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  1. Designing new oxygenation nanomaterials by oxygen-generating or oxygen-carrying strategies in hypoxia-associated anti-tumor therapy is a high priority target yet challenge. In this work, we fabricated a nanopl...

    Authors: Wenyao Duan, Bo Li, Wen Zhang, Jiaqi Li, Xin Yao, Yupeng Tian, Jun Zheng and Dandan Li
    Citation: Journal of Nanobiotechnology 2022 20:217
  2. Blockade of programmed cell death 1 ligand (PD-L1) has been used to treat triple-negative breast cancer (TNBC), and various strategies are under investigation to improve the treatment response rate. Inhibition...

    Authors: Yuxia Tang, Siqi Wang, Yang Li, Chen Yuan, Jie Zhang, Ziqing Xu, Yongzhi Hu, Haibin Shi and Shouju Wang
    Citation: Journal of Nanobiotechnology 2022 20:216
  3. Immunotherapy has gradually emerged as the most promising anticancer therapy. In addition to conventional anti-PD-1/PD-L1 therapy, anti-CTLA-4 therapy, CAR-T therapy, etc., immunotherapy can also be induced by...

    Authors: Yinan Ding, Luhong Wang, Han Li, Fengqin Miao, Zhiyuan Zhang, Chunmei Hu, Weiping Yu, Qiusha Tang and Guoliang Shao
    Citation: Journal of Nanobiotechnology 2022 20:214
  4. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic disease with pathophysiological characteristics of transforming growth factor-β (TGF-β), and reactive oxygen species (ROS)-induced excessive fibrob...

    Authors: Junzhao Liu, Zuohong Wu, Yadong Liu, Zhu Zhan, Liping Yang, Can Wang, Qinqin Jiang, Haitao Ran, Pan Li and Zhigang Wang
    Citation: Journal of Nanobiotechnology 2022 20:213
  5. A sort of composite hydrogel with good biocompatibility, suppleness, high conductivity, and anti-inflammatory activity based on polyvinyl alcohol (PVA) and molybdenum sulfide/graphene oxide (MoS2/GO) nanomaterial...

    Authors: Lingling Chen, Wanshun Wang, Zefeng Lin, Yao Lu, Hu Chen, Binglin Li, Zhan Li, Hong Xia, Lihua Li and Tao Zhang
    Citation: Journal of Nanobiotechnology 2022 20:210
  6. Multidrug resistance is still a major obstacle to cancer treatment. The most studies are to inhibit the activity of the drug transporter P-glycoprotein (P-gp), but the effect is not ideal. Herein, a nanosystem...

    Authors: Bin Du, Mei Zheng, Huizhen Ma, Jingshu Huang, Qingqing Jiao, Yimeng Bai, Mengmeng Zhao and Jie Zhou
    Citation: Journal of Nanobiotechnology 2022 20:209
  7. Pancreatic ductal adenocarcinoma (PDAC) interacts closely with the tumor microenvironment (TME). The TME is remodeled by crosstalk between pancreatic cancer cells and stromal cells, and is critical for cancer ...

    Authors: Ying Li, Wenjing Zhao, Yanli Wang, Haiyan Wang and Shanglong Liu
    Citation: Journal of Nanobiotechnology 2022 20:208
  8. As a typical class of crystalline porous materials, metal–organic framework possesses unique features including versatile functionality, structural and compositional tunability. After being reduced to two-dime...

    Authors: Weiqi Wang, Yuting Yu, Yilan Jin, Xiao Liu, Min Shang, Xiaohua Zheng, Tingting Liu and Zhigang Xie
    Citation: Journal of Nanobiotechnology 2022 20:207
  9. Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by diffuse inflammation of the colonic mucosa and a relapsing and remitting course. The current therapeutics are only modestly effec...

