Articles

pH-sensitive dual drug loaded janus nanoparticles by oral delivery for multimodal analgesia

Based on the concept of “multimodal analgesia”, a novel dual drug delivery system was designed to achieve synergistic analgesia between najanajaatra venom protein (αCT) and resveratrol (Res). In order to meet ...

Authors: Lin Liu, Wendong Yao, Xiaowei Xie, Jianqing Gao and Xiaoyang Lu

Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring

Pregnancy exposure to titanium dioxide nanoparticles (TiO₂NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO₂NPs on the neurodev...

Authors: Junhao Su, Xinhao Duan, Yu Qiu, Lixiao Zhou, Hongyang Zhang, Min Gao, Yijun Liu, Zhen Zou, Jingfu Qiu and Chengzhi Chen

Correction to: Stem cell membrane-coated isotretinoin for acne treatment

Authors: Shiyi Wang, Rihua Jiang, Tianqi Meng, Fuqiang Zhang, Jing Li, Yongri Jin, JeungHoon Lee, Mingji Zhu and Jinlan Jiang

Elaboration on the architecture of pH-sensitive surface charge-adaptive micelles with enhanced penetration and bactericidal activity in biofilms

Biofilm formation is one of the main reasons for persistent bacterial infections. Recently, pH-sensitive copolymers have fascinated incredible attention to tackle biofilm-related infections. However, the prope...

Authors: Rong Guo, Keke Li, Baocheng Tian, Changrong Wang, Xiangjun Chen, Xinyu Jiang, Huayu He and Wei Hong

CRISPR/Cas9 nanoeditor of double knockout large fragments of E6 and E7 oncogenes for reversing drugs resistance in cervical cancer

Drug resistance of tumor cells is always a headache problem in clinical treatment. In order to combat chemotherapy-resistance in cervical cancer and improve treatment effect, we design a CRISPR/Cas9 nanoeditor...

Authors: Xianhuang Li, Mingming Guo, Bei Hou, Bin Zheng, Zhiyun Wang, Mengqian Huang, Yanan Xu, Jin Chang and Tao Wang

Improving the ameliorative effects of berberine and curcumin combination via dextran-coated bilosomes on non-alcohol fatty liver disease in mice

The combination of berberine (BER) and curcumin (CUR) has been verified with ameliorative effects on non-alcohol fatty liver disease (NAFLD). However, discrepant bioavailability and biodistribution of BER and ...

Authors: Yi Chen, Zhaohui Jiang, Jinzhuan Xu, Jiyuan Zhang, Runbin Sun, Jia Zhou, Yuan Lu, Zipeng Gong, Jing Huang, Xiangchun Shen, Qianming Du and Jianqing Peng

Platelet membrane-camouflaged silver metal-organic framework drug system against infections caused by methicillin-resistant Staphylococcus aureus

Due to the intelligent survival strategy and self-preservation of methicillin-resistant Staphylococcus aureus (MRSA), many antibiotics are ineffective in treating MRSA infections. Nano-drug delivery systems have ...

Authors: Rong Huang, Guang-Qing Cai, Jian Li, Xi-Sheng Li, Hai-Ting Liu, Xue-Ling Shang, Jian-Dang Zhou, Xin-Min Nie and Rong Gui

Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair

One of the greatest challenges for tissue-engineered bone is the low survival rate of locally grafted cells. The cell homing technology can effectively increase the number of these grafted cells, therefore, en...

Authors: Long Chen, Wei Luo, Yuanzheng Wang, Xiongbo Song, Senlei Li, Jun Wu and Li Sun

A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery

The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as dr...

Authors: Jianmin Xiao, Miao Yan, Ke Zhou, Hui Chen, Zhaowei Xu, Yuehao Gan, Biao Hong, Geng Tian, Junchao Qian, Guilong Zhang and Zhengyan Wu

MiR-144-5p, an exosomal miRNA from bone marrow-derived macrophage in type 2 diabetes, impairs bone fracture healing via targeting Smad1

Patients with diabetes have an increased risk of nonunion and delayed union of fractures. Macrophages have been shown as a key player in diabetic complications. However, it remains obscure how diabetic milieu ...

