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  1. Glucocorticoids (GCs) overuse is associated with decreased bone mass and osseous vasculature destruction, leading to severe osteoporosis. Platelet lysates (PL) as a pool of growth factors (GFs) were widely use...

    Authors: Gang Zheng, Hai-Wei Ma, Guang-Heng Xiang, Gao-Lu He, Han-Chen Cai, Zi-Han Dai, Yan-Lin Chen, Yan Lin, Hua-Zi Xu, Wen-Fei Ni, Cong Xu, Hai-Xiao Liu and Xiang-Yang Wang
    Citation: Journal of Nanobiotechnology 2022 20:220
  2. In the field of nanoscience there is an increasing interest to follow dynamics of nanoparticles (NP) in cells with an emphasis on endo-lysosomal pathways and long-term NP fate. During our research on this topi...

    Authors: Aura Maria Moreno-Echeverri, Eva Susnik, Dimitri Vanhecke, Patricia Taladriz-Blanco, Sandor Balog, Alke Petri-Fink and Barbara Rothen-Rutishauser
    Citation: Journal of Nanobiotechnology 2022 20:464
  3. Exosome mediated mRNA delivery is a promising strategy for the treatment of multiple diseases. However, the low yield of exosomes is a bottleneck for clinical translation. In this study, we boosted exosome pro...

    Authors: Rongxin Zhang, Te Bu, Ruidan Cao, Zhelong Li, Chen Wang, Bing Huang, Mengying Wei, Lijun Yuan and Guodong Yang
    Citation: Journal of Nanobiotechnology 2022 20:463
  4. Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone formation, this pathway is controlled by ...

    Authors: Patricia García-García, Ricardo Reyes, Daniel García-Sánchez, Flor María Pérez-Campo, José Carlos Rodríguez-Rey, Carmen Évora, Patricia Díaz-Rodríguez and Araceli Delgado
    Citation: Journal of Nanobiotechnology 2022 20:462
  5. Traumatic peripheral nerve injury (TPNI) is a major medical problem with no universally accepted pharmacologic treatment. We hypothesized that encapsulation of pro-angiogenic erythropoietin (EPO) in amphiphili...

    Authors: Kristen M. Manto, Prem Kumar Govindappa, Brandon Martinazzi, Aijie Han, John P. Hegarty, Zachary Koroneos, M. A. Hassan Talukder and John C. Elfar
    Citation: Journal of Nanobiotechnology 2022 20:461
  6. Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons and regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with elect...

    Authors: Jiaying Cai, Hui Zhang, Yangnan Hu, Zhichun Huang, Yan Wang, Yu Xia, Xiaoyan Chen, Jiamin Guo, Hong Cheng, Lin Xia, Weicheng Lu, Chen Zhang, Jingdun Xie, Huan Wang and Renjie Chai
    Citation: Journal of Nanobiotechnology 2022 20:460
  7. Exfoliation syndrome presents as an accumulation of insoluble fibrillar aggregates that commonly correlates with age and causes ocular complications, most notably open-angle glaucoma. Despite advances in under...

    Authors: Mehdi Ghaffari Sharaf, Kosala D. Waduthanthri, Andrew Crichton, Karim F. Damji and Larry D. Unsworth
    Citation: Journal of Nanobiotechnology 2022 20:459
  8. Due to the urgent demand for more anti-cancer methods, the new applications of metal ions in cancer have attracted increasing attention. Especially the three kinds of the new mode of cell death, including ferr...

    Authors: Han Hu, Qi Xu, Zhimin Mo, Xiaoxi Hu, Qianyuan He, Zhanjie Zhang and Zushun Xu
    Citation: Journal of Nanobiotechnology 2022 20:457
  9. MicroRNAs (miRNAs) are small non-coding RNAs with ~ 22 nucleotides, playing important roles in the post-transcriptional regulation of gene expression. The expression profiles of many miRNAs are closely related...

    Authors: Ying Gan, Mingxing Zhou, Huiqiang Ma, Jiameng Gong, Shan-Yu Fung, Xian Huang and Hong Yang
    Citation: Journal of Nanobiotechnology 2022 20:456
  10. Phellinus linteus (PL), which is a typical medicinal fungus, has been shown to have antitumor and anti-inflammatory activities. However, studies on the effect of anti-photoaging are limited. Studies have shown th...