    Authors: Cui Liu, Xiangji Yan, Yujie Zhang, Mei Yang, Yana Ma, Yuanyuan Zhang, Qiuran Xu, Kangsheng Tu and Mingzhen Zhang
    Citation: Journal of Nanobiotechnology 2022 20:206
  10. The reactive oxygen species (ROS) and inflammation, a critical contributor to tissue damage, is well-known to be associated with various disease. The kidney is susceptible to hypoxia and vulnerable to ROS. Thu...

    Authors: Hong Sang Choi, Ansuja Pulickal Mathew, Saji Uthaman, Arathy Vasukutty, In Jin Kim, Sang Heon Suh, Chang Seong Kim, Seong Kwon Ma, Sontyana Adonijah Graham, Soo Wan Kim, In-Kyu Park and Eun Hui Bae
    Citation: Journal of Nanobiotechnology 2022 20:205
  11. Glypican-3 (GPC3), a membrane-bound heparan sulfate proteoglycan, is a biomarker of hepatocellular carcinoma (HCC) progression. Aptamers specifically binding to target biomolecules have recently emerged as cli...

    Authors: Woo-Ri Shin, Dae-Young Park, Ji Hun Kim, Jin-Pyo Lee, Nguyen Quang Thai, In-Hwan Oh, Simranjeet Singh Sekhon, Wooil Choi, Sung Yeon Kim, Byung-Kwan Cho, Sun Chang Kim, Jiho Min, Ji-Young Ahn and Yang-Hoon Kim
    Citation: Journal of Nanobiotechnology 2022 20:204
  12. Photodynamic therapy (PDT) is a promising antitumor strategy with fewer adverse effects and higher selectivity than conventional therapies. Recently, a series of reports have suggested that PDT induced by Cere...

    Authors: Ruijie Qian, Kun Wang, Yawen Guo, Hongyan Li, Ziyang Zhu, Xiaojuan Huang, Chengpeng Gong, Yu Gao, Rong Guo, Biao Yang, Chenyang Wang, Dawei Jiang, Xiaoli Lan, Rui An and Zairong Gao
    Citation: Journal of Nanobiotechnology 2022 20:203
  13. As a non-invasive innovative diagnosis platform, advanced flexible contact lenses can dynamically monitor vital ocular indicators, spot abnormalities and provide biofeedback guidance for real-time diagnosis an...

    Authors: Maowen Xie, Guang Yao, Tianyao Zhang, Qian Wang, Xiaoyi Mo, Qiwei Dong, Wenhao Lou, Fang Lu, Taisong Pan, Min Gao, Dawei Jiang, Kangning Zhao and Yuan Lin
    Citation: Journal of Nanobiotechnology 2022 20:202
  14. Chronic wounds represent a major challenge to the present healthcare system. In recent decades, many topical therapies have been investigated for the treatment of chronic wounds, including different types of w...

    Authors: Ke Jian, Chenghao Yang, Tingting Li, Xia Wu, Jun Shen, Jiaying Wei, Zhimou Yang, Dan Yuan, Mingyi Zhao and Junfeng Shi
    Citation: Journal of Nanobiotechnology 2022 20:201
  15. Authors: Changchang Jia, Fan Zhang, Jiamei Lin, Liwen Feng, Tiantian Wang, Yuan Feng, Feng Yuan, Yang Mai, Xiaowei Zeng and Qi Zhang
    Citation: Journal of Nanobiotechnology 2022 20:200

    The original article was published in Journal of Nanobiotechnology 2022 20:90

  16. Ferroptosis holds promise as a potential tumor therapy by programming cell death with a hallmark of reactive oxygen species (ROS)-induced lipid peroxidation. However, vigorous energy metabolism may assist tumo...

    Authors: Yanqiu Wang, Jie Chen, Jianxiu Lu, Juqun Xi, Zhilong Xu, Lei Fan, Hua Dai and Lizeng Gao
    Citation: Journal of Nanobiotechnology 2022 20:199
  17. Neural stem cells (NSCs) have the ability to generate a variety of functional neural cell types and have a high potential for neuronal cell regeneration and recovery. Thus, they been recognized as the best sou...

