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  1. Methodology

    Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope

    The adhesion of cells to an oscillating cantilever sensitively influences the oscillation amplitude at a given frequency. Even early stages of cytotoxicity cause a change in the viscosity of the cell membrane ...

    Fang Yang, René Riedel, Pablo del Pino, Beatriz Pelaz, Alaa Hassan Said, Mahmoud Soliman, Shashank R. Pinnapireddy, Neus Feliu, Wolfgang J. Parak, Udo Bakowsky and Norbert Hampp

    Journal of Nanobiotechnology 2017 15:23

    Published on: 22 March 2017

  2. Research

    Real-time in vivo monitoring of magnetic nanoparticles in the bloodstream by AC biosusceptometry

    We introduce and demonstrate that the AC biosusceptometry (ACB) technique enables real-time monitoring of magnetic nanoparticles (MNPs) in the bloodstream. We present an ACB system as a simple, portable, versa...

    André G. Próspero, Caio C. Quini, Andris F. Bakuzis, Patrícia Fidelis-de-Oliveira, Gustavo M. Moretto, Fábio P. F. Mello, Marcos F. F. Calabresi, Ronaldo V. R. Matos, Ednaldo A. Zandoná, Nícholas Zufelato, Ricardo B. Oliveira and José R. A. Miranda

    Journal of Nanobiotechnology 2017 15:22

    Published on: 21 March 2017

  3. Research

    Quantification of silver nanoparticle uptake and distribution within individual human macrophages by FIB/SEM slice and view

    Quantification of nanoparticle (NP) uptake in cells or tissues is very important for safety assessment. Often, electron microscopy based approaches are used for this purpose, which allow imaging at very high r...

    Erik Guehrs, Michael Schneider, Christian M. Günther, Piet Hessing, Karen Heitz, Doreen Wittke, Ana López-Serrano Oliver, Norbert Jakubowski, Johanna Plendl, Stefan Eisebitt and Andrea Haase

    Journal of Nanobiotechnology 2017 15:21

    Published on: 21 March 2017

  4. Research

    Selenium nanoparticles decorated with Ulva lactuca polysaccharide potentially attenuate colitis by inhibiting NF-κB mediated hyper inflammation

    Selenium (Se) is an essential micronutrient trace element and an established nutritional antioxidant. Low Se status exacerbates inflammatory bowel diseases progression, which involves hyper inflammation in the...

    Chenghui Zhu, Shuimei Zhang, Chengwei Song, Yibo Zhang, Qinjie Ling, Peter R. Hoffmann, Jun Li, Tianfeng Chen, Wenjie Zheng and Zhi Huang

    Journal of Nanobiotechnology 2017 15:20

    Published on: 7 March 2017

  5. Review

    Non-invasive continuous monitoring of pro-oxidant effects of engineered nanoparticles on aquatic microorganisms

    Engineered nanomaterials (ENMs) are key drivers for the development of highly sophisticated new technologies. As all new attainments, the rapidly increasing used of ENMs raise concerns about their safety for t...

    Christian Santschi, Nadia Von Moos, Volodymyr B. Koman, Vera I. Slaveykova, Paul Bowen and Olivier J. F. Martin

    Journal of Nanobiotechnology 2017 15:19

    Published on: 7 March 2017

  6. Research

    Understanding cellular internalization pathways of silicon nanowires

    Understanding how cells interact with nanomaterials is important for rational design of nanomaterials for nanomedicine and transforming them for clinical applications. Particularly, the mechanism for one-dimen...

    Kelly McNear, Yimin Huang and Chen Yang

    Journal of Nanobiotechnology 2017 15:17

    Published on: 1 March 2017

  7. Research

    Enhancement of scutellarin oral delivery efficacy by vitamin B12-modified amphiphilic chitosan derivatives to treat type II diabetes induced-retinopathy

    Diabetic retinopathy is the most common complication in diabetic patients relates to high expression of VEGF and microaneurysms. Scutellarin (Scu) turned out to be effective against diabetes related vascular e...

    Jingnan Wang, Jiayun Tan, Jiahao Luo, Peilin Huang, Wuyi Zhou, Luming Chen, Lingli Long, Li-ming Zhang, Banghao Zhu, Liqun Yang and David Y. B. Deng

    Journal of Nanobiotechnology 2017 15:18

    Published on: 1 March 2017

  8. Review

    Transformation of the released asbestos, carbon fibers and carbon nanotubes from composite materials and the changes of their potential health impacts

    Composite materials with fibrous reinforcement often provide superior mechanical, thermal, electrical and optical properties than the matrix. Asbestos, carbon fibers and carbon nanotubes (CNTs) have been widel...

