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  1. Research

    Uptake of label-free graphene oxide by Caco-2 cells is dependent on the cell differentiation status

    Understanding the interaction of graphene-related materials (GRM) with human cells is a key to the assessment of their potential risks for human health. There is a knowledge gap regarding the potential uptake ...

    Melanie Kucki, Liliane Diener, Nils Bohmer, Cordula Hirsch, Harald F. Krug, Vincenzo Palermo and Peter Wick

    Journal of Nanobiotechnology 2017 15:46

    Published on: 21 June 2017

  2. Research

    The role of intracellular trafficking of CdSe/ZnS QDs on their consequent toxicity profile

    Nanoparticle interactions with cellular membranes and the kinetics of their transport and localization are important determinants of their functionality and their biological consequences. Understanding these p...

    Bella B. Manshian, Thomas F. Martens, Karsten Kantner, Kevin Braeckmans, Stefaan C. De Smedt, Jo Demeester, Gareth J. S. Jenkins, Wolfgang J. Parak, Beatriz Pelaz, Shareen H. Doak, Uwe Himmelreich and Stefaan J. Soenen

    Journal of Nanobiotechnology 2017 15:45

    Published on: 15 June 2017

  3. Research

    Comparative efficacy analysis of anti-microbial peptides, LL-37 and indolicidin upon conjugation with CNT, in human monocytes

    Antimicrobial peptides (AMPs) have the potential to serve as an alternative to antibiotic. AMPs usually exert bactericidal activity via direct killing of microbial pathogens. Reports have proposed that by harn...

    Biswaranjan Pradhan, Dipanjan Guha, Krushna Chandra Murmu, Abhinav Sur, Pratikshya Ray, Debashmita Das and Palok Aich

    Journal of Nanobiotechnology 2017 15:44

    Published on: 12 June 2017

  4. Research

    Nasal delivery of nanoliposome-encapsulated ferric ammonium citrate can increase the iron content of rat brain

    Iron deficiency in children can have significant neurological consequences, and iron supplementation is an effective treatment of choice. However, traditional routes of iron supplementation do not allow effici...

    Xueling Guo, Hong Zheng, Yuetong Guo, Yan Wang, Gregory J. Anderson, Yunzhe Ci, Peng Yu, Lina Geng and Yan-Zhong Chang

    Journal of Nanobiotechnology 2017 15:42

    Published on: 2 June 2017

  5. Research

    Synthesis, characterization, and biological verification of anti-HER2 indocyanine green–doxorubicin-loaded polyethyleneimine-coated perfluorocarbon double nanoemulsions for targeted photochemotherapy of breast cancer cells

    Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death among females worldwide. Among various types of breast cancer, the human epidermal growth factor receptor 2 (HER2)-ov...

    Yu-Hsiang Lee and Yun-Ting Ma

    Journal of Nanobiotechnology 2017 15:41

    Published on: 18 May 2017

  6. Research

    Label-free biosensing of Salmonella enterica serovars at single-cell level

    The emerging nanotechnologies have greatly facilitated the development of label-free biosensors. The atomic force microscopy (AFM) has been used to study the molecular mechanism of the reactions for protein an...

    Bin Wang, Bosoon Park, Bingqian Xu and Yongkuk Kwon

    Journal of Nanobiotechnology 2017 15:40

    Published on: 17 May 2017

  7. Short Communication

    Tracking single baculovirus retrograde transportation in host cell via quantum dot-labeling of virus internal component

    Quantum dot (QD)-based single virus tracking has become a powerful tool for dissecting virus infection mechanism. However, only virus behaviors at the early stage of retrograde trafficking have been dynamicall...

    Li Wen, Zhen-Hua Zheng, An-An Liu, Cheng Lv, Li-Juan Zhang, Jian Ao, Zhi-Ling Zhang, Han-Zhong Wang, Yi Lin and Dai-Wen Pang

    Journal of Nanobiotechnology 2017 15:37

    Published on: 6 May 2017

  8. Research

    A mechanistic investigation exploring the differential transfection efficiencies between the easy-to-transfect SK-BR3 and difficult-to-transfect CT26 cell lines

    Gold–polyamidoamine (AuPAMAM) has previously been shown to successfully transfect cells with high efficiency. However, we have observed that certain cell types are more amenable to Au–PAMAM transfection than o...

    Elizabeth Figueroa, Pallavi Bugga, Vishwaratn Asthana, Allen L. Chen, J. Stephen Yan, Emily Reiser Evans and Rebekah A. Drezek

    Journal of Nanobiotechnology 2017 15:36

    Published on: 2 May 2017

  9. Research

    Highly sensitive and accurate detection of C-reactive protein by CdSe/ZnS quantum dot-based fluorescence-linked immunosorbent assay

    The conventional and widely used enzyme-linked immunosorbent assays (ELISA), due to specificity and high-sensitivity, were suitable in vitro diagnosis. But enzymes are vulnerable to the external conditions, an...

    Yanbing Lv, Ruili Wu, Kunrui Feng, Jinjie Li, Qing Mao, Hang Yuan, Huaibin Shen, Xiangdong Chai and Lin Song Li

    Journal of Nanobiotechnology 2017 15:35

    Published on: 2 May 2017

  10. Research

    A retro-inverso cell-penetrating peptide for siRNA delivery

    Small interfering RNAs (siRNAs) are powerful tools to control gene expression. However, due to their poor cellular permeability and stability, their therapeutic development requires a specific delivery system....

