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  1. The plant toxin ricin, especially its cytotoxic A chain (RTA), can be genetically engineered with targeting ligands to develop specific anti-cancer recombinant immunotoxins (RITs). Here, we used affibody molec...

    Authors: Seong Guk Park, Heeyeon Kim, Heejin Jun, Sun Young Choi, Eunhee Kim and Sebyung Kang
    Citation: Journal of Nanobiotechnology 2022 20:387
  2. The colonization of bacterial pathogens is a major concern in wound infection and becoming a public health issue. Herein, a core–shell structured Ag@MSN (silver core embedded with mesoporous silica, AM)-based ...

    Authors: Qiqi Liu, Ying Zhang, Jingkai Huang, Zhourui Xu, Xiang Li, Jingyu Yang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Jinbo Lin, Chengbin Yang, Jia Liu and Suxia Lin
    Citation: Journal of Nanobiotechnology 2022 20:386
  3. Exosomes are recognized as effective platforms for targeted delivery for their high physicochemical stability and biocompatibility. However, most of the exosomes are inevitably and rapidly cleared by mononucle...

    Authors: Zhuo Wan, Xueqi Gan, Ruiyan Mei, Jianbin Du, Wen Fan, Mengying Wei, Guodong Yang, Weiwei Qin, Zhuoli Zhu and Li Liu
    Citation: Journal of Nanobiotechnology 2022 20:385
  4. Melanoma is the most malignant skin tumor and is difficult to cure with the alternative treatments of chemotherapy, biotherapy, and immunotherapy. Our previous study showed that triptolide (TP) exhibited powerful...

    Authors: Yongwei Gu, Yue Du, Liangdi Jiang, Xiaomeng Tang, Aixue Li, Yunan Zhao, Yitian Lang, Xiaoyan Liu and Jiyong Liu
    Citation: Journal of Nanobiotechnology 2022 20:384
  5. Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to...

    Authors: Sheng Chen, Yonghong Song, Xu Yan, Liang Dong, Yunjun Xu, Shouhu Xuan, Quan Shu, Baoqiang Cao, Jinlong Hu, Hanye Xing, Wenshu Wu, Zhengbao Zha and Yang Lu
    Citation: Journal of Nanobiotechnology 2022 20:381
  6. Innate immunity is the first line of defense against invading pathogens. Innate immune cells can recognize invading pathogens through recognizing pathogen-associated molecular patterns (PAMPs) via pattern reco...

    Authors: Chung-Nga Ko, Shaohong Zang, Yingtang Zhou, Zhangfeng Zhong and Chao Yang
    Citation: Journal of Nanobiotechnology 2022 20:380
  7. Disruption of the postsynaptic density protein-95 (PSD95)—neuronal nitric oxide synthase (nNOS) coupling is an effective way to treat ischemic stroke, however, it still faces some challenges, especially lack o...

    Authors: Yingying Ding, Yang Jin, Tao Peng, Yankun Gao, Yang Zang, Hongliang He, Fei Li, Yu Zhang, Hongjuan Zhang and Lina Chen
    Citation: Journal of Nanobiotechnology 2022 20:379
  8. Low-intensity pulsed ultrasound (LIPUS) has been reported to accelerate fracture healing, but the mechanism is unclear and its efficacy needs to be further optimized. Ultrasound in combination with functionali...

    Authors: Huan Yao, Liang Zhang, Shujin Yan, Yiman He, Hui Zhu, Yasha Li, Dong Wang and Ke Yang
    Citation: Journal of Nanobiotechnology 2022 20:378
  9. Type 1 diabetes mellitus (T1DM) is an autoimmune disease mediated by autoreactive T cells and dominated by Th1 response polarization. Insulin replacement therapy faces great challenges to this autoimmune disea...

    Authors: Haoming Huang, Dian Hu, Zhuo Chen, Jiarong Xu, Rengui Xu, Yusheng Gong, Zhengming Fang, Ting Wang and Wei Chen
    Citation: Journal of Nanobiotechnology 2022 20:377
  10. Breast cancer is the leading cause of cancer-related deaths in women and remains a formidable therapeutic challenge. Mitochondria participate in a myriad of essential cellular processes, such as metabolism, an...