    Jing Wang, Lukas Schlagenhauf and Ari Setyan

    Journal of Nanobiotechnology 2017 15:15

    Published on: 20 February 2017

  9. Research

    Impact of semi-solid formulations on skin penetration of iron oxide nanoparticles

    This work aimed to provide useful information on the incidence of the choice of formulation in semi-solid preparations of iron-oxide nanoparticles (IONs). The appropriate analytical methods to assess the IONs ...

    Umberto M. Musazzi, Benedetta Santini, Francesca Selmin, Valentina Marini, Fabio Corsi, Raffaele Allevi, Anna M. Ferretti, Davide Prosperi, Francesco Cilurzo, Miriam Colombo and Paola Minghetti

    Journal of Nanobiotechnology 2017 15:14

    Published on: 17 February 2017

  10. Research

    Anthocyanins encapsulated by PLGA@PEG nanoparticles potentially improved its free radical scavenging capabilities via p38/JNK pathway against Aβ1–42-induced oxidative stress

    In order to increase the bioavailability of hydrophilic unstable drugs like anthocyanins, we employed a polymer-based nanoparticles approach due to its unique properties such as high stability, improved bioava...

    Faiz Ul Amin, Shahid Ali Shah, Haroon Badshah, Mehtab Khan and Myeong Ok Kim

    Journal of Nanobiotechnology 2017 15:12

    Published on: 7 February 2017

  11. Research

    Poly-lactic acid nanoparticles (PLA-NP) promote physiological modifications in lung epithelial cells and are internalized by clathrin-coated pits and lipid rafts

    Poly-lactic acid nanoparticles (PLA-NP) are a type of polymeric NP, frequently used as nanomedicines, which have advantages over metallic NP such as the ability to maintain therapeutic drug levels for sustaine...

    Camila Macedo da Luz, Matthew Samuel Powys Boyles, Priscila Falagan-Lotsch, Mariana Rodrigues Pereira, Henrique Rudolf Tutumi, Eidy de Oliveira Santos, Nathalia Balthazar Martins, Martin Himly, Aniela Sommer, Ilse Foissner, Albert Duschl, José Mauro Granjeiro and Paulo Emílio Corrêa Leite

    Journal of Nanobiotechnology 2017 15:11

    Published on: 31 January 2017

  12. Research

    Improved in vitro angiogenic behavior on anodized titanium dioxide nanotubes

    Neovascularization over dental implants is an imperative requisite to achieve successful osseointegration onto implanted materials. The aim of this study was to investigate the effects on in vitro angiogenesis...

    Ernesto Beltrán-Partida, Benjamín Valdéz-Salas, Aldo Moreno-Ulloa, Alan Escamilla, Mario A. Curiel, Raúl Rosales-Ibáñez, Francisco Villarreal, David M. Bastidas and José M. Bastidas

    Journal of Nanobiotechnology 2017 15:10

    Published on: 31 January 2017

  13. Research

    Targeted imaging and induction of apoptosis of drug-resistant hepatoma cells by miR-122-loaded graphene-InP nanocompounds

    Currently, graphene oxide has attracted growing attention as a drug delivery system due to its unique characteristics. Furthermore, utilization of microRNAs as biomarkers and therapeutic strategies would be pa...

    Xin Zeng, Yi Yuan, Ting Wang, Han Wang, Xianyun Hu, Ziyi Fu, Gen Zhang, Bin Liu and Guangming Lu

    Journal of Nanobiotechnology 2017 15:9

    Published on: 23 January 2017

  14. Research

    C60 fullerene as promising therapeutic agent for correcting and preventing skeletal muscle fatigue

    Bioactive soluble carbon nanostructures, such as the C60 fullerene can bond with up to six electrons, thus serving by a powerful scavenger of reactive oxygen species similarly to many natural antioxidants, widely...

    Yurij I. Prylutskyy, Inna V. Vereshchaka, Andriy V. Maznychenko, Nataliya V. Bulgakova, Olga O. Gonchar, Olena A. Kyzyma, Uwe Ritter, Peter Scharff, Tomasz Tomiak, Dmytro M. Nozdrenko, Iryna V. Mishchenko and Alexander I. Kostyukov

    Journal of Nanobiotechnology 2017 15:8

    Published on: 13 January 2017

  15. Research

    Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

    A targeted drug nanoparticle (NP) delivery system has shown potential as a possible cancer treatment. Given its merits, such as its selective distribution at tumor sites and its controllable drug release, drug...

    Tao Wang, Jiahui Hou, Chang Su, Liang Zhao and Yijie Shi

    Journal of Nanobiotechnology 2017 15:7

    Published on: 10 January 2017

  16. Review

    Interaction of biomedical nanoparticles with the pulmonary immune system

    Engineered nanoparticles (NPs) offer site-specific delivery, deposition and cellular uptake due to their unique physicochemical properties and were shown to modulate immune responses. The respiratory tract wit...

