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  1. The therapeutic effect of chemotherapeutics such as gemcitabine against pancreatic cancer is considerably attenuated by immune-suppressive tumor microenvironment. Improvement of chemotherapeutic efficacy by ta...

    Authors: Meng Wang, Qida Hu, Junmin Huang, Xinyu Zhao, Shiyi Shao, Fu Zhang, Zhuo Yao, Yuan Ping and Tingbo Liang
    Citation: Journal of Nanobiotechnology 2022 20:85
  2. Immune checkpoint inhibitor-mediated immunotherapy cannot be carried out on a large scale clinically due to its low universality. In recent years, cyclic guanosine monophosphate synthase/interferon gene stimul...

    Authors: Qian Li, Qiubing Chen, Xue Yang, Yuelan Zhang, Linyue Lv, Zhuyou Zhang, Shaowei Zeng, Jiaxi Lv, Sijin Liu and Bishi Fu
    Citation: Journal of Nanobiotechnology 2022 20:84
  3. No prominent advancements in osteosarcoma (OS) treatment have been made in the past 20 years. Although photodynamic therapy (PDT) is an emerging technique for cancer therapy, the lack of targeted photosensitiz...

    Authors: Yang Wang, Liang Zhang, Guosheng Zhao, Yuan Zhang, Fangbiao Zhan, Zhiyu Chen, Tao He, Yang Cao, Lan Hao, Zhigang Wang, Zhengxue Quan and Yunsheng Ou
    Citation: Journal of Nanobiotechnology 2022 20:83

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:286

  4. Comprehensive antitumor therapy through integrated multimodal means has drawn increasing attention owing to its high efficiency and metastasis suppression.

    Authors: Xiaohong Lin, Tao He, Rui Tang, Qianru Li, Nianhong Wu, Yin Zhou, Hongye He, Li Wan, Ju Huang, Qinqin Jiang, Yixin Zhong, Zhuoyan Xie, Zhongqian Hu, Yang Zhou and Pan Li
    Citation: Journal of Nanobiotechnology 2022 20:80
  5. The malignant transformation of normal resident hepatic stem/progenitor cells has a critical role in hepatocarcinogenesis and the recurrence of hepatocellular carcinoma (HCC). We defined such hepatic progenito...

    Authors: Xiaojuan Hou, Wenting Liu, Xue Yang, Changchun Shao, Lu Gao, Li Zhang and Lixin Wei
    Citation: Journal of Nanobiotechnology 2022 20:79
  6. Despite novel advances in screening, targeting and immunotherapies, early diagnosis and satisfactory treatments against hepatocellular carcinoma (HCC) remain formidable challenges. Given the unique advantages,...

    Authors: Yang Wang, Jun Chen, Jiekang Tian, Guanchen Wang, Weikang Luo, Zebing Huang, Yan Huang, Ning Li, Mingming Guo and Xuegong Fan
    Citation: Journal of Nanobiotechnology 2022 20:78
  7. Supramolecular chirality plays an indispensable role in living and synthetic systems. However, the generation and control of filament chirality in the supramolecular hydrogel of short peptides remains challeng...

    Authors: Xuejiao Yang, Honglei Lu, Yinghua Tao, Hongyue Zhang and Huaimin Wang
    Citation: Journal of Nanobiotechnology 2022 20:77
  8. Dilated cardiomyopathy (DCM) is one of the common causes of heart failure. Myocardial injury triggers an inflammatory response and recruits immune cells into the heart. High expression of Krüppel-like factor 2...

    Authors: Wenfeng Zhang, Ziwei Chen, Shuaihua Qiao, Siyuan Chen, Hongyan Zheng, Xuan Wei, Qiaoling Li, Biao Xu and Wei Huang
    Citation: Journal of Nanobiotechnology 2022 20:76
  9. Atherosclerosis and atherothrombosis, the major contributors to cardiovascular diseases (CVDs), represent the leading cause of death worldwide. Current pharmacological therapies have been associated with side ...

    Authors: Haikun Liu, Geoffrey Pietersz, Karlheinz Peter and Xiaowei Wang
    Citation: Journal of Nanobiotechnology 2022 20:75
  10. Efficacy of targeted drug delivery using nanoparticles relies on several factors including the uptake mechanisms such as phagocytosis, macropinocytosis, micropinocytosis and receptor mediated endocytosis. Thes...

    Authors: Tanmay Kulkarni, Debabrata Mukhopadhyay and Santanu Bhattacharya
    Citation: Journal of Nanobiotechnology 2022 20:74
  11. MicroRNAs have short sequences of 20 ~ 25-nucleotides which are similar among family members and play crucial regulatory roles in numerous biological processes, such as in cell development, metabolism, prolife...