    Authors: Liwei Gu, Jiaxing Zhang, Dandan Liu, Jiayun Chen, Shuzhi Liu, Qing Peng, Ya Tian, Maobo Du, Junzhe Zhang, Wei Xiao, Shuo Shen and Jigang Wang
    Citation: Journal of Nanobiotechnology 2022 20:376
  11. Given the spasmodic increment in antimicrobial resistance (AMR), world is on the verge of “post-antibiotic era”. It is anticipated that current SARS-CoV2 pandemic would worsen the situation in future, mainly d...

    Authors: Nayanika Chakraborty, Diksha Jha, Indrajit Roy, Pradeep Kumar, Shailendra Singh Gaurav, Kalisvar Marimuthu, Oon-Tek Ng, Rajamani Lakshminarayanan, Navin Kumar Verma and Hemant K. Gautam
    Citation: Journal of Nanobiotechnology 2022 20:375
  12. Ovarian aging is characterized by a progressive decline in ovarian function. With the increase in life expectancy worldwide, ovarian aging has gradually become a key health problem among women. Over the years,...

    Authors: Meng Wu, Yican Guo, Simin Wei, Liru Xue, Weicheng Tang, Dan Chen, Jiaqiang Xiong, Yibao Huang, Fangfang Fu, Chuqing Wu, Ying Chen, Su Zhou, Jinjin Zhang, Yan Li, Wenwen Wang, Jun Dai…
    Citation: Journal of Nanobiotechnology 2022 20:374
  13. The escape of bladder cancer from immunosurveillance causes monotherapy to exhibit poor efficacy; therefore, designing a multifunctional nanoparticle that boosts programmed cell death and immunoactivation has ...

    Authors: Yu-Cheng Chin, Li-Xing Yang, Fei-Ting Hsu, Che-Wei Hsu, Te-Wei Chang, Hsi-Ying Chen, Linda Yen-Chien Chen, Zi Chun Chia, Chun-Hua Hung, Wu-Chou Su, Yi-Chun Chiu, Chih-Chia Huang and Mei-Yi Liao
    Citation: Journal of Nanobiotechnology 2022 20:373
  14. Although combination chemoimmunotherapy shows promising clinical results for cancer treatment, this approach is largely restricted by variable objective response rate and severe systemic adverse effects of imm...

    Authors: Jun Gu, Gang Zhao, Jiangkun Yu, Pei Xu, Jiabin Yan, Zhengshuai Jin, Sheng Chen, Yong Wang, Leshuai W. Zhang and Yangyun Wang
    Citation: Journal of Nanobiotechnology 2022 20:372
  15. Colorectal cancer is considered one of the major malignancies that threaten the lives and health of people around the world. Patients with CRC are prone to post-operative local recurrence or metastasis, and so...

    Authors: Yu Guo, Min Wang, Yongbo Zou, Longhai Jin, Zeyun Zhao, Qi Liu, Shuang Wang and Jiannan Li
    Citation: Journal of Nanobiotechnology 2022 20:371
  16. Small extracellular vesicles (sEVs) are an important component in the paracrine pathway. They can be used as a substitute for seed cells and have shown good application prospects in promoting bone regeneration...

    Authors: Ming Dong, Chun Shi, Xinxin Yu, Qian Yang, Saixuan Wu, Runyuan Liu, Tingjiao Liu, Lina Wang and Weidong Niu
    Citation: Journal of Nanobiotechnology 2022 20:370
  17. Immunosuppressive tumor immune microenvironment (TIME) lowers immunotherapy effectiveness. Additionally, low penetration efficiency and unpredictable drug release in tumor areas restrict tumor therapy.

    Authors: Xiaoyan Ge, Yanyun Hao, Hui Li, Huajun Zhao, Yang Liu, Yutong Liu, Xia Li, Hongfei Chen, Jing Zou, Shiying Zhang, Lingling Huang, Gang Shan and Zhiyue Zhang
    Citation: Journal of Nanobiotechnology 2022 20:369
  18. Developing highly efficient pharmaceuticals to eradicate pathogens and facilitate wound healing is of great concern. Despite some cationic carbon dots (CDs) have been used for sterilization, hardly any anionic...

