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  1. Nowadays, brain tumors are challenging problems, and the key of therapy is ensuring therapeutic drugs cross the blood–brain barrier (BBB) effectively. Although the efficiency of drug transport across the BBB c...

    Authors: Shuo Zhang, Shuai Zhang, Siyuan Luo, Peng Tang, Mingxi Wan, Daocheng Wu and Wei Gao
    Citation: Journal of Nanobiotechnology 2022 20:287
  2. Circulating miRNAs in the blood can regulate disease development and thus indicate disease states via their various expression levels. For these reasons, circulating miRNAs constitute useful biomarkers, and an...

    Authors: Yudie Sun, La Fang, Yang Yi, Aobo Feng, Kui Zhang and Jing-Juan Xu
    Citation: Journal of Nanobiotechnology 2022 20:285
  3. Sonodynamic therapy (SDT) induces immunogenic cell death (ICD) in tumors and promises to play an assistive role in immunotherapy in pancreatic cancer. However, the short half-life and limited diffusion distanc...

    Authors: Jifan Chen, Liting Feng, Peile Jin, Jiaxin Shen, Jiayue Lu, Yue Song, Guowei Wang, Qin Chen, Deyi Huang, Ying Zhang, Chao Zhang, Youfeng Xu and Pintong Huang
    Citation: Journal of Nanobiotechnology 2022 20:283
  4. Nanotopographical cues play a critical role as drivers of mesenchymal stem cell differentiation. Nanowire scaffolds, in this regard, provide unique and adaptable nanostructured surfaces with focal points for a...

    Authors: Jose E. Perez, Bashaer Bajaber, Nouf Alsharif, Aldo I. Martínez-Banderas, Niketan Patel, Ainur Sharip, Enzo Di Fabrizio, Jasmeen Merzaban and Jürgen Kosel
    Citation: Journal of Nanobiotechnology 2022 20:282
  5. Oral chemotherapy is preferred for patients with cancer owing to its multiple advantages, including convenience, better patient compliance, and improved safety. Nevertheless, various physical barriers exist in...

    Authors: Wei Liu, Ying Han, Xin Xin, Liqing Chen, Yanhong Liu, Chao Liu, Xintong Zhang, Mingji Jin, Jingzhe Jin, Zhonggao Gao and Wei Huang
    Citation: Journal of Nanobiotechnology 2022 20:281

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:541

  6. As an antioxidant, hydrogen (H2) can selectively react with the highly toxic hydroxyl radical (·OH) in tumor cells to break the balance of reactive oxygen species (ROS) and cause oxidative stress. However, due to...

    Authors: Hongyu Yan, Miao Fan, Huifang Liu, Tingshan Xiao, Dandan Han, Ruijun Che, Wei Zhang, Xiaohan Zhou, June Wang, Chi Zhang, Xinjian Yang, Jinchao Zhang and Zhenhua Li
    Citation: Journal of Nanobiotechnology 2022 20:280
  7. Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor ...

    Authors: Ying Zhang, Qiqi Liu, Xinmeng Zhang, Haoqiang Huang, Shiqi Tang, Yujuan Chai, Zhourui Xu, Meirong Li, Xin Chen, Jia Liu and Chengbin Yang
    Citation: Journal of Nanobiotechnology 2022 20:279
  8. As Traditional Chinese Medicine (TCM) drugs, Huangqi and Danshen are always applied in combination for spinal cord injury (SCI) treatment based on the compatibility theory of TCM. Astragalus Polysaccharidesis ...

    Authors: Siyuan Rao, Yongpeng Lin, Rui Lin, Jinggong Liu, Hongshen Wang, Weixiong Hu, Bolai Chen and Tianfeng Chen
    Citation: Journal of Nanobiotechnology 2022 20:278
  9. Cancer immunotherapy is a novel therapeutic regimen because of the specificity and durability of immune modulations to treat cancers. Current cancer immunotherapy is limited by some barriers such as poor respo...

    Authors: Su-Ran Li, Fang-Yi Huo, Han-Qi Wang, Jing Wang, Chun Xu, Bing Liu and Lin-Lin Bu
    Citation: Journal of Nanobiotechnology 2022 20:277
  10. In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of treatment modality to a larg...

