García

    Citation: Journal of Nanobiotechnology 2018 16:32

    Content type: Research

    Published on:

  42. Synthesis of silver nano-compounds with enhanced antimicrobial effects is of great interest for the development of new antibacterial agents. Previous studies have reported the antibacterial properties of pegyl...

    Authors: Seong B. Park, Christy S. Steadman, Atul A. Chaudhari, Shreekumar R. Pillai, Shree R. Singh, Peter L. Ryan, Scott T. Willard and Jean M. Feugang

    Citation: Journal of Nanobiotechnology 2018 16:31

    Content type: Research

    Published on:

  43. The rational design of theranostic nanoprobe to present responsive effect of therapeutic potency and enhanced diagnostic imaging in tumor milieu plays a vital role for efficient personalized cancer therapy and...

    Authors: Xi Huang, Yaping Yuan, Weiwei Ruan, Lianhua Liu, Maili Liu, Shizhen Chen and Xin Zhou

    Citation: Journal of Nanobiotechnology 2018 16:30

    Content type: Research

    Published on:

  44. Gene therapy has been developed and used in medical treatment for many years, especially for the enhancement of endothelialization and angiogenesis. But slow endosomal escape rate is still one of the major bar...

    Authors: Qian Li, Xuefang Hao, Syed Saqib Ali Zaidi, Jintang Guo, Xiangkui Ren, Changcan Shi, Wencheng Zhang and Yakai Feng

    Citation: Journal of Nanobiotechnology 2018 16:29

    Content type: Research

    Published on:

  45. The systemic administration of cytotoxic chemotherapeutic agents for cancer treatment often has toxic side effects, limiting the usage dose. To increase chemotherapeutic efficacy while reducing toxic effects, ...

    Authors: Ashraf Alemi, Javad Zavar Reza, Fateme Haghiralsadat, Hossein Zarei Jaliani, Mojtaba Haghi Karamallah, Seyed Ahmad Hosseini and Somayeh Haghi Karamallah

    Citation: Journal of Nanobiotechnology 2018 16:28

    Content type: Research

    Published on:

  46. Vascular homeostasis is ensured by a dynamic interplay involving the endothelium, the platelets and the coagulation system. Thus, the vascular safety of particulate materials must address this integrated syste...

    Authors: Catarina Santos, Suzy Turiel, Pedro Sousa Gomes, Elísio Costa, Alice Santos-Silva, Paulo Quadros, José Duarte, Sílvia Battistuzzo and Maria Helena Fernandes

    Citation: Journal of Nanobiotechnology 2018 16:27

    Content type: Research

    Published on:

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