Authors: Dong Zhang, Yifan Wu, Zonghuan Li, Hairen Chen, Siyuan Huang, Chao Jian and Aixi Yu

Multi-function PtCo nanozymes/CdS nanocrystals@graphene oxide luminophores and K₂S₂O₈/H₂O₂ coreactants-based dual amplified electrochemiluminescence immunosensor for ultrasensitive detection of anti-myeloperoxidase antibody

Anti-myeloperoxidase antibody (anti-MPO) is an important biomarker for anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs). However, the complicated operation procedures and insufficient s...

Authors: Wei Yang, Zheng Zhou, Haiping Wu, Changjin Liu, Bo Shen, Shijia Ding and Yonglie Zhou

Curcumin loaded sub-30 nm targeting therapeutic lipid nanoparticles for synergistically blocking nasopharyngeal cancer growth and metastasis

Systemic chemotherapy is still the primary treatment for advanced-stage nasopharyngeal carcinoma (NPC), but only limited therapeutic success has been achieved in the past decade because of drug resistance and ...

Authors: Haiming Luo, Lisen Lu, Ni Liu, Qingqing Li, Xiaoquan Yang and Zhihong Zhang

Intratumoral administration of astatine-211-labeled gold nanoparticle for alpha therapy

²¹¹At is a high-energy α-ray emitter with a relatively short half-life and a high cytotoxicity for cancer cells. Its dispersion can be imaged using clinical scanners, and it can be produced in cyclotrons without ...

Authors: Hiroki Kato, Xuhao Huang, Yuichiro Kadonaga, Daisuke Katayama, Kazuhiro Ooe, Atsushi Shimoyama, Kazuya Kabayama, Atsushi Toyoshima, Atsushi Shinohara, Jun Hatazawa and Koichi Fukase

Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(−/−) mice

Rupture of atherosclerotic plaque can cause acute malignant heart and cerebrovascular events, such as acute coronary heart disease, stroke and so on, which seriously threaten the safety of human life and prope...

Authors: Qi Wang, Yong Wang, Siwen Liu, Xuan Sha, Xiaoxi Song, Yue Dai, Mingming Zhao, Lulu Cai, Kai Xu and Jingjing Li

Amplification of oxidative stress with lycorine and gold-based nanocomposites for synergistic cascade cancer therapy

Despite advances of surgery and neoadjuvant chemotherapy during the past few decades, the therapeutic efficacy of current therapeutic protocol for osteosarcoma (OS) is still seriously compromised by multi-drug...

Authors: Hongzhi Hu, Wenbo Yang, Zihui Liang, Zezhu Zhou, Qingcheng Song, Weijian Liu, Xiangtian Deng, Jian Zhu, Xin Xing, Binglong Zhong, Baichuan Wang, Shangyu Wang, Zengwu Shao and Yingze Zhang

Chiral nanomaterials for tumor therapy: autophagy, apoptosis, and photothermal ablation

Chirality is a fundamental characteristic of natural molecules and a crucial factor in the biochemical reactions of living cells and organisms. Recently, researchers have successfully introduced chiral molecul...

Authors: Zaihui Peng, Long Yuan, Juncheng XuHong, Hao Tian, Yi Zhang, Jun Deng and Xiaowei Qi

Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

Chemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollab...

Authors: Junfeng Huang, Zhourui Xu, Yihang jiang, Wing-cheung Law, Biqin Dong, Xierong Zeng, Mingze Ma, Gaixia Xu, Jizhao Zou and Chengbin Yang

Growth rate-dependent flexural rigidity of microtubules influences pattern formation in collective motion

Microtubules (MTs) are highly dynamic tubular cytoskeleton filaments that are essential for cellular morphology and intracellular transport. In vivo, the flexural rigidity of MTs can be dynamically regulated d...

Authors: Hang Zhou, Naoto Isozaki, Kazuya Fujimoto and Ryuji Yokokawa

Correction to: Central composite design for the development of carvedilol-loaded transdermal ethosomal hydrogel for extended and enhanced anti-hypertensive effect

Authors: Padmanabha Rao Amarachinta, Garima Sharma, Noufel Samed, Ananda Kumar Chettupalli, Madhusudhan Alle and Jin-Chul Kim

Aptamer-based biosensors for the diagnosis of sepsis

Sepsis, the syndrome of infection complicated by acute organ dysfunction, is a serious and growing global problem, which not only leads to enormous economic losses but also becomes one of the leading causes of...