    Authors: Jingxia Han, Ting Wu, Jing Jin, Zhiyang Li, Wenjun Cheng, Xintong Dai, Kai Yang, Heng Zhang, Zhiyuan Zhang, Haohao Zhang, Rong Fan, Shaoting Zheng, Haoyang Liu, Yinan Li, Huan Zhao, Cheng Yao…
    Citation: Journal of Nanobiotechnology 2022 20:455
  11. Resolvin D1 (RvD1) has been shown to provide effective protection against ischemia–reperfusion injury in multiple vital organs such as the heart, brain, kidney. However, the clinical translational potential of...

    Authors: Xueyi Weng, Haipeng Tan, Zheyong Huang, Jing Chen, Ning Zhang, Qiaozi Wang, Qiyu Li, Jinfeng Gao, Dili Sun, Wusiman Yakufu, Zhengmin Wang, Weiyan Li, Guangrui Zhu, Zhiqing Pang, Yanan Song, Juying Qian…
    Citation: Journal of Nanobiotechnology 2022 20:454
  12. Pancreatic cancer remains among the most prevalent and aggressive forms of cancer. While immunotherapeutic treatment strategies have shown some promise in affected patients, the benefits of these interventions...

    Authors: Libin Chen, Wang Xue, Jing Cao, Shengmin Zhang, Yiqing Zeng, Ling Ma, Xuechen Qian, Qing Wen, Yurong Hong, Zhan Shi and Youfeng Xu
    Citation: Journal of Nanobiotechnology 2022 20:453
  13. Ossification of the posterior longitudinal ligament (OPLL) is a disabling disease whose pathogenesis is still unclear, and there are no effective cures or prevention methods. Exosomal miRNA plays an important ...

    Authors: Yifan Tang, Yanqing Sun, Junkai Zeng, Bo Yuan, Yin Zhao, Xiangwu Geng, Lianshun Jia, Shengyuan Zhou and Xiongsheng Chen
    Citation: Journal of Nanobiotechnology 2022 20:452
  14. Mesenchymal stem cells (MSC) secrete extracellular vesicles (EV) with a regenerative profile, and an increasing number of studies have focused on the utilization of MSC-EV for therapeutic drug delivery. Howeve...

    Authors: Kyong-Su Park, Markus Bergqvist, Cecilia Lässer and Jan Lötvall
    Citation: Journal of Nanobiotechnology 2022 20:451
  15. Advances in diagnostic imaging have provided unprecedented opportunities to detect diseases at early stages and with high reliability. Diagnostic imaging is also crucial to monitoring the progress or remission...

    Authors: Ahmed Refaat, May Lin Yap, Geoffrey Pietersz, Aidan Patrick Garing Walsh, Johannes Zeller, Blanca del Rosal, Xiaowei Wang and Karlheinz Peter
    Citation: Journal of Nanobiotechnology 2022 20:450
  16. In the frame of radiotherapy treatment of cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve the radiosensitivity of tumors and reduce the damage of...

    Authors: Hao Sun, Hui Cai, Chang Xu, Hezheng Zhai, François Lux, Yi Xie, Li Feng, Liqing Du, Yang Liu, Xiaohui Sun, Qin Wang, Huijuan Song, Ningning He, Manman Zhang, Kaihua Ji, Jinhan Wang…
    Citation: Journal of Nanobiotechnology 2022 20:449
  17. Reactive oxygen species (ROS) at supraphysiological concentration have a determinate role in contributing to immuno-metabolic disorders in the epithelial immune microenvironment (EIME) of psoriatic lesions. Wi...

    Authors: Jiangmei Xu, Hao Chen, Haisheng Qian, Fei Wang and Yunsheng Xu
    Citation: Journal of Nanobiotechnology 2022 20:448
  18. In oral and maxillofacial surgery, flap repair is essential to the quality of postoperative life. Still, thrombosis is fatal for the survival of the flaps. Besides, some postoperative thrombotic diseases, such...

    Authors: Zichen Cao, Xinyu Zhang, Zheng Wei, Chuanhui Song, Huihui Zou, Jianchuan Ran, Hongbo Zhang, Diya Xie, Shengwei Han, Yufeng Wang, Yu Cai and Wei Han
    Citation: Journal of Nanobiotechnology 2022 20:447
  19. Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal cancers worldwide with high mortality, which is mainly due to the lack of reliable biomarkers for PDAC diagnosis/prognosis in the early stages a...