    Anaïs Vaissière, Gudrun Aldrian, Karidia Konate, Mattias F. Lindberg, Carole Jourdan, Anthony Telmar, Quentin Seisel, Frédéric Fernandez, Véronique Viguier, Coralie Genevois, Franck Couillaud, Prisca Boisguerin and Sébastien Deshayes

    Journal of Nanobiotechnology 2017 15:34

    Published on: 28 April 2017

  11. Review

    Nanoparticles based on essential metals and their phytotoxicity

    Nanomaterials in agriculture are becoming popular due to the impressive advantages of these particles. However, their bioavailability and toxicity are key features for their massive employment. Herein, we comp...

    Branislav Ruttkay-Nedecky, Olga Krystofova, Lukas Nejdl and Vojtech Adam

    Journal of Nanobiotechnology 2017 15:33

    Published on: 26 April 2017

  12. Research

    Aggregation/dispersion transitions of T4 phage triggered by environmental ion availability

    Bacteriophage survives in at least two extremes of ionic environments: bacterial host (high ionic-cytosol) and that of soil (low ionic-environmental water). The impact of ionic composition in the micro- and macro...

    Bożena Szermer-Olearnik, Marek Drab, Mateusz Mąkosa, Maria Zembala, Jakub Barbasz, Krystyna Dąbrowska and Janusz Boratyński

    Journal of Nanobiotechnology 2017 15:32

    Published on: 24 April 2017

  13. Research

    Chitosan nanoparticle-mediated co-delivery of shAtg-5 and gefitinib synergistically promoted the efficacy of chemotherapeutics through the modulation of autophagy

    Autophagy reportedly plays vital and complex roles in many diseases. During times of starvation or energy deficiency, autophagy will occur at higher levels to provide cells with the nutrients or energy necessa...

    Yan Zheng, Chang Su, Liang Zhao and Yijie Shi

    Journal of Nanobiotechnology 2017 15:28

    Published on: 11 April 2017

  14. Review

    Vectorized nanodelivery systems for ischemic stroke: a concept and a need

    Neurological diseases of diverse aetiologies have significant effects on the quality of life of patients. The limited self-repairing capacity of the brain is considered to be the origin of the irreversible and...

    Andrés Da Silva-Candal, Bárbara Argibay, Ramón Iglesias-Rey, Zulema Vargas, Alba Vieites-Prado, Esteban López-Arias, Emilio Rodríguez-Castro, Iria López-Dequidt, Manuel Rodríguez-Yáñez, Yolanda Piñeiro, Tomás Sobrino, Francisco Campos, José Rivas and José Castillo

    Journal of Nanobiotechnology 2017 15:30

    Published on: 11 April 2017

  15. Research

    Biodistribution of arctigenin-loaded nanoparticles designed for multimodal imaging

    Tracking targets of natural products is one of the most challenging issues in fields ranging from pharmacognosy to biomedicine. It is widely recognized that the biocompatible nanoparticle (NP) could function a...

    Qingxin Cui, Yuanyuan Hou, Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao, Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng and Gang Bai

    Journal of Nanobiotechnology 2017 15:27

    Published on: 7 April 2017

  16. Research

    Multi-walled carbon nanotubes functionalized with recombinant Dengue virus 3 envelope proteins induce significant and specific immune responses in mice

    Dengue is the most prevalent arthropod-borne viral disease in the world. In this article we present results on the development, characterization and immunogenic evaluation of an alternative vaccine candidate a...

    Alice F. Versiani, Ruiz G. Astigarraga, Eliseu S. O. Rocha, Ana Paula M. Barboza, Erna G. Kroon, Milene A. Rachid, Daniele G. Souza, Luiz O. Ladeira, Edel F. Barbosa-Stancioli, Ado Jorio and Flávio G. Da Fonseca

    Journal of Nanobiotechnology 2017 15:26

    Published on: 4 April 2017

  17. Review

    Development of nanoparticle-based optical sensors for pathogenic bacterial detection

    Pathogenic bacteria contribute to various globally important diseases, killing millions of people each year. Various fields of medicine currently benefit from or may potentially benefit from the use of nanotec...

    Teodora Mocan, Cristian T. Matea, Teodora Pop, Ofelia Mosteanu, Anca Dana Buzoianu, Cosmin Puia, Cornel Iancu and Lucian Mocan

    Journal of Nanobiotechnology 2017 15:25

    Published on: 31 March 2017

  18. Research

    Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs

    Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we in...

    Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel

    Journal of Nanobiotechnology 2017 15:24

    Published on: 29 March 2017

  19. Methodology

    Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

    The adhesion of cells to an oscillating cantilever sensitively influences the oscillation amplitude at a given frequency. Even early stages of cytotoxicity cause a change in the viscosity of the cell membrane ...

    Fang Yang, René Riedel, Pablo del Pino, Beatriz Pelaz, Alaa Hassan Said, Mahmoud Soliman, Shashank R. Pinnapireddy, Neus Feliu, Wolfgang J. Parak, Udo Bakowsky and Norbert Hampp

    Journal of Nanobiotechnology 2017 15:23

    Published on: 22 March 2017

  20. Research

    Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry

    We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versa...

    André G. Próspero, Caio C. Quini, Andris F. Bakuzis, Patrícia Fidelis-de-Oliveira, Gustavo M. Moretto, Fábio P. F. Mello, Marcos F. F. Calabresi, Ronaldo V. R. Matos, Ednaldo A. Zandoná, Nícholas Zufelato, Ricardo B. Oliveira and José R. A. Miranda

    Journal of Nanobiotechnology 2017 15:22

    Published on: 21 March 2017

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