Authors: Lubin Liu, Zeyu Han, Fei An, Xuening Gong, Chenguang Zhao, Weiping Zheng, Li Mei and Qihui Zhou

Correction to: Ultrathin gold nanowires to enhance radiation therapy

Authors: Lin Bai, Fangchao Jiang, Renjie Wang, Chaebin Lee, Hui Wang, Weizhong Zhang, Wen Jiang, Dandan Li, Bin Ji, Zibo Li, Shi Gao, Jin Xie and Qingjie Ma

Injectable stress relaxation gelatin-based hydrogels with positive surface charge for adsorption of aggrecan and facile cartilage tissue regeneration

Cartilage injury and pathological degeneration are reported in millions of patients globally. Cartilages such as articular hyaline cartilage are characterized by poor self-regeneration ability due to lack of v...

Authors: Kai-Yang Wang, Xiang-Yun Jin, Yu-Hui Ma, Wei-Jie Cai, Wei-Yuan Xiao, Zhi-Wei Li, Xin Qi and Jian Ding

Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such a...

Authors: Pengkai Wu, Xing Jiang, Shuai Yin, Ying Yang, Tianqing Liu and Kaikai Wang

Radiopharmaceutical and Eu³⁺ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery

Cerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limi...

Authors: Xiaojing Shi, Caiguang Cao, Zeyu Zhang, Jie Tian and Zhenhua Hu

Graphene-based nanomaterials for breast cancer treatment: promising therapeutic strategies

Breast cancer is the most common malignancy in women, and its incidence increases annually. Traditional therapies have several side effects, leading to the urgent need to explore new smart drug-delivery system...

Authors: Guangman Cui, Junrong Wu, Jiaying Lin, Wenjing Liu, Peixian Chen, Meng Yu, Dan Zhou and Guangyu Yao

Near infrared light fluorescence imaging-guided biomimetic nanoparticles of extracellular vesicles deliver indocyanine green and paclitaxel for hyperthermia combined with chemotherapy against glioma

We investigated the therapeutic effect of targeting extracellular vesicles (EVs) loaded with indocyanine green (ICG) and paclitaxel (PTX) on glioma.

Authors: Meng Wang, Chen-Yan Lv, Shu-Ang Li, Jun-Kuan Wang, Wen-Zheng Luo, Pei-Chao Zhao, Xue-You Liu, Ze-Ming Wang, Yang Jiao, Hong-Wei Sun, Yi Zhao and Peng Zhang

Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis

The therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar paracrine functions of stem cells and overcome the limitations of stem c...

Authors: Di Wu, Xiao Chang, Jingjing Tian, Lin Kang, Yuanhao Wu, Jieying Liu, Xiangdong Wu, Yue Huang, Bo Gao, Hai Wang, Guixing Qiu and Zhihong Wu

LDL mediated delivery of Paclitaxel and MRI imaging probes for personalized medicine applications

The combination of imaging and therapeutic agents in the same smart nanoparticle is a promising option to perform a minimally invasive imaging guided therapy. In this study, Low density lipoproteins (LDL), one...

Authors: Sahar Rakhshan, Diego Alberti, Rachele Stefania, Valeria Bitonto and Simonetta Geninatti Crich

Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli

Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the a...

Authors: Xin Huang, Donghua Huang, Ting Zhu, Xiaohua Yu, Kaicheng Xu, Hengyuan Li, Hao Qu, Zhiyuan Zhou, Kui Cheng, Wenjian Wen and Zhaoming Ye

Fe₃O₄@Pt nanoparticles to enable combinational electrodynamic/chemodynamic therapy

Electrodynamic therapy (EDT) has recently emerged as a potential external field responsive approach for tumor treatment. While it presents a number of clear superiorities, EDT inherits the intrinsic challenges...

Authors: Tong Chen, Qiang Chu, Mengyang Li, Gaorong Han and Xiang Li

Amphiphilic branched polymer-nitroxides conjugate as a nanoscale agent for potential magnetic resonance imaging of multiple objects in vivo

In order to address the potential toxicity of metal-based magnetic resonance imaging (MRI) contrast agents (CAs), a concept of non-metallic MRI CAs has emerged. Currently, paramagnetic nitroxides (such as (2,2...

Authors: Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong and Kui Luo

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

Photodynamic therapy (PDT), a typical reactive oxygen species (ROS)-dependent treatment with high controllability, has emerged as an alternative cancer therapy modality but its therapeutic efficacy is still un...