    Authors: Eun Ji Lee, Yoori Choi, Hong J. Lee, Do Won Hwang and Dong Soo Lee
    Citation: Journal of Nanobiotechnology 2022 20:198
  18. By 2050, the world population will increase to 10 billion which urged global demand for food production to double. Plant disease and land drought will make the situation more dire, and safer and environment-fr...

    Authors: Jianfeng Du, Baoyou Liu, Tianfeng Zhao, Xinning Xu, Han Lin, Yatai Ji, Yue Li, Zhiwei Li, Chongchong Lu, Pengan Li, Haipeng Zhao, Yang Li, Ziyi Yin and Xinhua Ding
    Citation: Journal of Nanobiotechnology 2022 20:197
  19. Steatotic livers tolerate ischemia–reperfusion injury (IRI) poorly, increasing the risk of organ dysfunction. Ferroptosis is considered the initiating factor of organ IRI. Heme oxygenase oxygen-1 (HO-1)-modifi...

    Authors: Longlong Wu, Xuan Tian, Huaiwen Zuo, Weiping Zheng, Xiang Li, Mengshu Yuan, Xiaorong Tian and Hongli Song
    Citation: Journal of Nanobiotechnology 2022 20:196
  20. The rapid spread of infectious bacteria has brought great challenges to public health. It is imperative to explore effective and environment-friendly antibacterial modality to defeat antibiotic-resistant bacte...

    Authors: Yangzi Yang, Chengwei Wang, Ning Wang, Jiaxin Li, Yingchun Zhu, Jiantao Zai, Jingke Fu and Yongqiang Hao
    Citation: Journal of Nanobiotechnology 2022 20:195
  21. As a natural product with various biological activities, triptolide (TP) has been reported in anti-inflammatory, anti-tumor and anti-autoimmune studies. However, the narrow therapeutic window, poor water solub...

    Authors: Rui Sun, Jingyue Dai, Mingjian Ling, Ling Yu, Zhiqiang Yu and Longguang Tang
    Citation: Journal of Nanobiotechnology 2022 20:194
  22. Different from Fe ions in Fenton reaction, Mn ions can function both as catalyst for chemodynamic therapy and immune adjuvant for antitumor immune responses. In Mn-mediated Fenton-like reaction, bicarbonate (

    Authors: Yushuo Feng, Yaqing Liu, Xiaoqian Ma, Lihua Xu, Dandan Ding, Lei Chen, Zongzhang Wang, Ruixue Qin, Wenjing Sun and Hongmin Chen
    Citation: Journal of Nanobiotechnology 2022 20:193
  23. Authors: Shibo Xu, Linna Chang, Yanan Hu, Xingjun Zhao, Shuocheng Huang, Zhenhua Chen, Xiuli Ren and Xifan Mei
    Citation: Journal of Nanobiotechnology 2022 20:192

    The original article was published in Journal of Nanobiotechnology 2021 19:362

  24. Nanoplastics have been recently found widely distributed in our natural environment where ubiquitously bacteria are major participants in various material cycles. Understanding how nanoplastics interact with b...

    Authors: Shang Dai, Rui Ye, Jianxiang Huang, Binqiang Wang, Zhenming Xie, Xinwen Ou, Ning Yu, Cheng Huang, Yuejin Hua, Ruhong Zhou and Bing Tian
    Citation: Journal of Nanobiotechnology 2022 20:191
  25. Neoantigens are considered ideal targets for immunotherapy, especially tumor vaccine, because of their strong specificity and immunogenicity. Here, we developed a neoantigen nanovaccine used liposomes with lym...