    Authors: Seyed Hossein Kiaie, Naime Majidi Zolbanin, Armin Ahmadi, Rafieh Bagherifar, Hadi Valizadeh, Fatah Kashanchi and Reza Jafari
    Citation: Journal of Nanobiotechnology 2022 20:276
  11. Sustainable agriculture is an important conception to meet the growing food demand of the global population. The increased need for adequate and safe food, as well as the ongoing ecological destruction associa...

    Authors: Mahpara Safdar, Woochan Kim, Sunho Park, Yonghyun Gwon, Yeon-Ok Kim and Jangho Kim
    Citation: Journal of Nanobiotechnology 2022 20:275
  12. The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and re...

    Authors: Ganji Seeta Rama Raju, Eluri Pavitra, Ganji Lakshmi Varaprasad, Sai Samyuktha Bandaru, Ganji Purnachandra Nagaraju, Batoul Farran, Yun Suk Huh and Young-Kyu Han
    Citation: Journal of Nanobiotechnology 2022 20:274
  13. Acute lung injury (ALI), a severe health-threatening disease, has a risk of causing chronic pulmonary fibrosis. Informative and powerful evidence suggests that inflammation and oxidative stress play a central ...

    Authors: Yi-Bing Chen, Ya-Bin Zhang, Yu-Le Wang, Prabhleen Kaur, Bo-Guang Yang, Yan Zhu, Lei Ye and Yuan-Lu Cui
    Citation: Journal of Nanobiotechnology 2022 20:272
  14. Circulating tumour DNA (ctDNA) has emerged as an ideal biomarker for the early diagnosis and prognosis of gastric cancer (GC). In this work, a pump-free, high-throughput microfluidic chip coupled with catalyti...

    Authors: Xiaowei Cao, Shengjie Ge, Weiwei Hua, Xinyu Zhou, Wenbo Lu, Yingyan Gu, Zhiyue Li and Yayun Qian
    Citation: Journal of Nanobiotechnology 2022 20:271
  15. NRF2 is the key antioxidant molecule to maintain redox homeostasis, however the intrinsic mechanisms of NRF2 activation in the context of nanoparticles (NPs) exposure remain unclear. In this study, we revealed...

    Authors: Na Li, Hang Du, Lejiao Mao, Ge Xu, Mengling Zhang, Yinzhen Fan, Xiaomei Dong, Lijun Zheng, Bin Wang, Xia Qin, Xuejun Jiang, Chengzhi Chen, Zhen Zou and Jun Zhang
    Citation: Journal of Nanobiotechnology 2022 20:270
  16. RNA viruses periodically trigger pandemics of severe human diseases, frequently causing enormous economic losses. Here, a nucleic acid extraction-free and amplification-free RNA virus testing probe was propose...

    Authors: Fuyu Du, Weijie Zhang, Huimin Yao, Yuqiong Xia, Xianghan Zhang, Peng Yang and Pengbo Ning
    Citation: Journal of Nanobiotechnology 2022 20:269
  17. Excessive accumulation of reactive oxygen species (ROS) has been documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However, numerous antioxidants have failed in clinical studies pa...

    Authors: Jiayi Gu, Xueling Wang, Yuming Chen, Ke Xu, Dehong Yu and Hao Wu
    Citation: Journal of Nanobiotechnology 2022 20:268
  18. Triple-negative breast cancer (TNBC) is a highly heterogeneous breast cancer subtype with poor prognosis. Although anatomical imaging figures prominently for breast lesion screening, TNBC is often misdiagnosed...

    Authors: Natacha Jugniot, Tarik F. Massoud, Jeremy J. Dahl and Ramasamy Paulmurugan
    Citation: Journal of Nanobiotechnology 2022 20:267
  19. Surgical resection to achieve tumor-free margins represents a difficult clinical scenario for patients with hepatocellular carcinoma. While post-surgical treatments such as chemotherapy and radiotherapy can de...

    Authors: Wentao Dang, Wei-Chih Chen, Enguo Ju, Yanteng Xu, Kai Li, Haixia Wang, Kun Wang, Shixian Lv, Dan Shao, Yu Tao and Mingqiang Li
    Citation: Journal of Nanobiotechnology 2022 20:266
  20. Overproduced reactive oxygen and reactive nitrogen species (RONS) in the brain are involved in the pathogenesis of several neurological diseases, such as Alzheimer's disease, Parkinson's disease, traumatic bra...