    Fabian Blank, Kleanthis Fytianos, Emilie Seydoux, Laura Rodriguez-Lorenzo, Alke Petri-Fink, Christophe von Garnier and Barbara Rothen-Rutishauser

    Journal of Nanobiotechnology 2017 15:6

    Published on: 9 January 2017

  17. Research

    Cytotoxic effects of nanosilver are highly dependent on the chloride concentration and the presence of organic compounds in the cell culture media

    Nanosilver shows great promise for use in industrial, consumer or medical products because of its antimicrobial properties. However, the underlying mechanisms of the effects of silver nanoparticles on human ce...

    Jean-Pierre Kaiser, Matthias Roesslein, Liliane Diener, Adrian Wichser, Bernd Nowack and Peter Wick

    Journal of Nanobiotechnology 2017 15:5

    Published on: 6 January 2017

  18. Research

    Antioxidant capacities of the selenium nanoparticles stabilized by chitosan

    Selenium (Se) as one of the essential trace elements for human plays an important role in the oxidation reduction system. But the high toxicity of Se limits its application. In this case, the element Se with z...

    Xiaona Zhai, Chunyue Zhang, Guanghua Zhao, Serge Stoll, Fazheng Ren and Xiaojing Leng

    Journal of Nanobiotechnology 2017 15:4

    Published on: 5 January 2017

  19. Research

    Elasto-inertial microfluidics for bacteria separation from whole blood for sepsis diagnostics

    Bloodstream infections (BSI) remain a major challenge with high mortality rate, with an incidence that is increasing worldwide. Early treatment with appropriate therapy can reduce BSI-related morbidity and mor...

    Muhammad Asim Faridi, Harisha Ramachandraiah, Indradumna Banerjee, Sahar Ardabili, Sergey Zelenin and Aman Russom

    Journal of Nanobiotechnology 2017 15:3

    Published on: 4 January 2017

  20. Research

    Pterodon emarginatus oleoresin-based nanoemulsion as a promising tool for Culex quinquefasciatus (Diptera: Culicidae) control

    Preparation of nanoformulations using natural products as bioactive substances is considered very promising for innovative larvicidal agents. On this context, oil in water nanoemulsions develop a main role, si...

    Anna E. M. F. M. Oliveira, Jonatas L. Duarte, Rodrigo A. S. Cruz, Raimundo N. P. Souto, Ricardo M. A. Ferreira, Taires Peniche, Edemilson C. da Conceição, Leandra A. R. de Oliveira, Silvia M. M. Faustino, Alexandro C. Florentino, José C. T. Carvalho and Caio P. Fernandes

    Journal of Nanobiotechnology 2017 15:2

    Published on: 3 January 2017

  21. Research

    Intracellular trafficking and cellular uptake mechanism of PHBV nanoparticles for targeted delivery in epithelial cell lines

    Nanotechnology is a science that involves imaging, measurement, modeling and a manipulation of matter at the nanometric scale. One application of this technology is drug delivery systems based on nanoparticles...

    Juan P. Peñaloza, Valeria Márquez-Miranda, Mauricio Cabaña-Brunod, Rodrigo Reyes-Ramírez, Felipe M. Llancalahuen, Cristian Vilos, Fernanda Maldonado-Biermann, Luis A. Velásquez, Juan A. Fuentes, Fernando D. González-Nilo, Maité Rodríguez-Díaz and Carolina Otero

    Journal of Nanobiotechnology 2017 15:1

    Published on: 3 January 2017

  22. Research

    Synthesis and functionalization of protease-activated nanoparticles with tissue plasminogen activator peptides as targeting moiety and diagnostic tool for pancreatic cancer

    Functionalized nanoparticles (NPs) are one promising tool for detecting specific molecular targets and combine molecular biology and nanotechnology aiming at modern imaging. We aimed at ligand-directed deliver...

    Sophie Dobiasch, Szilard Szanyi, Aleko Kjaev, Jens Werner, Albert Strauss, Christian Weis, Lars Grenacher, Katya Kapilov-Buchman, Liron-Limor Israel, Jean-Paul Lellouche, Erica Locatelli, Mauro Comes Franchini, Jennifer Vandooren, Ghislain Opdenakker and Klaus Felix

    Journal of Nanobiotechnology 2016 14:81

    Published on: 19 December 2016

  23. Research

    Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging

    Multifunctional nanocarriers for controlled drug delivery, imaging of disease development and follow-up of treatment efficacy are promising novel tools for disease diagnosis and treatment. In the current inves...

    Heba Asem, Ying Zhao, Fei Ye, Åsa Barrefelt, Manuchehr Abedi-Valugerdi, Ramy El-Sayed, Ibrahim El-Serafi, Khalid M. Abu-Salah, Jörg Hamm, Mamoun Muhammed and Moustapha Hassan

    Journal of Nanobiotechnology 2016 14:82

    Published on: 19 December 2016

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