Authors: Xiaoyan Wang, Ming Wu, Xiaolong Zhang, Feida Li, Yongyi Zeng, Xinyi Lin, Xiaolong Liu and Jingfeng Liu

Synthesis of iridium-based nanocomposite with catalase activity for cancer phototherapy

The combination of photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted attention due to its enhanced tumor therapy effect. This study proposes a novel nanoenzyme-based theranostic nanoplatf...

Authors: Hang Wu, Qi Jiang, Keyi Luo, Chunping Zhu, Mengmeng Xie, Shige Wang, Zhewei Fei and Jiulong Zhao

Hypoxia adipose stem cell-derived exosomes promote high-quality healing of diabetic wound involves activation of PI3K/Akt pathways

Refractory diabetic wounds can cause persistent inflammation and delayed healing due to hypoxia. Currently, no optimal solution is available. Exosomes of adipose stem cells (ADSCs-exo) may promote skin wound h...

Authors: Jie Wang, Hao Wu, Yixuan Peng, Yue Zhao, Youyou Qin, Yingbo Zhang and Zhibo Xiao

Designing highly stable ferrous selenide-black phosphorus nanosheets heteronanostructure via P-Se bond for MRI-guided photothermal therapy

The design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is i...

Authors: Xuanru Deng, Hongxing Liu, Yuan Xu, Leung Chan, Jun Xie, Zushuang Xiong, Zheng Tang, Fang Yang and Tianfeng Chen

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Recent studies have demonstrated that multidrug resistance (MDR) is a critical factor in the low efficacy of cancer chemotherapy. The main mechanism of MDR arises from the overexpression of P-glycoprotein (P-g...

Authors: Weixi Jiang, Lei Su, Meng Ao, Xun Guo, Chen Cheng, Yuanli Luo, Zhuoyan Xie, Xingyue Wang, Junrui Wang, Shuling Liu, Yang Cao, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou and Jianli Ren

Comparative colloidal stability, antitumor efficacy, and immunosuppressive effect of commercial paclitaxel nanoformulations

Standard chemotherapy with taxanes, such as paclitaxel (PTX), remains the mainstay of systemic treatment of triple-negative breast cancer. Nanotechnology-based formulations have gradually replaced PTX injectio...

Authors: Jun Ye, Renjie Li, Yanfang Yang, Wujun Dong, Yujie Wang, Hongliang Wang, Tong Sun, Lin Li, Qiqi Shen, Caiyun Qin, Xiaoyan Xu, Hengfeng Liao, Yiqun Jin, Xuejun Xia and Yuling Liu

Multi-responsive nanofibers composite gel for local drug delivery to inhibit recurrence of glioma after operation

The postoperative recurrence of malignant gliomas has presented a clinical conundrum currently. Worse, there is no standard treatment for these recurrent tumours. Therefore, novel promising methods of clinical...

Authors: Yufu Zhu, Jun Jia, Gang Zhao, Xuyang Huang, Lansheng Wang, Yongkang Zhang, Long Zhang, Naveena Konduru, Jun Xie, Rutong Yu and Hongmei Liu

Cartilage-targeting poly(ethylene glycol) (PEG)-formononetin (FMN) nanodrug for the treatment of osteoarthritis

Intra-articular (IA) injection is an efficient treatment for osteoarthritis, which will minimize systemic side effects. However, the joint experiences rapid clearance of therapeutics after intra-articular inje...

Authors: Wei Xiong, Qiumei Lan, Xiaonan Liang, Jinmin Zhao, Hanji Huang, Yanting Zhan, Zainen Qin, Xianfang Jiang and Li Zheng

RGD-modified multifunctional nanoparticles encapsulating salvianolic acid A for targeted treatment of choroidal neovascularization

The development of alternative anti-angiogenesis therapy for choroidal neovascularization (CNV) remains a great challenge. Nanoparticle systems have emerged as a new form of drug delivery in ocular diseases. H...

Authors: Junxiu Zhang, Jingyi Zhu, Lingzhou Zhao, Ke Mao, Qing Gu, Dongli Li, Jinhua Zhao and Xingwei Wu

Broadening the biocompatibility of gold nanorods from rat to Macaca fascicularis: advancing clinical potential

The biomedical field has used gold nanorods (GNRs) for decades; however, clinical trials and translation is limited except gold nanoshells. The preparation of gold nanoshells is more complex than that of polye...

Authors: Jinfeng Liao, Taorang Tian, Sirong Shi, Xueping Xie, Shuanglin Peng, Ying Zhu, Jingang Xiao and Yunfeng Lin

Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis

Extracellular vesicles (EVs) secreted by mesenchymal stem cells (MSCs) may play a vital role in a variety of biological processes, including cartilage regeneration. However, few studies reported their potentia...