    Authors: Yanping Jiang, Yiyuan Kang, Jia Liu, Suhan Yin, Zhendong Huang and Longquan Shao
    Citation: Journal of Nanobiotechnology 2022 20:265
  21. The application of chemodynamic therapy (CDT) for cancer is a serious challenge owing to the low efficiency of the Fenton catalyst and insufficient H2O2 expression in cells. Herein, we fabricated a PDGFB targetin...

    Authors: Caiyun Zhang, Zhiguo Leng, Yinfeng Wang, Lang Ran, Xia Qin, Huan Xin, Xiaotong Xu, Guilong Zhang and Zhaowei Xu
    Citation: Journal of Nanobiotechnology 2022 20:264
  22. A balanced endogenous level of bioavailable nitric oxide (NO) plays a key role in maintaining cardiovascular homeostasis. The bioactive NO level in the cardiomyocytes was much reduced during sepsis. However, i...

    Authors: Minzhi Ouyang, Xiangnan Ouyang, Zefang Peng, Minghui Liu, Ganqiong Xu, Zhen Zou, Ming Zhang and Quanliang Shang
    Citation: Journal of Nanobiotechnology 2022 20:263
  23. Interest in nanomaterials and especially nanoparticles has exploded in the past decades primarily due to their novel or enhanced physical and chemical properties compared to bulk material. These extraordinary ...

    Authors: Nadeem Joudeh and Dirk Linke
    Citation: Journal of Nanobiotechnology 2022 20:262
  24. Adoptive cell therapy (ACT) was one of the most promising anti-tumor modalities that has been confirmed to be especially effective in treating hematological malignancies. However, the clinical efficacy of ACT ...

    Authors: Zhenyu Luo, Lihua Luo, Yichao Lu, Chunqi Zhu, Bing Qin, Mengshi Jiang, Xiang Li, Yingying Shi, Junlei Zhang, Yu Liu, Xinyu Shan, Hang Yin, Guannan Guan, Yongzhong Du, Ningtao Cheng and Jian You
    Citation: Journal of Nanobiotechnology 2022 20:261
  25. Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), seriously threatens human life and health. The correct folding and polymerization of the receptor-bi...

    Authors: Zhongqian Yang, Liangqun Hua, Mengli Yang, Weiran Li, Zhaoling Ren, Xiao Zheng, Haoqian Chen, Qiong Long, Hongmei Bai, Weiwei Huang and Yanbing Ma
    Citation: Journal of Nanobiotechnology 2022 20:260
  26. Patients with diabetic foot ulcers usually suffer from inefficient epithelisation and angiogenesis accompanied by chronic wound healing. Diabetic foot ulcers remain a major challenge in clinical medicine; howe...

    Authors: Pei Wang, Yun Wang, Yang Yi, Yan Gong, Haoran Ji, Yuci Gan, Fei Xie, Jinchen Fan and Xiansong Wang
    Citation: Journal of Nanobiotechnology 2022 20:259
  27. Cisplatin, the alkylating agent of platinum(II) (Pt(II)), is the most common antitumor drug in clinic; however, it has many side effects, therefore it is higly desired to develop low toxicity platinum(IV) (Pt(...

    Authors: Xing Li, Lingpu Zhang, Tuo Li, Shumu Li, Wenjing Wu, Lingyu Zhao, Peng Xie, Jinqi Yang, Peipei Li, Yangyang Zhang, Haihua Xiao, Yingjie Yu and Zhenwen Zhao
    Citation: Journal of Nanobiotechnology 2022 20:258
  28. Ischemic stroke is one of the main causes of death and disability in the world. The treatment for ischemic stroke is to restore blood perfusion as soon as possible. However, when ischemic brain tissue is re-pe...

    Authors: Daozhou Liu, Qifeng Ji, Ying Cheng, Miao Liu, Bangle Zhang, Qibing Mei, Menglei Huan and Siyuan Zhou
    Citation: Journal of Nanobiotechnology 2022 20:256
  29. Engineering the surface of materials with desired multifunctionalities is an effective way to fight against multiple adverse factors during tissue repair process. Recently, metal-polyphenol networks (MPNs) hav...