    Authors: Chengjian Mou, Xinyuan Wang, Jiahui Teng, Zhigang Xie and Min Zheng
    Citation: Journal of Nanobiotechnology 2022 20:368
  19. Astrocyte is a key regulator of neuronal activity and excitatory/inhibitory balance via gliotransmission. Recently, gliotransmission has been identified as a novel target for neurological diseases. However, us...

    Authors: Won-Seok Lee, Ji-Hye Kang, Jung-Hwan Lee, Yoo Sung Kim, Jongmin Joseph Kim, Han-Sem Kim, Hae-Won Kim, Ueon Sang Shin and Bo-Eun Yoon
    Citation: Journal of Nanobiotechnology 2022 20:367
  20. Surgery is currently a mainstream treatment modality for various solid tumor indications. However, aggressive resection of tumor tissues frequently causes postoperative complications, which severely undermine ...

    Authors: Yanhua Hou, Yang Fei, Zehong Liu, Yingqi Liu, Menghuan Li and Zhong Luo
    Citation: Journal of Nanobiotechnology 2022 20:366
  21. The failure of orthopedic and dental implants is mainly caused by biomaterial-associated infections and poor osseointegration. Surface modification of biomedical materials plays a significant role in enhancing...

    Authors: Libin Lu, Jiaru Zhang, Kai Guan, Jin Zhou, Fusong Yuan and Yingchun Guan
    Citation: Journal of Nanobiotechnology 2022 20:365
  22. Magnetosomes (BMPs) are organelles of magnetotactic bacteria (MTB) that are responsible for mineralizing iron to form magnetite. In addition, BMP is an ideal biomaterial that is widely used in bio- and nano-te...

    Authors: Junjie Xu, Shijiao Ma, Wei Zhang, Lina Jia, Haolan Zheng, Pang Bo, Xue Bai, Hongyan Sun, Lei Qi, Tongwei Zhang, Chuanfang Chen, Feng Li, Fumihito Arai, Jiesheng Tian and Lin Feng
    Citation: Journal of Nanobiotechnology 2022 20:364
  23. With the success of recent non-viral gene delivery-based COVID-19 vaccines, nanovectors have gained some public acceptance and come to the forefront of advanced therapies. Unfortunately, the relatively low abi...

    Authors: Federica Ponti, Nina Bono, Luca Russo, Paolo Bigini, Diego Mantovani and Gabriele Candiani
    Citation: Journal of Nanobiotechnology 2022 20:363

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:489

  24. Oral delivery of therapeutics is the preferred route of administration due to ease of administration which is associated with greater patient medication adherence. One major barrier to oral delivery and intest...

    Authors: Deepak A. Subramanian, Robert Langer and Giovanni Traverso
    Citation: Journal of Nanobiotechnology 2022 20:362
  25. Ocular drug delivery is one of the most challenging endeavors among the various available drug delivery systems. Despite having suitable drugs for the treatment of ophthalmic disease, we have not yet succeeded...

    Authors: Mehrdad Afarid, Shirin Mahmoodi and Roghayyeh Baghban
    Citation: Journal of Nanobiotechnology 2022 20:361
  26. Exosomes show potential for treating patients with spinal cord injury (SCI) in clinical practice, but the underlying repair mechanisms remain poorly understood, and biological scaffolds available for clinical ...

    Authors: Xiaolie He, Li Yang, Kun Dong, Feng Zhang, Yuchen Liu, Bei Ma, Youwei Chen, Jian Hai, Rongrong Zhu and Liming Cheng
    Citation: Journal of Nanobiotechnology 2022 20:360
  27. The conversion of tumor-promoting M2 macrophage phenotype to tumor-suppressing M1 macrophages is a promising therapeutic approach for cancer treatment. However, the tumor normally provides an abundance of M2 m...

    Authors: Yongmei Zhao, Yuanlin Zheng, Yan Zhu, Hongyun Li, Hongyan Zhu and Tianqing Liu
    Citation: Journal of Nanobiotechnology 2022 20:359
  28. Laccase-based biosensors are efficient for detecting phenolic compounds. However, the instability and high cost of laccases have hindered their practical utilization.