    Authors: Wei Zhang, Douglas H. Campbell, Bradley J. Walsh, Nicolle H. Packer, Dingbin Liu and Yuling Wang
    Citation: Journal of Nanobiotechnology 2022 20:446
  20. Pseudomonas aeruginosa infection is a severe acute suppurative ulcer that engulfs virtually the entire tissue in a short period and leads to devastating destruction. Antibiotic therapy is a common approach for th...

    Authors: Hongwei Wang, Fangying Song, Jing Feng, Xia Qi, Li Ma, Lixin Xie, Weiyun Shi and Qingjun Zhou
    Citation: Journal of Nanobiotechnology 2022 20:445
  21. Tissue engineering scaffolds are essential for repairing bone defects. The use of biomimetic scaffolds for bone tissue engineering has been investigated for decades. To date, the trend in this area has been mo...

    Authors: Yangyufan Wang, Bin Kong, Xiang Chen, Rui Liu, Yuanjin Zhao, Zhuxiao Gu and Qing Jiang
    Citation: Journal of Nanobiotechnology 2022 20:444
  22. The formation of biomolecular condensates via liquid‒liquid phase separation (LLPS) is an advantageous strategy for cells to organize their subcellular compartments for diverse functions. Recent findings sugge...

    Authors: Zhen Xing, Jing Xue, Xindian Ma, Congwei Han, Zhenzhen Wang, Shunhuang Luo, Chunming Wang, Lei Dong and Junfeng Zhang
    Citation: Journal of Nanobiotechnology 2022 20:442
  23. Despite being a promising strategy, current chemotherapy for gastric cancer (GC) is limited due to adverse side effects and poor survival rates. Therefore, new drug-delivery platforms with good biocompatibilit...

    Authors: Rongbo Wang, Keum-yun Ha, Sanjeevram Dhandapani and Yeon-Ju Kim
    Citation: Journal of Nanobiotechnology 2022 20:441
  24. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to COVID-19 and has become a pandemic worldwide with mortality of millions. Nanotechnology can be used to deliver antiviral medicines or other t...

    Authors: Saman Yasamineh, Hesam Ghafouri Kalajahi, Pooneh Yasamineh, Yalda Yazdani, Omid Gholizadeh, Raheleh Tabatabaie, Hamed Afkhami, Fatemeh Davodabadi, Alireza Khanalipour farkhad, Daryoush Pahlevan, Akram Firouzi-Amandi, Kazem Nejati-Koshki and Mehdi Dadashpour
    Citation: Journal of Nanobiotechnology 2022 20:440
  25. Dysbiosis or imbalance of gut microbiota in Alzheimer's disease (AD) affects the production of short-chain fatty acids (SCFAs), whereas exogenous SCFAs supplementation exacerbates brain Aβ burden in APP/PS1 mi...

    Authors: Ni Liu, Changwen Yang, Xiaohan Liang, Kai Cao, Jun Xie, Qingming Luo and Haiming Luo
    Citation: Journal of Nanobiotechnology 2022 20:439
  26. Clinical diagnostics rely heavily on the detection and quantification of cancer biomarkers. The rapid detection of cancer-specific biomarkers is of great importance in the early diagnosis of cancers and plays ...

    Authors: Hossein Kamali, Shiva Golmohammadzadeh, Hamed Zare, Rahim Nosrati, Mohammad Fereidouni and Hossein Safarpour
    Citation: Journal of Nanobiotechnology 2022 20:438
  27. Photodynamic therapy (PDT), and sonodynamic therapy (SDT) that developed from PDT, have been studied for decades to treat solid tumors. Compared with other deep tumors, the accessibility of urological tumors (...

    Authors: Xiao Hu, Yu-Sen Zhang, Yi-Chao Liu, Na Wang, Xian-Tao Zeng and Ling-Ling Zhang
    Citation: Journal of Nanobiotechnology 2022 20:437
  28. Nanomedicine has emerged as a promising strategy for cancer treatment. The most representative nanomedicine used in clinic is PEGylated liposomal doxorubicin DOXIL®, which is first FDA-approved nanomedicine. Howe...