    Authors: Xinxiu Cheng, Yaxin Zhu, Sicheng Tang, Ruofei Lu, Xiaoqiang Zhang, Na Li and Xingjie Zan
    Citation: Journal of Nanobiotechnology 2022 20:255
  30. Nano-priming is an innovative seed priming technology that helps to improve seed germination, seed growth, and yield by providing resistance to various stresses in plants. Nano-priming is a considerably more e...

    Authors: Shivraj Hariram Nile, Muthu Thiruvengadam, Yao Wang, Ramkumar Samynathan, Mohammad Ali Shariati, Maksim Rebezov, Arti Nile, Meihong Sun, Baskar Venkidasamy, Jianbo Xiao and Guoyin Kai
    Citation: Journal of Nanobiotechnology 2022 20:254
  31. Methotrexate (MTX) has been highlighted for Rheumatoid arthritis (RA) treatment, however, MTX does not accumulate well at inflamed sites, and long-term administration in high doses leads to severe side effects...

    Authors: Yao Wang, Ming Jia, Xiu Zheng, Chenglong Wang, Yun Zhou, Hong Pan, Yan Liu, Ji Lu, Zhiqiang Mei and Chunhong Li
    Citation: Journal of Nanobiotechnology 2022 20:253
  32. Extracellular vesicles (EVs) are promising drug carriers of photosensitizers for photodynamic therapy (PDT) in cancer treatment, due to their ability to circulate in blood and enter cells efficiently. The ther...

    Authors: Ruben V. Huis in ‘t Veld, Pablo Lara, Martine J. Jager, Roman I. Koning, Ferry Ossendorp and Luis J. Cruz
    Citation: Journal of Nanobiotechnology 2022 20:252
  33. At present, patients with myocardial infarction remain an increased risk for myocardial ischemia/reperfusion injury (MI/RI). There lacks effectively method to treat MI/RI in clinic. For the treatment of MI/RI,...

    Authors: Fangyuan Li, Daozhou Liu, Miao Liu, Qifeng Ji, Bangle Zhang, Qibing Mei, Ying Cheng and Siyuan Zhou
    Citation: Journal of Nanobiotechnology 2022 20:251
  34. Applying traditional fluorescence navigation technologies in hepatocellular carcinoma is severely restricted by high false-positive rates, variable tumor differentiation, and unstable fluorescence performance.

    Authors: Pan He, Yongfu Xiong, Jinfa Ye, Biaoqi Chen, Hongwei Cheng, Hao Liu, Yating Zheng, Chengchao Chu, Jingsong Mao, Aizheng Chen, Yang Zhang, Jingdong Li, Jie Tian and Gang Liu
    Citation: Journal of Nanobiotechnology 2022 20:250
  35. Our previous studies suggest that human fat extract (FE) contains a variety of angiogenic factors and may provide an alternative treatment option for stroke. However, the therapeutic effect is largely limited ...

    Authors: Cheng Wang, Xuewei Yang, Yixu Jiang, Lin Qi, Deli Zhuge, Tongtong Xu, Yiyan Guo, Mingwu Deng, Wenjie Zhang, Dongyan Tian, Qingqing Yin, Li Li, Zhijun Zhang, Yongting Wang, Guo-Yuan Yang, Yijie Chen…
    Citation: Journal of Nanobiotechnology 2022 20:249
  36. Exosomes are nanoscale monolayer membrane vesicles that are actively endogenously secreted by mammalian cells. Currently, multifunctional exosomes with tumor-targeted imaging and therapeutic potential have aro...

    Authors: Congcong Wang, Ning Li, Yutian Li, Shasha Hou, Wenxin Zhang, Zhaowei Meng, Shen Wang, Qiang Jia, Jian Tan, Renfei Wang and Ruiguo Zhang
    Citation: Journal of Nanobiotechnology 2022 20:247
  37. Liquid metal (LM) can be integrated into microfluidic channel, bringing new functionalities of microfluidics and opening a new window for soft microfluidic electronics, due to the superior advantages of the co...