    Authors: Somayeh Mohammadi, Abdollah Salimi, Zohreh Hoseinkhani, Foad Ghasemi and Kamran Mansouri
    Citation: Journal of Nanobiotechnology 2022 20:73
  12. Extracellular vesicles (EVs), released by most cell types, provide an excellent source of biomarkers in biological fluids. However, in order to perform validation studies and screenings of patient samples, it ...

    Authors: Carmen Campos-Silva, Yaiza Cáceres-Martell, Estela Sánchez-Herrero, Amaia Sandúa, Alexandra Beneitez-Martínez, Álvaro González, Mariano Provencio, Atocha Romero, Ricardo Jara-Acevedo, María Yáñez-Mó and Mar Valés‐Gómez
    Citation: Journal of Nanobiotechnology 2022 20:72
  13. Globally, millions of patients are affected by myocardial infarction or lower limb gangrene/amputation due to atherosclerosis. Available surgical treatment based on vein and synthetic grafts provides sub-optim...

    Authors: John Joseph, Vito Domenico Bruno, Nadiah Sulaiman, Alexander Ward, Thomas W. Johnson, Helna Mary Baby, Praveen Kerala Varma, Rajesh Jose, Shantikumar V. Nair, Deepthy Menon, Sarah Jane George and Raimondo Ascione
    Citation: Journal of Nanobiotechnology 2022 20:71

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:173

  14. The infection and spread of porcine reproductive and respiratory syndrome virus (PRRSV) pose a serious threat to the global pig industry, and inhibiting the viral infection process is a promising treatment str...

    Authors: Ting Tong, Shuangfei Deng, Xiaotong Zhang, Liurong Fang, Jiangong Liang and Shaobo Xiao
    Citation: Journal of Nanobiotechnology 2022 20:70
  15. Chemodynamic therapy (CDT) based on Fenton or Fenton-like reactions is an emerging cancer treatment that can both effectively fight cancer and reduce side effects on normal cells and tissues, and it has made i...

    Authors: Yandong Wang, Fucheng Gao, Xiaofeng Li, Guiming Niu, Yufei Yang, Hui Li and Yanyan Jiang
    Citation: Journal of Nanobiotechnology 2022 20:69
  16. Femoral stem of titanium alloy has been widely used for hip arthroplasty with considerable efficacy; however, the application of this implant in patients with osteoporosis is limited due to excessive bone reso...

    Authors: Wei Wang, Yinze Xiong, Renliang Zhao, Xiang Li and Weitao Jia
    Citation: Journal of Nanobiotechnology 2022 20:68
  17. Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein enriched with β-sheet-rich intermediates has been suggested to play a role in the degeneration of neurons and development of...

    Authors: Pallabi Sil Paul, Jae-Young Cho, Qi Wu, Govindarajan Karthivashan, Emily Grabovac, Holger Wille, Marianna Kulka and Satyabrata Kar
    Citation: Journal of Nanobiotechnology 2022 20:67
  18. The engineered nanoformulation that can be activated by intracellular tumor microenvironment, including acidic pH, overexpressed H2O2, and high concentration of glutathione (GSH), features high efficacy to eradic...

    Authors: Shangwen Zhuang, Huijing Xiang, Yixin Chen, Lulu Wang, Yu Chen and Jun Zhang
    Citation: Journal of Nanobiotechnology 2022 20:66
  19. Stem cell-derived exosomes have recently been regarded as potential drugs for treating spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 macrophage polarization. However, th...

    Authors: Chao Liu, Fanqi Hu, Genlong Jiao, Yue Guo, Pan Zhou, Yuning Zhang, Zhen Zhang, Jing Yi, Yonggang You, Zhizhong Li, Hua Wang and Xuesong Zhang
    Citation: Journal of Nanobiotechnology 2022 20:65
  20. While immune checkpoint inhibitors such as anti-PD-L1 antibodies have revolutionized cancer treatment, only subgroups of patients show durable responses. Insight in the relation between clinical response, PD-L...

    Authors: Iris M. Hagemans, Peter J. Wierstra, Kas Steuten, Janneke D. M. Molkenboer-Kuenen, Duco van Dalen, Martin ter Beest, Johan M. S. van der Schoot, Olga Ilina, Martin Gotthardt, Carl G. Figdor, Ferenc A. Scheeren, Sandra Heskamp and Martijn Verdoes
    Citation: Journal of Nanobiotechnology 2022 20:64

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:229

  21. Luminescent nanomaterials (LNMs), especially newly-exploited fluorescent carbon-dots (CDs), have demonstrated promising candidates for sunlight harvesting and enhanced photosynthesis efficiency of crops. Howev...