    Authors: Man Kyu Shim, Suah Yang, Jooho Park, Jun Sik Yoon, Jinseong Kim, Yujeong Moon, Nayeon Shim, Mihee Jo, Yongwhan Choi and Kwangmeyung Kim
    Citation: Journal of Nanobiotechnology 2022 20:436
  29. Exosomes of human cardiosphere-derived cells (CDCs) are very promising for treating cardiovascular disorders. However, the current challenge is inconvenient delivery methods of exosomes for clinical applicatio...

    Authors: Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li and Yan Wang
    Citation: Journal of Nanobiotechnology 2022 20:435
  30. The incidence of myocardial ischaemia‒reperfusion injury (MIRI) is increasing every year, and there is an urgent need to develop new therapeutic approaches. Nrf2 is thought to play a protective role during MIR...

    Authors: Tianyi Wang, Tingting Zhou, Mingming Xu, Shuo Wang, Anqi Wu, Mingyang Zhang, You Lang Zhou and Jiahai Shi
    Citation: Journal of Nanobiotechnology 2022 20:434
  31. Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoin...

    Authors: Linjun Yang, Congcong Yu, Xuhui Fan, Tianni Zeng, Wentao Yang, Jiechao Xia, Jianle Wang, Litao Yao, Chuan Hu, Yang Jin, Yutao Zhu, Jiaxin Chen and Zhijun Hu
    Citation: Journal of Nanobiotechnology 2022 20:433
  32. Effective therapeutics to stop or reverse liver fibrosis have not emerged, because these potential agents cannot specifically target activated hepatic stellate cells (aHSCs) or are frequently toxic to parenchy...

    Authors: Yan Lin, Mengchao Yan, Zhongtian Bai, Ye Xie, Longfei Ren, Jiayun Wei, Dan Zhu, Haiping Wang, Yonggang Liu, Junqian Luo and Xun Li
    Citation: Journal of Nanobiotechnology 2022 20:432
  33. Precision medicine has put forward the proposition of "precision targeting" for modern drug delivery systems. Inspired by techniques from biology, pharmaceutical sciences, and nanoengineering, numerous targete...

    Authors: Haoyue Song, Xiaohang Chen, Yujia Hao, Jia Wang, Qingpeng Xie and Xing Wang
    Citation: Journal of Nanobiotechnology 2022 20:431
  34. The establishment of intestinal in vitro models is crucial for elucidating intestinal cell-microbe intrinsic connections and interaction mechanisms to advance normalized intestinal diagnosis and precision ther...

    Authors: Yanquan Fei, Yong Ma, Huaizu Zhang, Hao Li, Guangfu Feng and Jun Fang
    Citation: Journal of Nanobiotechnology 2022 20:430
  35. Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a c...

    Authors: Lihua Xu, Kaixiang Zhang, Xing Ma, Yingying Li, Yajie Jin, Chenglin Liang, Yong Wang, Wendi Duan, Hongling Zhang, Zhenzhong Zhang, Jinjin Shi, Junjie Liu, Yunlong Wang and Wentao Li
    Citation: Journal of Nanobiotechnology 2022 20:429
  36. Ferroptosis provides an opportunity to overcome the cancer cell therapeutic resistance and modulate the immune system. Here an interaction between ferroptosis of cancer cells and natural killer (NK) cells was ...

    Authors: Kwang-Soo Kim, Bongseo Choi, Hyunjun Choi, Min Jun Ko, Dong-Hwan Kim and Dong-Hyun Kim
    Citation: Journal of Nanobiotechnology 2022 20:428
  37. Primary liver cancer has become the second most fatal cancer in the world, and its five-year survival rate is only 10%. Most patients are in the middle and advanced stages at the time of diagnosis, losing the ...

    Authors: Mengjiao Xu, Liu Yang, Yanjie Lin, Yao Lu, Xiaoyue Bi, Tingting Jiang, Wen Deng, Lu Zhang, Wei Yi, Yao Xie and Minghui Li
    Citation: Journal of Nanobiotechnology 2022 20:427
  38. Skin tissue is vital in protecting the body from injuries and bacterial infections. Wound infection caused by bacterial colonization is one of the main factors hindering wound healing. Wound infection caused b...

    Authors: Yapeng Lu, Meihui Zhao, Ye Peng, Sizhe He, Xiaopeng Zhu, Chao Hu, Guanghua Xia, Tao Zuo, Xueying Zhang, Yonghuan Yun, Weimin Zhang and Xuanri Shen
    Citation: Journal of Nanobiotechnology 2022 20:426
  39. Poor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy in the clinic. The discovery of over-expressed components on the tumor cell surface and their specific ligands prov...