    Authors: Thao Nguyen Le, Xuan Ai Le, Tai Duc Tran, Kang Jin Lee and Moon Il Kim
    Citation: Journal of Nanobiotechnology 2022 20:358
  29. The exosomal miRNA (exo-miRNA) derived from tumor cells contains rich biological information that can effectively aid in the early diagnosis of disease. However, the extremely low abundance imposes stringent r...

    Authors: Xin Gao, Haiping Wu, Yujian Li, Lu Zhang, Mingxuan Song, Xuhuai Fu, Rui Chen, Shijia Ding, Jiawei Zeng, Jia Li and Ping Liu
    Citation: Journal of Nanobiotechnology 2022 20:357
  30. Due to their prevalence, dental caries ranks first among all diseases endangering human health. Therefore, the prevention of caries is of great significance, as caries have become a serious public health probl...

    Authors: Luting Weng, Lang Wu, Rongjuan Guo, Jiajia Ye, Wen Liang, Wei Wu, Liang Chen and Deqin Yang
    Citation: Journal of Nanobiotechnology 2022 20:356
  31. The CRISPR-Cas9 technology has changed the landscape of genome editing and has demonstrated extraordinary potential for treating otherwise incurable diseases. Engineering strategies to enable efficient intrace...

    Authors: Tianxu Fang, Xiaona Cao, Mysha Ibnat and Guojun Chen
    Citation: Journal of Nanobiotechnology 2022 20:354
  32. Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to prevent and treat cisplatin-induced acute kidney injury (AKI). Ho...

    Authors: Peipei Wu, Yuting Tang, Can Jin, Min Wang, Linli Li, Zhong Liu, Hui Shi, Zixuan Sun, Xiaomei Hou, Wenya Chen, Wenrong Xu and Hui Qian
    Citation: Journal of Nanobiotechnology 2022 20:353
  33. Fullerenol, a functional and water-soluble fullerene derivative, plays an important role in antioxidant, antitumor and antivirus, implying its enormous potential in biomedical applications. However, the in viv...

    Authors: Yingying Zha, Yan Jin, Xinxing Wang, Lin Chen, Xulai Zhang and Ming Wang
    Citation: Journal of Nanobiotechnology 2022 20:348
  34. Coronaviruses usually cause mild respiratory disease in humans but as seen recently, some human coronaviruses can cause more severe diseases, such as the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-C...

    Authors: Marta L. DeDiego, Yadileiny Portilla, Neus Daviu, Darío López-García, Laura Villamayor, Vladimir Mulens-Arias, Jesús G. Ovejero, Álvaro Gallo-Cordova, Sabino Veintemillas-Verdaguer, M. Puerto Morales and Domingo F. Barber
    Citation: Journal of Nanobiotechnology 2022 20:352
  35. The efficacy of immune checkpoint blockade (ICB), in the treatment of hepatocellular carcinoma (HCC), is limited due to low levels of tumor-infiltrating T lymphocytes and deficient checkpoint blockade in this ...

    Authors: Yuan-Fei Lu, Jia-Ping Zhou, Qiao-Mei Zhou, Xiao-Yan Yang, Xiao-Jie Wang, Jie-Ni Yu, Jin-Guo Zhang, Yong-Zhong Du and Ri-Sheng Yu
    Citation: Journal of Nanobiotechnology 2022 20:351
  36. Magnetic resonance imaging (MRI) has been widely using in clinical diagnosis, and contrast agents (CAs) can improve the sensitivity MRI. To overcome the problems of commercial Gd chelates-based T1 CAs, commercial...

    Authors: Xuanyi Lu, Huimin Zhou, Zhiyu Liang, Jie Feng, Yudie Lu, Lin Huang, Xiaozhong Qiu, Yikai Xu and Zheyu Shen
    Citation: Journal of Nanobiotechnology 2022 20:350
  37. Non-alcoholic fatty liver disease (NAFLD) is a usual chronic liver disease and lacks non-invasive biomarkers for the clinical diagnosis and prognosis. Extracellular vesicles (EVs), a group of heterogeneous sma...