    Authors: Xin Peng, Zhuomi Xie, Xiuhua Wang, Yuxiang Zhao, Chuyun Yang, Zhongyi Zhang, Mingjie Li, Jianping Zheng and Yuhui Wang
    Citation: Journal of Nanobiotechnology 2022 20:63
  22. Melanoma is the most serious type of skin cancer, and surgery is an effective method to treat melanoma. Unfortunately, local residual micro-infiltrated tumour cells and systemic circulating tumour cells (CTCs)...

    Authors: Jian Zhao, Hao Ye, Qi Lu, Kaiyuan Wang, Xiaofeng Chen, Jiaxuan Song, Helin Wang, Yutong Lu, Maosheng Cheng, Zhonggui He, Yinglei Zhai, Haotian Zhang and Jin Sun
    Citation: Journal of Nanobiotechnology 2022 20:62
  23. Photoimmunotherapy is one of the most promising strategies in tumor immunotherapies, but targeted delivery of photosensitizers and adjuvants to tumors remains a major challenge. Here, as a proof of concept, we...

    Authors: Hu Chen, Pengfei Zhang, Yesi Shi, Chao Liu, Qianqian Zhou, Yun Zeng, Hongwei Cheng, Qixuan Dai, Xing Gao, Xiaoyong Wang and Gang Liu
    Citation: Journal of Nanobiotechnology 2022 20:61
  24. The localization of invisible and impalpable small pulmonary nodules has become an important concern during surgery, since current widely used techniques for localization have a number of limitations, such as ...

    Authors: Haoran Ji, Xiaofeng Wang, Pei Wang, Yan Gong, Yun Wang, Chang Liu, Guangyu Ji, Xiansong Wang and Mingsong Wang
    Citation: Journal of Nanobiotechnology 2022 20:60
  25. Humanization of mouse monoclonal antibodies (mAbs) is crucial for reducing their immunogenicity in humans. However, humanized mAbs often lose their binding affinities. Therefore, an in silico humanization meth...

    Authors: Yuan-Chin Hsieh, Jun-min Liao, Kuo-Hsiang Chuang, Kai-Wen Ho, Shih-Ting Hong, Hui-Ju Liu, Bo-Cheng Huang, I-Ju Chen, Yen-Ling Liu, Jaw-Yuan Wang, Hsiang-Lin Tsai, Yu-Cheng Su, Yen-Tseng Wang and Tian-Lu Cheng
    Citation: Journal of Nanobiotechnology 2022 20:58
  26. Subtalar osteoarthritis (STOA) is often secondary to chronic ankle sprains, which seriously affects the quality of life of patients. Due to its etiology and pathogenesis was not studied equivocally yet, there ...

    Authors: Yu Zhang, Xiaowei Wang, Jian Chen, Dingfei Qian, Peng Gao, Tao Qin, Tao Jiang, Jiang Yi, Tao Xu, Yifan Huang, Qian Wang, Zheng Zhou, Tianyi Bao, Xuan Zhao, Hao Liu, Ziyang Zheng…
    Citation: Journal of Nanobiotechnology 2022 20:56
  27. Methicillin-resistant Staphylococcus aureus (MRSA) biofilm-associated bacterial infection is the primary cause of nosocomial infection and has long been an ongoing threat to public health. MRSA biofilms are often...

    Authors: Yue Zhang, Tianxiang Yue, Wenting Gu, Aidi Liu, Mengying Cheng, Hongyue Zheng, Dandan Bao, Fanzhu Li and Ji-Gang Piao
    Citation: Journal of Nanobiotechnology 2022 20:55
  28. Harnessing the immune system to fight cancer has led to prominent clinical successes. Strategies to stimulate innate immune effectors are attracting considerable interest in cancer therapy. Here, through conju...

    Authors: Xiang-Yu Liu, Mao-Hua Zhu, Xiao-Yu Wang, Xiao Dong, Hai-Jun Liu, Rui-Yang Li, Shi-Chong Jia, Qin Lu, Mei Zhao, Peng Sun, Hong-Zhuan Chen and Chao Fang
    Citation: Journal of Nanobiotechnology 2022 20:54
  29. Sonodynamic therapy (SDT) has emerged as a noninvasive therapeutic modality that involves sonosensitizers and low-intensity ultrasound. However, owing to the rapid recombination of charge carriers, most of the...