Authors: Shenglong Li, Jie Liu, Siyu Liu, Weijie Jiao and Xiaohong Wang

Understanding the impact of more realistic low-dose, prolonged engineered nanomaterial exposure on genotoxicity using 3D models of the human liver

With the continued integration of engineered nanomaterials (ENMs) into everyday applications, it is important to understand their potential for inducing adverse human health effects. However, standard in vitro...

Authors: Samantha V. Llewellyn, Gillian E. Conway, Ilaria Zanoni, Amalie Kofoed Jørgensen, Ume-Kulsoom Shah, Didem Ag Seleci, Johannes G. Keller, Jeong Won Kim, Wendel Wohlleben, Keld Alstrup Jensen, Anna Costa, Gareth J. S. Jenkins, Martin J. D. Clift and Shareen H. Doak

Chemodynamic nanomaterials for cancer theranostics

It is of utmost urgency to achieve effective and safe anticancer treatment with the increasing mortality rate of cancer. Novel anticancer drugs and strategies need to be designed for enhanced therapeutic effic...

Authors: Jingqi Xin, Caiting Deng, Omer Aras, Mengjiao Zhou, Chunsheng Wu and Feifei An

Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications

Diabetes complications are the leading cause of mortality in diabetic patients. The common complications are decline in antioxidant capacity and the onset of micro-inflammation syndrome. At present, glucose-re...

Authors: Xi Zhao, Anhua Shi, Qiong Ma, Xueyan Yan, Ligong Bian, Pengyue Zhang and Junzi Wu

LED control of gene expression in a nanobiosystem composed of metallic nanoparticles and a genetically modified E. coli strain

Within the last decade, genetic engineering and synthetic biology have revolutionized society´s ability to mass-produce complex biological products within genetically-modified microorganisms containing elegant...

Authors: Hossein Alishah Aratboni, Nahid Rafiei, Larousse Khosravi Khorashad, Albert Isaac Lerma-Escalera, Francisco de Jesús Balderas-Cisneros, Zhaowei Liu, Abbas Alemzadeh, Sadasivan Shaji and José Ruben Morones-Ramírez

Fe-doped chrysotile nanotubes containing siRNAs to silence SPAG5 to treat bladder cancer

For certain human cancers, sperm associated antigen 5 (SPAG5) exerts important functions for their development and progression. However, whether RNA interference (RNAi) targeting SPAG5 has antitumor effects has n...

Authors: Jianye Liu, Yi Zhang, Hongliang Zeng, Long Wang, Qun Zhang, Pei Wu, Xiaoming Liu, Hongyi Xie, Wei Xiang, Biao Liu, Jiahao Liu, Xuewen Liu, Jianfei Xie, Jin Tang, Zhi Long, Leye He…

Novel CD44-targeting and pH/redox-dual-stimuli-responsive core–shell nanoparticles loading triptolide combats breast cancer growth and lung metastasis

The toxicity and inefficient delivery of triptolide (TPL) in tumor therapy have greatly limited the clinical application. Thus, we fabricated a CD44-targeting and tumor microenvironment pH/redox-sensitive nano...

Authors: Jinfeng Shi, Yali Ren, Jiaqi Ma, Xi Luo, Jiaxin Li, Yihan Wu, Huan Gu, Chaomei Fu, Zhixing Cao and Jinming Zhang

Ex vivo and in vivo fluorescence detection and imaging of adenosine triphosphate

Ex vivo and in vivo detection and imaging of adenosine triphosphate (ATP) is critically important for the diagnosis and treatment of diseases, which still remains challenges up to present.

Authors: Binbin Chu, Ajun Wang, Liang Cheng, Runzhi Chen, Huayi Shi, Bin Song, Fenglin Dong, Houyu Wang and Yao He

Use of magnetic nanotrap particles in capturing Yersinia pestis virulence factors, nucleic acids and bacteria

Many pathogens, including Yersinia pestis, cannot be consistently and reliably cultured from blood. New approaches are needed to facilitate the detection of proteins, nucleic acid and microorganisms in whole bloo...

Authors: Alexandra N. Ii, Shih-Chao Lin, Benjamin Lepene, Weidong Zhou, Kylene Kehn-Hall and Monique L. van Hoek