    Authors: Yang Zhang, Haowei Duan, Guoqiang Li, Maoyu Peng, Xing Ma, Ming Li and Sheng Yan
    Citation: Journal of Nanobiotechnology 2022 20:246
  38. Immunotherapies have been gaining attention for the prevention of cancer recurrence and metastasis. Cancer immunotherapy can induce memory cells to target cancer-specific antigens and, thus, selectively kill c...

    Authors: Juyoung Hwang, Eun-Koung An, Wei Zhang, Hyo Jeong Kim, Youngho Eom and Jun-O. Jin
    Citation: Journal of Nanobiotechnology 2022 20:245
  39. The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustain...

    Authors: Yubo Liu, Xiaohong Chen, Yuhang Gao, Deng-Guang Yu and Ping Liu
    Citation: Journal of Nanobiotechnology 2022 20:244
  40. Triple-negative breast cancer (TNBC) is more prone to distant metastasis and visceral recurrence in comparison to other breast cancer subtypes, and is related to dismal prognosis. Nevertheless, TNBC has an und...

    Authors: Fuqiang Shao, Zhidi Pan, Yu Long, Ziyang Zhu, Kun Wang, Hao Ji, Ke Zhu, Wenyu Song, Yangmeihui Song, Xiangming Song, Yongkang Gai, Qingyao Liu, Chunxia Qin, Dawei Jiang, Jianwei Zhu and Xiaoli Lan
    Citation: Journal of Nanobiotechnology 2022 20:243

    The Correction to this article has been published in Journal of Nanobiotechnology 2023 21:345

  41. The exchange of mitochondria reportedly plays an important role in cell–cell communication in the central nervous system (CNS). The transfer of fragmented and dysfunctional astrocytic mitochondria into neurons...

    Authors: Wei Liu, Chang Su, Yao Qi, Jia Liang, Liang Zhao and Yijie Shi
    Citation: Journal of Nanobiotechnology 2022 20:242
  42. Periprosthetic osteolysis (PPO) triggered by wear particles is the most severe complication of total joint replacement (TJR) surgeries, representing the major cause of implant failure, which is public health c...

    Authors: Wei Wang, Xiaolong Liang, Xin Liu, Jiaxiang Bai, Wei Zhang, Wenming Li, Tianhao Wang, Meng Li, Zerui Wu, Liang Chen, Huilin Yang, Ye Gu, Yunxia Tao, Jun Zhou, Huaiyu Wang and Dechun Geng
    Citation: Journal of Nanobiotechnology 2022 20:241
  43. Postoperative chemotherapy for gastric cancer often causes multidrug resistance (MDR), which has serious consequences for therapeutic effects. Individualized treatment based on accurate monitoring of MDR will ...

    Authors: Hanrui Li, Xiaoxia Cai, Tong Yi, Yun Zeng, Jingwen Ma, Lei Li, Liaojun Pang, Na Li, Hao Hu and Yonghua Zhan
    Citation: Journal of Nanobiotechnology 2022 20:240
  44. High-quality cutaneous wound healing is associated with rapid wound closure and a comfortable healing process. Currently, exosomes derived from mesenchymal stem cells displayed a prominent therapeutic effect o...

    Authors: Yunyi Xie, Le Yu, Zhilan Cheng, Yingying Peng, Zeyuan Cao, Beichen Chen, Yihong Duan and Yan Wang
    Citation: Journal of Nanobiotechnology 2022 20:239
  45. Nanomedicines (NMs) have emerged as an efficient approach for developing novel treatment strategies against a variety of diseases. Over the past few decades, NM formulations have received great attention, and ...

    Authors: Ruslan G. Tuguntaev, Abid Hussain, Chenxing Fu, Haoting Chen, Ying Tao, Yan Huang, Lu Liu, Xing-Jie Liang and Weisheng Guo
    Citation: Journal of Nanobiotechnology 2022 20:236
  46. MXenes with interesting optical and electrical properties have been attractive in biomedical applications such as antibacterial and anticancer agents, but their low photogeneration efficiency of reactive oxyge...

    Authors: Ya-Ju Hsu, Amit Nain, Yu-Feng Lin, Yu-Ting Tseng, Yu-Jia Li, Arumugam Sangili, Pavitra Srivastava, Hui-Ling Yu, Yu-Fen Huang, Chih-Ching Huang and Huan-Tsung Chang
    Citation: Journal of Nanobiotechnology 2022 20:235

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