    Authors: Dong-Yang Zhang, Hengke Liu, Muhammad Rizwan Younis, Shan Lei, Yunzhi Chen, Peng Huang and Jing Lin
    Citation: Journal of Nanobiotechnology 2022 20:53
  30. Severe acute pancreatitis (SAP) is the most common gastrointestinal disease and is associated with unpredictable seizures and high mortality rates. Despite improvements in the treatment of acute pancreatitis, ...

    Authors: Doudou Lou, Keqing Shi, Hui-Ping Li, Qingfu Zhu, Liang Hu, Jiaxin Luo, Rui Yang and Fei Liu
    Citation: Journal of Nanobiotechnology 2022 20:52
  31. In this study, a thermo-sensitive molecularly imprinted fluorescence sensor was developed for the specific detection of β-Lactoglobulin (β-LG) allergen in milk products. The metal–organic frameworks (MIL-100) ...

    Authors: Liping Hong, Mingfei Pan, Xiao Yang, Xiaoqian Xie, Kaixin Liu, Jingying Yang, Shan Wang and Shuo Wang
    Citation: Journal of Nanobiotechnology 2022 20:51
  32. Although cisplatin-based chemotherapy has been used as the first-line treatment for ovarian cancer (OC), tumor cells develop resistance to cisplatin during treatment, causing poor prognosis in OC patients. Stu...

    Authors: Longxia Li, Di He, Qianqian Guo, Zhiyoung Zhang, Dan Ru, Liting Wang, Ke Gong, Fangfang Liu, Yourong Duan and He Li
    Citation: Journal of Nanobiotechnology 2022 20:50
  33. A widely established prodrug strategy can effectively optimize the unappealing properties of therapeutic agents in cancer treatment. Among them, lipidic prodrugs extremely uplift the physicochemical properties...

    Authors: Lingling Huang, Jianmiao Yang, Tiantian Wang, Jianqing Gao and Donghang Xu
    Citation: Journal of Nanobiotechnology 2022 20:49
  34. Pro-tumoral and immunosuppressive M2-like tumor-associated macrophages (TAMs) contribute to tumor progression, recurrence and distal metastasis. However, current TAMs-modulating therapeutic strategies often en...

    Authors: Yu Liu, Wenting Shang, Heng Liu, Hui Hui, Jun Wu, Wei Zhang, Pengli Gao, Kunxiong Guo, Yanli Guo and Jie Tian
    Citation: Journal of Nanobiotechnology 2022 20:48
  35. Hemostasis and repair are two essential processes in wound healing, yet early hemostasis and following vascularization are challenging to address in an integrated manner.

    Authors: Jie Bian, Luhan Bao, Xiaokang Gao, Xiao Wen, Qiang Zhang, Jinhua Huang, Zhenghui Xiong, Feng F. Hong, Zili Ge and Wenguo Cui
    Citation: Journal of Nanobiotechnology 2022 20:47
  36. Ischemic stroke is the most common cerebrovascular disease and is caused by interruption of blood supply to the brain. To date, recombinant tissue plasminogen activator (rtPA) has been the main pharmacological...

    Authors: Clara Correa-Paz, María F. Navarro Poupard, Ester Polo, Manuel Rodríguez-Pérez, Martina Migliavacca, Ramón Iglesias-Rey, Alberto Ouro, Elena Maqueda, Pablo Hervella, Tomás Sobrino, José Castillo, Pablo del Pino, Beatriz Pelaz and Francisco Campos
    Citation: Journal of Nanobiotechnology 2022 20:46
  37. Inspired by nature, the biomimetic approach has been incorporated into drug nanocarriers for cancer targeted chemotherapy. The nanocarriers are cloaked in cell membranes, which enables them to incorporate the ...

    Authors: Wen Lei, Chen Yang, Yi Wu, Guoqing Ru, Xianglei He, Xiangmin Tong and Shibing Wang
    Citation: Journal of Nanobiotechnology 2022 20:45
  38. The overall survival rate of osteosarcoma (OS) patients has not been improved for 30 years, and the diagnosis and treatment of OS is still a critical issue. To improve OS treatment and prognosis, novel kinds o...

    Authors: Ying Yuan, Shanchao Diao, Xiaoyue Ni, Dong Zhang, Wanrong Yi, Chao Jian, Xiang Hu, Daifeng Li, Aixi Yu, Wen Zhou and Quli Fan
    Citation: Journal of Nanobiotechnology 2022 20:44
  39. Chemodynamic therapy is a promising cancer treatment with specific therapeutic effect at tumor sites, as toxic hydroxyl radical (·OH) could only be generated by Fenton or Fenton-like reaction in the tumor micr...