    Authors: Yanhong Chu, Lingyu Qian, Yaohua Ke, Xiaoyu Feng, Xinjie Chen, Fangcen Liu, Lixia Yu, Lianru Zhang, Yaping Tao, Rui Xu, Jia Wei, Baorui Liu and Qin Liu
    Citation: Journal of Nanobiotechnology 2022 20:190
  26. Extracellular vesicles (EVs), spherical biological vesicles, mainly contain nucleic acids, proteins, lipids and metabolites for biological information transfer between cells. Microparticles (MPs), a subtype of...

    Authors: Yan Hu, Yajie Sun, Chao Wan, Xiaomeng Dai, Shuhui Wu, Pui-Chi Lo, Jing Huang, Jonathan F. Lovell, Honglin Jin and Kunyu Yang
    Citation: Journal of Nanobiotechnology 2022 20:189
  27. Calcium ions (Ca2+) participates in various intracellular signal cascades and especially plays a key role in pathways relevant to cancer cells. Mitochondrial metabolism stimulated by calcium overload can trigger ...

    Authors: Ying Zhou, Shisong Jing, Sainan Liu, Xizhong Shen, Lihan Cai, Changfeng Zhu, Yicheng Zhao and Maolin Pang
    Citation: Journal of Nanobiotechnology 2022 20:188
  28. Non-redundant properties such as hypoxia and acidosis promote tumor metabolic adaptation and limit anti-cancer therapies. The key to the adaptation of tumor cells to hypoxia is the transcriptional and stable e...

    Authors: Jie Liu, Xiaochun Hu, Lei Feng, Yun Lin, Shujing Liang, Zhounan Zhu, Shuo Shi and Chunyan Dong
    Citation: Journal of Nanobiotechnology 2022 20:187
  29. Sonodynamic therapy (SDT) is a burgeoning modality for cancer therapy owing to its high tissue-penetrating capability, controllability and safety. Whereas, the undesirable reactive oxygen species (ROS) yield o...

    Authors: Xiaohui Qiao, Liyun Xue, Hui Huang, Xinyue Dai, Yu Chen and Hong Ding
    Citation: Journal of Nanobiotechnology 2022 20:186
  30. Albumin-biomineralized copper sulfide nanoparticles (Cu2−xS NPs) have attracted much attention as an emerging phototheranostic agent due to their advantages of facile preparation method and high biocompatibility....

    Authors: Ya-Nan Xia, He Zu, Haoxiang Guo, Tianyan Jiang, Siqi Yang, Huan Yu, Shaodian Zhang, Heng Ding, Xiaoyu Li, Yangyun Wang, Yong Wang and Leshuai W. Zhang
    Citation: Journal of Nanobiotechnology 2022 20:185
  31. Effective and accurate screening of oncological biomarkers in peripheral blood circulation plays an increasingly vital role in diagnosis and prognosis. High-sensitivity assays can effectively aid clinical deci...

    Authors: Mengyao Liu, Yonghong Li, Wei Xing, Yuqin Zhang, Xi Xie, Jiadong Pang, Fangjian Zhou and Jiang Yang
    Citation: Journal of Nanobiotechnology 2022 20:184
  32. Pine wilt disease as a devastating forest disaster result from Bursaphelenchus xylophilus that spread by stem-borers Monochamus alternatus feeding on pine leaves, which has brought inestimable economic losses to ...

    Authors: Yanxue Liu, Gehui Wang, Yixiao Qin, Long Chen, Chenggang Zhou, Luqin Qiao, Huixiang Liu, Chunyan Jia, Jiandu Lei and Yingchao Ji
    Citation: Journal of Nanobiotechnology 2022 20:183
  33. Citrus production and trading are seriously affected by fungal decays worldwide; the green mold infection by Penicillium digitatum could be the most disastrous. The substitutions of chemical and synthetic fungici...

    Authors: Mohamed F. Salem, Wessam A. Abd-Elraoof, Ahmed A. Tayel, Fahad M. Alzuaibr and Osama M. Abonama
    Citation: Journal of Nanobiotechnology 2022 20:182
  34. Cancer immunotherapy is limited by the immune escape of tumor cells and adverse effects. Photo-immunotherapy, the combination of immunotherapy and phototherapy (such as photodynamic therapy (PDT) and photother...