    Authors: Qingfu Zhu, Hengrui Li, Zheng Ao, Hao Xu, Jiaxin luo, Connor Kaurich, Rui Yang, Pei-Wu Zhu, Sui-Dan Chen, Xiao-Dong Wang, Liang-Jie Tang, Gang Li, Ou-Yang Huang, Ming-Hua Zheng, Hui-Ping Li and Fei Liu
    Citation: Journal of Nanobiotechnology 2022 20:349
  38. The disease caused by plant pathogenic bacteria in the production, transportation, and storage of many crops has brought huge losses to agricultural production. N-acylhomoserine lactonases (AHLases) can quench qu...

    Authors: Yan Chen, Pengfu Liu, Jiequn Wu, Wanqing Yan, Saixue Xie, Xuanrong Sun, Bang-Ce Ye and Xiaohe Chu
    Citation: Journal of Nanobiotechnology 2022 20:347
  39. Endogenous hydrogen sulfide (H2S)-responsive theranostic agents have attracted extensive attention due to their specificity for colon cancer. However, the development of such agents with high enrichment in tumors...

    Authors: Yuying Cheng, Haiji Bo, Ruomeng Qin, Fulai Chen, Fengfeng Xue, Lu An, Gang Huang and Qiwei Tian
    Citation: Journal of Nanobiotechnology 2022 20:346
  40. Nanovaccines, a new generation of vaccines that use nanoparticles as carriers and/or adjuvants, have been widely used in the prevention and treatment of various diseases, including cancer. Nanovaccines have sp...

    Authors: Zhiyun Liao, Jing Huang, Pui-Chi Lo, Jonathan F. Lovell, Honglin Jin and Kunyu Yang
    Citation: Journal of Nanobiotechnology 2022 20:345
  41. Cancer remains a serious threat to human health owing to the lack of effective treatments. Photodynamic therapy (PDT) has emerged as a promising non-invasive cancer treatment that consists of three main elemen...

    Authors: Zijuan Meng, Huiying Xue, Tingting Wang, Biao Chen, Xiyuan Dong, Lili Yang, Jun Dai, Xiaoding Lou and Fan Xia
    Citation: Journal of Nanobiotechnology 2022 20:344
  42. Promoting diabetic wound healing is still a challenge, and angiogenesis is believed to be essential for diabetic wound healing. Vermiculite is a natural clay material that is very easy to obtain and exhibits e...

    Authors: Xingtai Huang, Qirui Wang, Runyi Mao, Zeying Wang, Steve G.F. Shen, Juan Mou and Jiewen Dai
    Citation: Journal of Nanobiotechnology 2022 20:343
  43. Delayed wound healing remains a challenge, and macrophages play an important role in the inflammatory process of wound healing. Morphological changes in macrophages can affect their phenotype, but little is kn...

    Authors: Jian Xie, Xiaowei Wu, Shang Zheng, Kaili Lin and Jiansheng Su
    Citation: Journal of Nanobiotechnology 2022 20:342
  44. Nowadays, nanoparticles (NPs) have evolved as multifunctional systems combining different custom anchorages which opens a wide range of applications in biomedical research. Thus, their pharmacological involvem...

    Authors: Ángela-Patricia Hernández, Ania Micaelo, Rafael Piñol, Marina L. García-Vaquero, José J. Aramayona, Julio J. Criado, Emilio Rodriguez, José Ignacio Sánchez-Gallego, Alicia Landeira-Viñuela, Pablo Juanes-Velasco, Paula Díez, Rafael Góngora, Ricardo Jara-Acevedo, Alberto Orfao, Javier Miana-Mena, María Jesús Muñoz…
    Citation: Journal of Nanobiotechnology 2022 20:341
  45. Currently, systemic therapies for patients with advanced-stage hepatocellular carcinoma (HCC) rely mainly on systemic drugs. However, traditional systemic drugs have a high rate of serious adverse events, and ...

    Authors: Yongshun Zheng, Ran Jia, Jun Li, Xiaohe Tian and Yeben Qian
    Citation: Journal of Nanobiotechnology 2022 20:339

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