    Authors: Yingchao Hao, Yue Gao, Yu Fan, Changchang Zhang, Mengsi Zhan, Xueyan Cao, Xiangyang Shi and Rui Guo
    Citation: Journal of Nanobiotechnology 2022 20:43
  40. Despite considerable progress has been achieved in hypoxia-associated anti-tumor therapy, the efficacy of utilizing hypoxia-activated prodrugs alone is not satisfied owing to the inadequate hypoxia within the ...

    Authors: Jie Lv, Shuangling Wang, Duo Qiao, Yulong Lin, Shuyang Hu and Meng Li
    Citation: Journal of Nanobiotechnology 2022 20:42
  41. Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods, soil or water can dramatically improve clinical outcomes and reduce the socioeconomic impact of diseases such as COVID...

    Authors: Julija Dronina, Urte Samukaite-Bubniene and Arunas Ramanavicius
    Citation: Journal of Nanobiotechnology 2022 20:41
  42. The base sequences of DNA are endowed with the rich structural and functional information and are available for the precise construction of the 2D and 3D macro products. The hydrogels formed by DNA are biocomp...

    Authors: Mengmeng Chen, Yu Wang, Jingyang Zhang, Yuan Peng, Shuang Li, Dianpeng Han, Shuyue Ren, Kang Qin, Sen Li and Zhixian Gao
    Citation: Journal of Nanobiotechnology 2022 20:40
  43. Glioblastoma (GBM) is the most common and fatal primary tumor in the central nervous system (CNS). Due to the existence of blood–brain barrier (BBB), most therapeutics cannot efficiently reach tumors in the br...

    Authors: Yong Li, Yixuan Wang, Lun Gao, Yinqiu Tan, Jiayang Cai, Zhang Ye, Ann T. Chen, Yang Xu, Linyao Zhao, Shiao Tong, Qian Sun, Baohui Liu, Shenqi Zhang, Daofeng Tian, Gang Deng, Jiangbing Zhou…
    Citation: Journal of Nanobiotechnology 2022 20:39
  44. Osteoarthritis (OA) is a degenerative illness that greatly impacts the life quality of patients. Currently, the therapeutic approaches for OA are very limited in clinical. The extracellular vesicles (EVs) deri...

    Authors: Kanglu Li, Guohua Yan, Hanji Huang, Mingjun Zheng, Ke Ma, Xiaofei Cui, Dejie Lu, Li Zheng, Bo Zhu, Jianwen Cheng and Jinmin Zhao
    Citation: Journal of Nanobiotechnology 2022 20:38
  45. Gold nanoparticles (AuNPs) are increasingly utilized in industrial and biomedical fields, thereby demanding a more comprehensive knowledge about their safety. Current toxicological studies mainly focus on the ...

    Authors: Yongjun Yang, Shijun Fan, Qian Chen, Yongling Lu, Yuanfeng Zhu, Xiaoli Chen, Lin Xia, Qianying Huang, Jiang Zheng and Xin Liu
    Citation: Journal of Nanobiotechnology 2022 20:37

    The Correction to this article has been published in Journal of Nanobiotechnology 2023 21:239

  46. Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a top killer among infectious diseases. While Bacillus Calmette-Guerin (BCG) is the sole TB vaccine, the clumped-clustered feature...

    Authors: Jiang Pi, Zhiyi Zhang, Enzhuo Yang, Lingming Chen, Lingchan Zeng, Yiwei Chen, Richard Wang, Dan Huang, Shuhao Fan, Wensen Lin, Hongbo Shen, Jun-Fa Xu, Gucheng Zeng and Ling Shen
    Citation: Journal of Nanobiotechnology 2022 20:36
  47. Osteoporosis is a chronic condition affecting patients’ morbidity and mortality and represents a big socioeconomic burden. Because stem cells can proliferate and differentiate into bone-forming cells, stem cel...

    Authors: Chi Zhang, Wei Zhang, Dashuai Zhu, Zhenhua Li, Zhenzhen Wang, Junlang Li, Xuan Mei, Wei Xu, Ke Cheng and Biao Zhong
    Citation: Journal of Nanobiotechnology 2022 20:35
  48. Insufficient radiofrequency ablation (IRFA) can promote the local recurrence and distal metastasis of residual hepatocellular carcinoma (HCC), which makes clinical treatment extremely challenging. In this stud...

    Authors: Xuehua Chen, Yongquan Huang, Hui Chen, Ziman Chen, Jiaxin Chen, Hao Wang, Dan Li and Zhongzhen Su
    Citation: Journal of Nanobiotechnology 2022 20:34

    The Correction to this article has been published in Journal of Nanobiotechnology 2022 20:175

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