    Authors: Juan Yue, Qian Mei, Panyong Wang, Peng Miao, Wen-Fei Dong and Li Li
    Citation: Journal of Nanobiotechnology 2022 20:181
  35. Outbreaks of infection due to multidrug-resistant (MDR) bacteria, especially Gram-negative bacteria, have become a global health issue in both hospitals and communities. Antisense oligonucleotides (ASOs) based...

    Authors: Zhou Chen, Yue Hu, Xinggang Mao, Dan Nie, Hui Zhao, Zheng Hou, Mingkai Li, Jingru Meng, Xiaoxing Luo and Xiaoyan Xue
    Citation: Journal of Nanobiotechnology 2022 20:180
  36. Transcatheter arterial chemoembolization (TACE) is one of the main palliative therapies for advanced hepatocellular carcinoma (HCC), which is also regarded as a promising therapeutic strategy for cancer treatm...

    Authors: Minjiang Chen, Jie Li, Gaofeng Shu, Lin Shen, Enqi Qiao, Nannan Zhang, Shiji Fang, Xiaoxiao Chen, Zhongwei Zhao, Jianfei Tu, Jingjing Song, Yongzhong Du and Jiansong Ji
    Citation: Journal of Nanobiotechnology 2022 20:179
  37. Local hypoxia is a common feature of many solid tumors and may lead to unsatisfactory chemotherapy outcomes. Anaerobic bacteria that have an affinity to hypoxic areas can be used to achieve targeted drug deliv...

    Authors: Susu Xiao, Huan Shi, Yan Zhang, Yu Fan, Li Wang, Li Xiang, Yanlin Liu, Ling Zhao and Shaozhi Fu
    Citation: Journal of Nanobiotechnology 2022 20:178
  38. Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While the widely application of siRNAs in cancer treatment is s...

    Authors: Ting Zhao, Ce Liang, Yanrong Zhao, Xiangdong Xue, Zhao Ma, Jinlong Qi, Haitao Shen, Shaokun Yang, Jia Zhang, Qingzhong Jia, Qing Du, Deying Cao, Bai Xiang, Hailin Zhang and Xianrong Qi
    Citation: Journal of Nanobiotechnology 2022 20:177
  39. Stem cells from human exfoliated deciduous teeth (SHED) can be used as a potential clinical material. But the use of xenogeneic ingredients will increase the risk of zoonotic disease transmission. Human platel...

    Authors: Tong Lei, Yanyan Liu, Shiwen Deng, Zhuangzhuang Xiao, Yanjie Yang, Xiaoshuang Zhang, Wangyu Bi and Hongwu Du
    Citation: Journal of Nanobiotechnology 2022 20:176
  40. Pathological retinal angiogenesis resulting from a variety of ocular diseases including oxygen induced retinopathy, diabetic retinopathy and ocular vein occlusion, is one of the major reasons for vision loss, ...

    Authors: Na Zhao, Xiao Gui, Qian Fang, Rui Zhang, Weiye Zhu, Haorui Zhang, Qing Li, Yukun Zhou, Jiawei Zhao, Xiao Cui, Guangping Gao, Huipeng Tang, Ni Shen, Taoyong Chen, Hongyuan Song and Wei Shen
    Citation: Journal of Nanobiotechnology 2022 20:174
  41. Authors: John Joseph, Vito Domenico Bruno, Nadiah Sulaiman, Alexander Ward, Thomas W. Johnson, Helna Mary Baby, Shantikumar V. Nair, Deepthy Menon, Sarah Jane George, Raimondo Ascione, Praveen Kerala Varma and Rajesh Jose
    Citation: Journal of Nanobiotechnology 2022 20:173

    The original article was published in Journal of Nanobiotechnology 2022 20:71

  42. The identification of indeterminate pulmonary nodules (IPNs) following a low-dose computed tomography (LDCT) is a major challenge for early diagnosis of lung cancer. The inadequate assessment of IPNs’ malignan...