    Authors: Bing Zhang, Ying Zhang, Wenli Dang, Bin Xing, Changxiang Yu, Pan Guo, Jiaxin Pi, Xiuping Deng, Dongli Qi and Zhidong Liu
    Citation: Journal of Nanobiotechnology 2022 20:425
  40. Nanozymes are promising for precise cancer treatment, but are typically limited in terms of the low catalytic efficiency and the complexity in tumor microenvironment (TME). Herein, we describe a bimodal type o...

    Authors: Tao Jia, Dan Li, Jiarui Du, Xikui Fang, Valeriy Gerasimov, Hans Ågren and Guanying Chen
    Citation: Journal of Nanobiotechnology 2022 20:424
  41. Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but...

    Authors: Zekun Shen, Weiyi Wang, Jinxing Chen, Bingyi Chen, Yanan Tang, Jiaxuan Hou, Jiayan Li, Shuang Liu, Yifan Mei, Liwei Zhang and Shaoying Lu
    Citation: Journal of Nanobiotechnology 2022 20:422
  42. Light-mediated nanotherapeutics have recently emerged as promising strategies to precisely control the activation of therapeutic reagents and imaging probe both in vitro and in vivo, largely ascribed to their ...

    Authors: Dan Zhao, Wang Zhang, Shuang Yu, Si-Lei Xia, Ya-Nan Liu and Guan-Jun Yang
    Citation: Journal of Nanobiotechnology 2022 20:421
  43. Intervertebral disc degeneration (IDD) is the pathological reason of back pain and the therapeutic approaches are still unsatisfactory. Recently, mesenchymal stem cell-derived small extracellular vesicles (EVs...

    Authors: Zhiwei Liao, Wencan Ke, Hui Liu, Bide Tong, Kun Wang, Xiaobo Feng, Wenbin Hua, Bingjin Wang, Yu Song, Rongjin Luo, Huaizhen Liang, Weifeng Zhang, Kangcheng Zhao, Shuai Li and Cao Yang
    Citation: Journal of Nanobiotechnology 2022 20:420
  44. Targeting cartilage is a promising strategy for the treatment of osteoarthritis, and various delivery vehicles were developed to assist the therapeutic agents into cartilage. However, the underlying biomechani...

    Authors: Zengxin Jiang, Hao Wang, Zeng Zhang, Jianfeng Pan and Hengfeng Yuan
    Citation: Journal of Nanobiotechnology 2022 20:419
  45. The cell/microenvironment interface is the starting point of integrin-mediated mechanotransduction, but many details of mechanotransductive signal integration remain elusive due to the complexity of the involv...

    Authors: Matteo Chighizola, Tania Dini, Stefania Marcotti, Mirko D’Urso, Claudio Piazzoni, Francesca Borghi, Anita Previdi, Laura Ceriani, Claudia Folliero, Brian Stramer, Cristina Lenardi, Paolo Milani, Alessandro Podestà and Carsten Schulte
    Citation: Journal of Nanobiotechnology 2022 20:418
  46. While improvements in immunoradiotherapy have significantly improved outcomes for cancer patients, this treatment approach has nevertheless proven ineffective at controlling the majority of malignancies. One o...

    Authors: Yun Hu, Sébastien Paris, Genevieve Bertolet, Hampartsoum B. Barsoumian, Kewen He, Duygu Sezen, Dawei Chen, Mark Wasley, Jordan DA SILVA, Joylise A. Mitchell, Tiffany A. Voss, Fatemeh Masrorpour, Claudia Kettlun Leyton, Liangpeng Yang, Carola Leuschner, Nahum Puebla-Osorio…
    Citation: Journal of Nanobiotechnology 2022 20:417
  47. Gastrointestinal cancer (GIC) is a common malignant tumour of the digestive system that seriously threatens human health. Due to the unique organ structure of the gastrointestinal tract, endoscopic and MRI dia...

    Authors: Shenghe Deng, Junnan Gu, Zhenxing Jiang, Yinghao Cao, Fuwei Mao, Yifan Xue, Jun Wang, Kun Dai, Le Qin, Ke Liu, Ke Wu, Qianyuan He and Kailin Cai
    Citation: Journal of Nanobiotechnology 2022 20:415

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