    Authors: Di Zheng, Yuming Zhu, Jiyang Zhang, Wei Zhang, Huizhen Wang, Hao Chen, Chunyan Wu, Jian Ni, Xiaoya Xu, Baoning Nian, Sheng Chen, Beibei Wang, Xiaofang Li, Yanan Zhang, Jiatao Zhang, Wenzhao Zhong…
    Citation: Journal of Nanobiotechnology 2022 20:172
  43. Budding yeast, Saccharomyces cerevisiae, has been extensively favored as a model organism in aging and age-related studies, thanks to versatile microfluidic chips for cell dynamics assay and replicative lifespan ...

    Authors: Yingying Wang, Zhen Zhu, Ke Liu, Qin Xiao, Yangye Geng, Feng Xu, Shuiping Ouyang, Ke Zheng, Yimin Fan, Nan Jin, Xiangwei Zhao, Mario A. Marchisio, Dejing Pan and Qing-an Huang
    Citation: Journal of Nanobiotechnology 2022 20:171
  44. Contrast-enhanced MR angiography (MRA) is a critical technique for vascular imaging. Nevertheless, the efficacy of MRA is often limited by the low rate of relaxation, short blood-circulation time, and metal io...

    Authors: Zhuang Liu, Menglong Zhao, Han Wang, Zi Fu, Hongbo Gao, Weijun Peng, Dalong Ni, Wei Tang and Yajia Gu
    Citation: Journal of Nanobiotechnology 2022 20:170
  45. Mebendazole (MBZ) is a well-known anti-parasite drug with significant anti-cancer properties. However, MBZ exhibits low solubility, limited absorption efficacy, extensive first-pass effect, and low bioavailabi...

    Authors: Amirhosein Kefayat, Maryam Hosseini, Fatemeh Ghahremani, Nafise Arbab Jolfaie and Mohammad Rafienia
    Citation: Journal of Nanobiotechnology 2022 20:169
  46. The study of symbiotic nitrogen fixation between (SNF) legumes and rhizobia has always been a hot frontier in scientific research. Nanotechnology provides a new strategy for biological nitrogen fixation resear...

    Authors: Jun Ma, Yi Zhou, Jiaying Li, Zhiyong Song and Heyou Han
    Citation: Journal of Nanobiotechnology 2022 20:168
  47. Salmonella Enteritidis (S. Enteritidis) being one of the most prevalent foodborne pathogens worldwide poses a serious threat to public safety. Prevention of zoonotic infectious disease and controlling the risk of...

    Authors: Kui Gu, Zengxu Song, Changyu Zhou, Peng Ma, Chao Li, Qizhong Lu, Ziwei Liao, Zheren Huang, Yizhi Tang, Hao Li, Yu Zhao, Wenjun Yan, Changwei Lei and Hongning Wang
    Citation: Journal of Nanobiotechnology 2022 20:167
  48. Browning of white adipose tissue (WAT) is a particularly appealing target for therapeutics in the treatment of obesity and related metabolic diseases. Although small extracellular vesicles (sEVs) released from...

    Authors: Yan Zhang, Mei Yu, Jia Dong, Yue Wu and Weidong Tian
    Citation: Journal of Nanobiotechnology 2022 20:165
  49. Mesenchymal stem cells (MSCs) exosomes were previously shown to be effective in articular cartilage repairing. However, whether MSCs exosomes promote mature cartilage formation of microtia chondrocytes and the...

    Authors: Jianguo Chen, Tianyu Huang, Ruiquan Liu, Chenyu Wang, Haiyue Jiang and Hengyun Sun
    Citation: Journal of Nanobiotechnology 2022 20:164

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